ACONTECE NA ABIFINA

Estudos sobre vacinas, drogas em desenvolvimento, drogas tradicionais, protocolos clínicos e suprimentos de IFAs para tratamento da Covid-19 (16/08/2022)

Acompanhe as atualizações! 

 

Clinical Practice Guidelines From the Association for the Advancement of Blood and Biotherapies (AABB): COVID-19 Convalescent Plasma

16 August 2022 - Coronavirus disease 2019 convalescent plasma (CCP) has emerged as a potential treatment of COVID-19. However, meta-analysis data and recommendations are limited. The Association for the Advancement of Blood and Biotherapies (AABB) developed clinical practice guidelines for the appropriate use of CCP

 

Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach

12 August 2022 - Tocilizumab and Sarilumab are promising in COVID-19 cytokine storm management

 

Mesenchymal stem cells and their derived small extracellular vesicles for COVID-19 treatment

12 August 2022 - The preclinical studies and clinical trials using MSCs and small extracellular vesicles derived from MSCs (MSC-sEVs) in treating COVID-19 were summarized. Then, the molecular mechanism, feasibility, and safety of treating COVID-19 with MSCs and MSC-sEVs were also discussed

 

PIKfyve-specific inhibitors restrict replication of multiple coronaviruses in vitro but not in a murine model of COVID-19

12 August 2022 - Here we show that, while Apilimod and other PIKfyve inhibitors have potent antiviral activity in various cell lines against multiple human coronaviruses, these compounds worsen disease in a COVID-19 murine model when given prophylactically or therapeutically.

 

Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV-2

12 August 2022 - In summary, our structure-based computational and biochemical approach identified novel naphthoquinonal scaffolds that can be further explored as SARS-CoV-2 antivirals.

 

Evaluation of safety and immunogenicity of receptor-binding domain-based COVID-19 vaccine (Corbevax) to select the optimum formulation in open-label, multicentre, and randomised phase-1/2 and phase-2 clinical trials

12 August 2022 - We assessed the efficacy of a receptor-binding domain (RBD)-based protein subunit COVID-19 vaccine

 

Effectiveness of BNT162b2 Vaccine against Omicron in Children 5 to 11 Years of Age

11 August 2022 - During a period when the omicron variant was predominant, BNT162b2 vaccination reduced the risks of SARS-CoV-2 infection and Covid-19–related hospitalization among children 5 to 11 years of age

 

Safety of COVID-19 vaccines in pregnancy: a Canadian National Vaccine Safety (CANVAS) network cohort study

11 August 2022 - his study aimed to determine the frequency and nature of significant health events among pregnant females after COVID-19 vaccination, compared with unvaccinated pregnant controls and vaccinated non-pregnant individuals

 

Immunogenicity of ChAdOx1-nCoV-19 vaccine in solid malignancy patients by treatment regimen versus healthy controls: A prospective, multicenter observational study

10 August 2022 - We aimed to assess the immunogenicity of the ChAdOx1-nCoV-19 vaccine and the impact of different anticancer therapies for solid malignancies on immune response

 

Safety and immunogenicity following a homologous booster dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): a secondary analysis of a randomised, placebo-controlled, phase 2 trial

10 August 2022 - Booster doses of SARS-CoV-2 vaccines might address these concerns by amplifying and broadening the immune responses seen with initial vaccination regimens. We aimed to assess the immunogenicity and safety of a homologous booster dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373)

 

Coronavirus disease 2019 convalescent plasma (CCP) has emerged as a potential treatment of COVID-19. However, meta-analysis data and recommendations are limited. The Association for the Advancement of Blood and Biotherapies (AABB) developed clinical practice guidelines for the appropriate use of CCP

09 August 2022 - The anti-inflammatory activities of schaftoside were confirmed on lipopolysaccharide-induced acute lung injury mice. Schaftoside showed good safety and pharmacokinetic property, and could be a promising drug candidate for the prevention and treatment of COVID-19

 

A Multiscale Model of COVID-19 Dynamics

09 August 2022 - Our work underlines the potential role that the environment can play in the transmission of COVID-19. Antiviral treatment of infected individuals can delay but cannot prevent the emergence of disease outbreaks

 

Selective serotonin reuptake inhibitor (SSRI) antidepressants reduce COVID-19 infection: prospects for use

09 August 2022 - If successful, these drugs can substantially reduce hospitalization and mortality rates, as well as allow for fully outpatient treatment for mild-to-moderate infections

 

Seasonal variation of the composition of essential oils from Piper cernuum Vell and Piper rivinoides Kunth, ADMET study, DFT calculations, molecular docking and dynamics studies of major components as potent inhibitors of the heterodimer methyltransferase complex NSP16-NSP10 SARS COV-2 protein

09 August 2022 - Molecular docking and molecular dynamics studies represent an initial step, being indicative for future in vitro studies of dihydroagarofuran and myristicin, as possible pharmacological tools for COVID-19

 

The mechanism of RNA capping by SARS-CoV-2

09 August 2022 - Collectively, our results reveal an unconventional mechanism by which SARS-CoV-2 caps its RNA genome, thus exposing a new target in the development of antivirals to treat COVID-19

 

Vaccine effectiveness of two-dose BNT162b2 against symptomatic and severe COVID-19 among adolescents in Brazil and Scotland over time: a test-negative case-control study

08 August 2022 - We found waning vaccine protection of BNT162b2 against symptomatic COVID-19 infection among adolescents in Brazil and Scotland from 27 days after the second dose. However, protection against severe COVID-19 outcomes remained high at 98 days or more after the second dose in the omicron-dominant period. Booster doses for adolescents need to be considered

 

Direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer

04 August 2022 - This methodology demonstrated superior performance in assessing NAb titer compared to either measurement of total anti-spike immunoglobulin G titer or quantification of the absolute reduction in binding between ACE2 and RBD

 

Multivalent ACE2 engineering-a promising pathway for advanced coronavirus nanomedicine development

04 August 2022 - Beyond coronaviruses, these approaches will serve as a paradigm to develop new and improved treatment technologies against pathogens that use ACE2 receptor for invasion

 

Scope of repurposed drugs against the potential targets of the latest variants of SARS-CoV-2

03 August 2022 - The interaction modelling of some important repurposed drugs has also been elucidated. Furthermore, the merits and demerits of drug repurposing are also discussed, with a focus on the scope and applications of the latest advancements in repurposing

 

Allosteric Binding Sites of the SARS-CoV-2 Main Protease: Potential Targets for Broad-Spectrum Anti-Coronavirus Agents

02 August 2022 - This review paper gives a detailed insight into the feasibility of developing new Mpro inhibitors to act as a potential treatment for the COVID-19 disease

 

Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron

29 July 2022 - These findings suggest an epitope-targeting strategy to identify potent and broadly neutralizing antibodies for design of pan-sarbecovirus vaccines and antibody therapeutics

 

Omicron SARS-CoV-2 epidemic in England during February 2022: A series of cross-sectional community surveys

28 July 2022 - The Omicron wave of COVID-19 in England peaked in January 2022 resulting from the rapid transmission of the Omicron BA.1 variant. We investigate the spread and dynamics of the SARS-CoV-2 epidemic in the population of England during February 2022, by region, age and main SARS-CoV-2 sub-lineage

 

A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions

27 July 2022 - We report a live-attenuated SARS-CoV-2 vaccine candidate with (i) re-engineered viral transcription regulator sequences and (ii) deleted open-reading-frames (ORF) 3, 6, 7, and 8 (∆3678)

 

Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

27 July 2022 - Although the Omicron variant (BA.1, BA.1.1, and BA.2) shows the most escape from neutralization, sera collected after a third dose of vaccine (booster sera) retain moderate neutralizing activity against that variant. Therefore, vaccination remains an effective strategy during the COVID-19 pandemic

 

Safety and immunogenicity of a SARS-CoV-2 recombinant protein nanoparticle vaccine (GBP510) adjuvanted with AS03: A randomised, placebo-controlled, observer-blinded phase 1/2 trial

22 July 2022 - Vaccination has helped to mitigate the COVID-19 pandemic. Ten traditional and novel vaccines have been listed by the World Health Organization for emergency use. Additional alternative approaches may better address ongoing vaccination globally, where there remains an inequity in vaccine distribution

 

Neutralising antibody responses to SARS-CoV-2 omicron among elderly nursing home residents following a booster dose of BNT162b2 vaccine: A community-based, prospective, longitudinal cohort study

22 July 2022 - The protective immunity against omicron following a BNT162b2 Pfizer booster dose among elderly individuals (ie, those aged >65 years) is not well characterised

 

BNT162b2 Vaccine Effectiveness against Omicron in Children 5 to 11 Years of Age

21 July 2022 - The cumulative incidence of each outcome in the two study groups through January 7, 2022, was estimated with the use of the Kaplan–Meier estimator, and vaccine effectiveness was calculated as 1 minus the risk ratio. Vaccine effectiveness was also estimated in age subgroups

 

Effectiveness of BNT162b2 Vaccine against Omicron in Children 5 to 11 Years of Age

20 July 2022 - Since it was first identified in early November 2021, the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread quickly and replaced the B.1.617.2 (delta) variant as the dominant variant in many countries. Data on the real-world effectiveness of vaccines against the omicron variant in children are lacking

 

Effectiveness of BBIBP-CorV, BNT162b2 and mRNA-1273 vaccines against hospitalisations among children and adolescents during the Omicron outbreak in Argentina: A retrospective cohort study

16 July 2022 - Many countries started the vaccination rollout of children in 2021; still, information about effectiveness in the real-world setting is scarce. The aim of our study was to evaluate vaccine effectiveness (VE) against COVID-19-associated-hospitalisations in the 3–17-year population during the Omicron outbreak

 

Post-recovery COVID-19 and incident heart failure in the National COVID Cohort Collaborative (N3C) study

15 July 2022 -In conclusion, COVID-19 hospitalization is associated with increased risk of incident heart failure

 

SARS-CoV-2 accelerated clearance using a novel nitric oxide nasal spray (NONS) treatment: A randomized trial

12 July 2022 - Additional outpatient therapies which are readily accessible will be essential to reduce COVID-19 illness progression in high risk individuals. Especially as the virus continues to mutate with greater transmissibility despite increased global vaccination

 

Limited neutralisation of the SARS-CoV-2 Omicron subvariants BA.1 and BA.2 by convalescent and vaccine serum and monoclonal antibodies

11 July 2022 - In recent months, Omicron variants of SARS-CoV-2 have become dominant in many regions of the world, and case numbers with Omicron subvariants BA.1 and BA.2 continue to increase. Due to numerous mutations in the spike protein, the efficacy of currently available vaccines, which are based on Wuhan-Hu 1 isolate of SARS-CoV-2, is reduced, leading to breakthrough infections. Efficacy of monoclonal antibody therapy is also likely impaired

 

Safety and efficacy of mesenchymal stem cells in severe/critical patients with COVID-19: A systematic review and meta-analysis

09 July 2022 - The present study aims to better understand the efficacy and safety of mesenchymal stromal cells (MSCs) in treating severe/critical patients with COVID-19

 

Robust long-term immunity to SARS-CoV-2 in patients recovered from severe COVID-19 after interleukin-6 blockade

08 July 2022 - Whether interleukin-6 (IL-6) blockade in patients with COVID-19 will affect the protective immunity against SARS-CoV-2 has become an important concern for anti-IL-6 therapy. We aimed to investigate the effects of IL-6 blockade on long-term immunity to SARS-CoV-2

 

Effects of Previous Infection and Vaccination on Symptomatic Omicron Infections

07 July 2022 - Previous infection alone, BNT162b2 vaccination alone, and hybrid immunity all showed strong effectiveness (>70%) against severe, critical, or fatal Covid-19 due to BA.2 infection. Similar results were observed in analyses of effectiveness against BA.1 infection and of vaccination with mRNA-1273

 

Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

04 July 2022 - In hamsters, two doses of the vaccine attenuated severe pneumonia and reduced inflammatory infiltrates after a challenge with live SARS-CoV-2. Inhalable and room-temperature-stable virus-like particles may become promising vaccine candidates

 

SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection

29 June 2022 - Single-dose vaccination targeted to those previously infected may provide at least as good protection to two-dose vaccination among those without previous infection

 

Rapid evaluation of COVID-19 vaccine effectiveness against symptomatic infection with SARS-CoV-2 variants by analysis of genetic distance

16 June 2022 - Among the four sublineages of Omicron, the predicted VE varied between 11.9% and 33.3%, with the highest VE predicted against BA.1 and the lowest against BA.2, using the mRNA vaccine platform. The VE-GD framework enables predictions of vaccine protection in real time and offers a rapid evaluation method against novel variants that may inform vaccine deployment and public health responses

 

Expansion of cytotoxic tissue-resident CD8+ T cells and CCR6+CD161+ CD4+ T cells in the nasal mucosa following mRNA COVID-19 vaccination

10 June 2022 - Stimulation of nasal CD8+ T cells with SARS-CoV-2 spike peptides elevates expression of CD107a at 2- and 6-months (p = 0.0096) post second vaccine dose, with a subset of donors also expressing increased cytokines. These data suggest that nasal T cells may be induced and contribute to the protective immunity afforded by this vaccine

 

Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19

09 June 2022 - A single dose of AZD7442 had efficacy for the prevention of Covid-19, without evident safety concerns

 

Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2

09 June 2022 - Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provides natural immunity against reinfection. Recent studies have shown waning of the immunity provided by the BNT162b2 vaccine. The time course of natural and hybrid immunity is unknown

 

Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infection

07 June 2022 - The SAM vaccine is currently being evaluated in clinical trials as both a homologous prime-boost regimen at low doses and as a boost following heterologous prime

 

Efficacy and Safety of the RBD-Dimer–Based Covid-19 Vaccine ZF2001 in Adults

02 June 2022 - In a large cohort of adults, the ZF2001 vaccine was shown to be safe and effective against symptomatic and severe-to-critical Covid-19 for at least 6 months after full vaccination

 

Alterations of blood monocyte subset distribution and surface phenotype are linked to infection severity in COVID-19 inpatients

02 May 2022 - These alterations of the myeloid leukocyte compartment during acute COVID-19 may be hallmarks of inefficient viral control and immune hyper-activation and may and help at risk prediction and treatment optimization

 

How effective is rescue therapeutic plasma exchange in treatment of SARS-Coronavirus-2?

01 May 2022 - SARS-CoV-2 patients who failed all other therapies had significant mortality with therapeutic plasma exchange; however, their survival was better than SARS-CoV-2 patients with stage 3 acute renal failure

 

Comprehensive Role of SARS-CoV-2 Spike Glycoprotein in Regulating Host Signaling Pathway

29 April 2022 - In this review, we summarize the molecular mechanisms of interaction between S protein and host factors, especially receptor-mediated viral modulation of host signaling pathways, and highlight the progression on potential therapeutic targets, prophylactic and therapeutic agents for prevention and treatment of SARS-CoV-2 infection

 

Phosphate-regulated expression of the SARS-CoV-2 receptor-binding domain in the diatom Phaeodactylum tricornutum for pandemic diagnostics

29 April 2022 - Our study shows that P. tricornutum is a scalable system with minimal biocontainment requirements for the inducible production of SARS-CoV-2 or other coronavirus antigens for pandemic diagnostics

 

Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions

29 April 2022 - This treatment strategy could modulate host microbiota and mitigate virus-induced inflammation

 

The Role of Autologous Micrografts Injection from The Scalp Tissue in The Treatment of Covid-19 Associated Telogen Effluvium: Clinical and Trichoscopic Evaluation

29 April 2022 - Autologous micrograft of the scalp showed marked improvement in the treatment of COVID 19 Telogen effluvium

 

A raising dawn of pentoxifylline in management of inflammatory disorders in Covid-19

29 April 2022 - Taken together, PTX seems to be an effective agent against Covid-19 severity

 

Breakthrough SARS-CoV-2 infections with the delta (B.1.617.2) variant in vaccinated patients with immune-mediated inflammatory diseases using immunosuppressants: a substudy of two prospective cohort studies

29 April 2022 - The incidence and severity of SARS-CoV-2 breakthrough infections in patients with immune-mediated inflammatory diseases on immunosuppressants was similar to that in controls. However, caution might still be warranted for those on anti-CD20 therapy and those with traditional risk factors

 

Hyper inflammatory syndrome following COVID-19 mRNA vaccine in children: A national post-authorization pharmacovigilance study

29 April 2022 - Very few cases of hyper-inflammatory syndrome with multi-organ involvement occurred following COVID-19 mRNA vaccine in 12–17-year-old children. The low reporting rate of this syndrome, compared to the rate of post-SARS-CoV-2 MIS-C in the same age-group, largely supports the vaccination in a context of an important circulation of SARS-CoV-2

 

Nafamostat mesylate monotherapy in patients with moderate COVID-19 : A single-center retrospective study

28 April 2022

In conclusion, nafamostat mesylate monotherapy did not improve clinical outcomes in patients with moderate COVID-19. The therapeutic potential of the combination of nafamostat mesylate and other antiviral agents has not been examined in the present study, and further investigation is required. 

 

A method for the generation of pseudovirus particles bearing SARS coronavirus spike protein in high yields

28 April 2022

This improved VSV pseudovirus production method should facilitate studies of coronavirus entry and development of antiviral agents

 

Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19

20 April 2022 - A single dose of AZD7442 had efficacy for the prevention of Covid-19, without evident safety concerns

 

Effect of BTN162b2 and Coronavac boosters on humoral and cellular immunity of individuals previously fully vaccinated with Coronavac against SARS-CoV-2: A longitudinal study

19 April 2022 - For this purpose, we aimed to determine the effects of BNT162b2 (BNT) and CoronaVac (CV) boosters on the humoral and cellular immunity of individuals who had two doses of CV vaccination

 

Impact of previous exposure to SARS-CoV-2 and of S-Trimer (SCB-2019) COVID-19 vaccination on the risk of reinfection: a randomised, double-blinded, placebo-controlled, phase 2 and 3 trial

18 April 2022 - Previous exposure to SARS-CoV-2 decreased the risk and severity of subsequent COVID-19 infection, even against newly emerging variants. Protection is further enhanced by one or two doses of SCB-2019

 

An endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells

18 April 2022 - An endogenously activated IFNλ response, possibly due to genetic differences, may be one explanation for the differences in susceptibility to SARS-CoV-2 infection in humans. Importantly, our work supports the continued exploration of IFNλ as a potential pharmaceutical against SARS-CoV-2 infection

 

Vaccine effectiveness against SARS-CoV-2 infection and severe outcomes among individuals with immune-mediated inflammatory diseases tested between March 1 and Nov 22, 2021, in Ontario, Canada: a population-based analysis

14 April 2022 - Two vaccine doses were found to be highly effective against both SARS-CoV-2 infection and severe COVID-19 outcomes in patients with rheumatoid arthritis, ankylosing spondylitis, psoriasis, and inflammatory bowel disease during the study period. Research is needed to determine the durability of effectiveness of three doses over time, particularly against emerging variants

 

PipeCoV shows better performance when compared to well-established SARS-CoV-2 pipelines, with a lower content of Ns and higher genome coverage when compared to the Wuhan reference. It also provides a variant report not offered by other tested pipelines

14 April 2022 - Here, we discussed about various therapeutic agents, their clinical trials, and limitations of trials for the management of COVID-19. Further, we have also spotlighted different vaccines in research in combating COVID-19

 

Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19

14 April 2022 - Treatment of symptomatic Covid-19 with nirmatrelvir plus ritonavir resulted in a risk of progression to severe Covid-19 that was 89% lower than the risk with placebo, without evident safety concerns

 

Fourth Dose of BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting

13 April 2022 - A fourth dose of the BNT162b2 vaccine was effective in reducing the short-term risk of Covid-19–related outcomes among persons who had received a third dose at least 4 months earlier

 

PipeCoV: a pipeline for SARS-CoV-2 genome assembly, annotation and variant identification

13 April 2022 - PipeCoV shows better performance when compared to well-established SARS-CoV-2 pipelines, with a lower content of Ns and higher genome coverage when compared to the Wuhan reference. It also provides a variant report not offered by other tested pipelines

 

Dosing interval strategies for two-dose COVID-19 vaccination in 13 middle-income countries of Europe: Health impact modelling and benefit-risk analysis

11 April 2022 - We infer that longer dosing intervals of over six months could reduce COVID-19 mortality in MICs of Europe. Certain parameters, such as rapid waning of first-dose induced immunity and increased immune escape through the emergence of VOCs, could significantly shorten the optimal dosing intervals

 

Safety, tolerability, and immunogenicity of a SARS-CoV-2 recombinant spike RBD protein vaccine: A randomised, double-blind, placebo-controlled, phase 1-2 clinical trial (ABDALA Study)

09 April 2022 - The Abdala vaccine was safe, well tolerated, and induced humoral immune responses against SARS-CoV-2. These results, in the context of the emergency COVID-19 pandemic, support the 50 μg dose, applied in a 0-14-28 days schedule, for further clinical trials to confirm vaccine efficacy

 

Pathogenicity of SARS-CoV-2 Omicron (R346K) variant in Syrian hamsters and its cross-neutralization with different variants of concern

08 April 2022 - This preliminary data shows that Omicron (R346K) variant infection can produce moderate to severe lung disease similar to that of the Delta variant and the neutralizing antibodies produced in response to Omicron (R346K) variant infection shows poor neutralizing ability against other co-circulating SARS-CoV-2 variants like Delta which necessitates caution as it may lead to increased cases of reinfection

 

COVID-19 vaccine waning and effectiveness and side-effects of boosters: a prospective community study from the ZOE COVID Study

08 April 2022 - After 5 months, vaccine effectiveness remained high among individuals younger than 55 years. Booster doses restore vaccine effectiveness. Adverse reactions after booster doses were similar to those after the second dose. Homologous booster schedules had fewer reported systemic side-effects than heterologous boosters

 

Boosting of serum neutralizing activity against the Omicron variant among recovered COVID-19 patients by BNT162b2 and CoronaVac vaccines

07 April 2022 - Among individuals with prior COVID-19, one dose of BNT162b2 or two doses of CoronaVac could induce detectable serum Omicron NAb. Our result would be particularly important for guiding vaccine policies in countries with COVID-19 vaccine shortage

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

06 April 2022 - These findings taken together suggest that antibody-mediated SARS-CoV-2 uptake by monocytes/macrophages triggers inflammatory cell death that aborts production of infectious virus but causes systemic inflammation that contributes to COVID-19 pathogenesis

 

Protection by a Fourth Dose of BNT162b2 against Omicron in Israel

05 April 2022 - Rates of confirmed SARS-CoV-2 infection and severe Covid-19 were lower after a fourth dose of BNT162b2 vaccine than after only three doses. Protection against confirmed infection appeared short-lived, whereas protection against severe illness did not wane during the study period

 

Characterisation and natural progression of SARS-CoV-2 infection in ferrets

05 April 2022 -  Due to the absence of clinical signs after viral challenge, our ferret model is appropriate for studying asymptomatic SARS-CoV-2 infections and most suitable for use in vaccine efficacy studies

 

David versus goliath: ACE2-Fc receptor traps as potential SARS-CoV-2 inhibitors

05 April 2022 - This review summarizes different evolution platforms that have been used to enhance ACE2-Fc (i.e., immunoadhesins) as potential therapeutics for the current pandemic or future outbreaks of SARS-associated betacoronaviruses

 

SARS-CoV-2 BA.1 variant is neutralized by vaccine booster-elicited serum, but evades most convalescent serum and therapeutic antibodies

05 April 2022 - These findings underscore the potential benefit of mRNA vaccine boosters for protection against Omicron and the need for rapid development of antibody therapeutics that maintain potency against emerging variants

 

Identification of potential antivirals against 3CLpro enzyme for the treatment of SARS-CoV-2: A multi-step virtual screening study

05 April 2022 - The multi-step virtual screening analyses suggested that compounds CASAntiV-865453-58-3, CASAntiV-865453-40-3, and CASAntiV-2043031-84-9 could be used as effective therapeutic agents for the treatment of SARS-CoV-2

 

Neutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern

04 April 2022 - Our work show diminished neutralization potency against multiple variants in vaccine-elicited sera, which indicates the potential need for additional boost vaccinations

 

Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism

04 April 2022 - He discovered furin conformation offers new opportunities for structure-based drug Discovery

 

Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2

02 April 2022 - This knowledge could further help understanding SARS-CoV2 infection and anti-viral mechanisms of plant-based therapeutics

 

Efficacy, safety, and immunogenicity of the DNA SARS-CoV-2 vaccine (ZyCoV-D): the interim efficacy results of a phase 3, randomised, double-blind, placebo-controlled study in India

02 April 2022 - In this interim analysis, ZyCoV-D vaccine was found to be efficacious, safe, and immunogenic in a phase 3 trial

 

Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study

01 April 2022 - This could reflect appropriate clinical decision making, but the possibility of inequitable access to life-saving care should be considered

 

Induction of SARS-CoV-2 neutralizing antibodies by CoronaVac and BNT162b2 vaccines in naïve and previously infected individuals

01 April 2022 - The decay of nAbs titres in previously infected individuals over time indicates that vaccination is needed to boost humoral memory responses. Immunization of naïve individuals with two doses of CoronaVac induced nAbs titres that were significantly lower to that of convalescent patients, and similar to vaccination with one dose of BTN162b2

 

Telomere-length dependent T-cell clonal expansion: A model linking ageing to COVID-19 T-cell lymphopenia and mortality

31 March 2022 - Short HCTL might increase vulnerability of many older adults, and some younger individuals with inherently short HCTL, to COVID-19 T-cell lymphopenia and severe disease

 

Effectiveness of CoronaVac, ChAdOx1 nCoV-19, BNT162b2, and Ad26.COV2.S among individuals with previous SARS-CoV-2 infection in Brazil: a test-negative, case-control study

31 March 2022 - All four vaccines conferred additional protection against symptomatic infections and severe outcomes among individuals with previous SARS-CoV-2 infection. The provision of a full vaccine series to individuals after recovery from COVID-19 might reduce morbidity and mortality

 

BNT162b2 Protection against the Omicron Variant in Children and Adolescents

30 March 2022 - BNT162b2 vaccination reduced the risk of omicron-associated hospitalization by two thirds among children 5 to 11 years of age. Although two doses provided lower protection against omicron-associated hospitalization than against delta-associated hospitalization among adolescents 12 to 18 years of age, vaccination prevented critical illness caused by either variant

 

Early Outpatient Treatment for Covid-19 with Convalescent Plasma

30 March 2022 - In participants with Covid-19, most of whom were unvaccinated, the administration of convalescent plasma within 9 days after the onset of symptoms reduced the risk of disease progression leading to hospitalization

 

Effect of Early Treatment with Ivermectin among Patients with Covid-19

30 March 2022 - Treatment with ivermectin did not result in a lower incidence of medical admission to a hospital due to progression of Covid-19 or of prolonged emergency department observation among outpatients with an early diagnosis of Covid-19

 

Upstream cell culture process characterization and in-process control strategy development at pandemic speed

29 March 2022 - The strategies we present may be applied to accelerate late-stage process development for other biologics to reduce timelines

 

Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells

29 March 2022 - findings suggest that manipulation of Gal-9 should be explored as a therapeutic strategy for SARS-CoV-2 infection

 

Ruxolitinib in addition to standard of care for the treatment of patients admitted to hospital with COVID-19 (RUXCOVID): a randomised, double-blind, placebo-controlled, phase 3 trial

29 March 2022 - Ruxolitinib 5 mg twice per day showed no benefit in the overall study population. A larger sample is required to determine the clinical importance of trends for increased efficacy in patient subgroups

 

A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic

28 March 2022 - This demonstrates that TTSP-mediated proteolytic maturation of spike is critical for SARS-CoV-2 infection in vivo and suggests that N-0385 provides a novel effective early treatment option against COVID-19 and emerging SARS-CoV-2 VOCs

Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine

23 March 2022 - A third dose of the BNT162b2 vaccine administered a median of 10.8 months after the second dose provided 95.3% efficacy against Covid-19 as compared with two doses of the BNT162b2 vaccine during a median follow-up of 2.5 months.

 

SARS-CoV-2-specific antibody and T-cell responses 1 year after infection in people recovered from COVID-19: a longitudinal cohort study

23 March 2022 - This study suggests that cross-reactive SARS-CoV-2-specific T-cell responses could be particularly important in the protection against severe disease caused by variants of concern whereas neutralising antibody responses seem to reduce over time.

 

Eicosanoid signaling blockade protects middle-aged mice from severe COVID-19

21 March 2022 -Further, treatment with a PTGDR antagonist, asapiprant, protected aged mice from lethal infection. PTGDR antagonism is one of the first interventions in SARS-CoV-2-infected animals that specifically protects aged animals, suggesting that the PLA2G2D-PGD2/PTGDR pathway is a useful target for therapeutic interventions

 

Effectiveness of rAd26-rAd5, ChAdOx1 nCoV-19, and BBIBP-CorV vaccines for risk of infection with SARS-CoV-2 and death due to COVID-19 in people older than 60 years in Argentina: a test-negative, case-control, and retrospective longitudinal study

15 March 2022 - The vaccines used in Argentina showed effectiveness in reducing infection and death by SARS-CoV-2 and COVID-19

 

Effect of mRNA Vaccine Boosters against SARS-CoV-2 Omicron Infection in Qatar

09 March 2022 - The messenger RNA (mRNA) boosters were highly effective against symptomatic delta infection, but they were less effective against symptomatic omicron infection. However, with both variants, mRNA boosters led to strong protection against Covid-19–related hospitalization and death

Clinical frailty, and not features of acute infection, is associated with late mortality in COVID-19: a retrospective cohort study   

07 March 2022  - In our cohort, late mortality in COVID-19 patients is more strongly associated with premorbid clinical frailty than with severity of the acute infection phase.

 

When RING Finger Family Proteins meet SARS-CoV-2

07 March 2022 - In this mini-review, we discuss the diverse antiviral mechanisms of RNF proteins and viral immune evasion in an RNF proteins-dependent manner. Understanding the crosstalk between RNF proteins and SARS-CoV-2 infection would help design potential novel targets for COVID-19 treatment.

 

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Management of Mild-to-Moderate Symptomatic COVID-19

08 March 2022 - The pharmacological targets of these substances are described here for their possible synergism in counteracting SARS-CoV-2 replication and progression of the infection from the upper respiratory airways to the blood, avoiding vascular complications and cytokine and bradykinin storms

 

Monobodies with potent neutralizing activity against SARS-CoV-2 Delta and other variants of concern

7 March 2022 - The obtained monobodies would be useful as neutralizing proteins against current and potentially hazardous future SARS-CoV-2 variants

 

Infection control and the prevalence, management and outcomes of SARS-CoV-2 infections in mental health wards in London, UK: lessons learned from wave 1 to wave 2

08 March 2022 - Availability of infection control measures in line with a policy of parity of esteem between mental and physical health appears to have lowered within-hospital COVID-19 infections and deaths. Cautious management of vulnerable patient groups including mental health patients may reduce the future impact of COVID-19

 

Antimicrobial Peptides: A plausible approach for COVID-19 treatment

07 Mar 2022- Antiviral peptides are anticipated to be blockbuster drugs for the management of this serious infection because of their formulation and therapeutic advantages. Although they may act on different pathways, AVPs having a multi-targeted approach are considered to have the upper hand in the management of this infection

 

Effects and safety of COVID-19 vaccination on assisted reproductive technology and pregnancy: A comprehensive review and joint statements of the KSRM, the KSRI, and the KOSAR

February 22, 2022 - Accordingly, it is recommended that pregnant women receive COVID-19 vaccination. There is no rationale for adverse effects, or clinical cases of adverse reactions, in mothers or neonates after COVID-19 vaccination in lactating women. Instead, antibodies to SARS-CoV-2 can be delivered through breast milk. Therefore, breastfeeding mothers should consider vaccination. In summary, active administration of COVID-19 vaccines will help ensure the safe implementation of ART, pregnancy, and breastfeeding.

 

Inhibition of SARS-CoV-2 replication by zinc gluconate in combination with hinokitiol

1 March 2022 - Our studies provide the direct experimental evidence that elevated intracellular zinc concentration directly inhibits SARS-CoV-2 replication and suggest the potential benefits to use the zinc supplements for coronavirus disease 2019 (COVID-19) treatment.

 

The Anti-Coronavirus Therapy (ACT) trials: design, baseline characteristics, and challenges

1 March 2022 - The ACT trials will determine the efficacy of anti-inflammatory therapy with colchicine and antithrombotic therapy with aspirin given alone or in combination with rivaroxaban across the spectrum of mild, moderate, and severe COVID-19. Lessons learned from the conduct of these trials will inform planning of future trials

 

Optimizing peptide inhibitors of SARS-Cov-2 nsp10/nsp16 methyltransferase predicted through molecular simulation and machine learning

28 February 2022 - This results in the prediction that the H80R variant is a solid new candidate for potential new testing. We envision that this new lead is the beginning of a reputable foundation of a new computational method that combats coronaviruses and that is beneficial for new peptide drug development.

 

SARS-CoV-2 is associated with changes in brain structure in UK Biobank

07 March 2022 - These mainly limbic brain imaging results may be the in vivo hallmarks of a degenerative spread of the disease via olfactory pathways, of neuroinflammatory events, or of the loss of sensory input due to anosmia. Whether this deleterious impact can be partially reversed, or whether these effects will persist in the long term, remains to be investigated with additional follow up.

 

Whole genome sequencing reveals host factors underlying critical Covid-19

07 March 2022 - Our results are broadly consistent with a multi-component model of Covid-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication, or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between critically-ill cases and population controls is highly efficient for detection of therapeutically-relevant mechanisms of disease

 

Antibody evasion properties of SARS-CoV-2 Omicron sublineages

03 March 2022 - These findings indicate that these three sublineages of Omicron are antigenically equidistant from the wild-type SARS-CoV-2 and thus similarly threaten the efficacies of current vaccines. BA.2 also exhibited marked resistance to 17 of 19 neutralizing monoclonal antibodies tested, including S309 (sotrovimab)7, which had retained appreciable activity against BA.1 and BA.1+R346K2-4,6. This new finding shows that no authorized monoclonal antibody therapy could adequately cover all sublineages of the Omicron variant, except for the recently authorized LY-CoV1404 (bebtelovimab)

 

Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant

March 2, 2022Primary immunization with two doses of ChAdOx1 nCoV-19 or BNT162b2 vaccine provided limited protection against symptomatic disease caused by the omicron variant. A BNT162b2 or mRNA-1273 booster after either the ChAdOx1 nCoV-19 or BNT162b2 primary course substantially increased protection, but that protection waned over time

 

Population Immunity and Covid-19 Severity with Omicron Variant in South Africa

March 2, 2022 - Primary immunization with two doses of ChAdOx1 nCoV-19 or BNT162b2 vaccine provided limited protection against symptomatic disease caused by the omicron variant. A BNT162b2 or mRNA-1273 booster after either the ChAdOx1 nCoV-19 or BNT162b2 primary course substantially increased protection, but that protection waned over time.

 

Variation in the COVID-19 infection–fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis

February 24, 2022 - During the pre-vaccine period, the estimated 33% decrease in median IFR over 8 months suggests that treatment for COVID-19 has improved over time. Estimating IFR for the pre-vaccine era provides an important baseline for describing the progression of COVID-19 mortality patterns.

 

Nirmatrelvir plus ritonavir (Paxlovid) a potent SARS-CoV-2 3CLpro protease inhibitor combination

21 February 2022 - This antiviral would be effective against current and future viral variants, since 3CL is not modified in them. The FDA approved this antiviral in November 2021 and EMA is in the final evaluation phase

 

Molnupiravir: First Approval

20 February 2022 - This article summarizes the milestones in the development of molnupiravir leading to this first approval for COVID-19

 

Prevention, treatment and potential mechanism of herbal medicine for Corona viruses: A review

19 February 2022 - Future work basedon large-scale randomized, double-blind clinical trials to evaluate herbal medicines andtheir active ingredients in the treatment of new COVID-19 will be very meaningful

 

Evaluation of antibody response after two doses of the sinovac vaccine and the potential need for booster doses in cancer patients                                                                          

18 February 2022 - As a result, the expected antibody response was not obtained with two doses of the Sinovac vaccine. Therefore, if the Sinovac vaccine is to be preferred for these patients, the appropriate booster time for the 3rd dose should be determined or other vaccines, such as mRNA vaccines, with reported higher antibody responses should be considered

 

A Review on the New Indication of Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in the Treatment of Coronavirus Disease 2019

18 February 2022 - This review is principally focused on the mechanisms of NRTIs to introduce them as potential therapies for COVID-19. However, further in vitro and in vivo investigations will offer helpful information for the identification of drug candidates as a part of COVID-19 management

 

High titer of antibody against the SARS-CoV-2 spike protein among patients receiving neutralizing antibody cocktail therapy with REGN-COV

18 February 2022 - The high titer of IgGSP supports the clinical benefit of therapeutic and prophylactic use of REGN-COV from the serological point of view

 

Immune transcriptome analysis of COVID-19 patients infected with SARS-CoV-2 variants carrying the E484K escape mutation identifies a distinct gene module

18 February 2022 - Our study offers insights into distinct molecular immune responses elicited by SARS-CoV-2 variants carrying the E484K escape mutation throughout the COVID-19 disease

 

Hypothesis: How far are we from predicting multi-drug interactions during treatment for COVID-19 infection?

18 February 2022 - Whether or not this approach can be extended to other diseases is uncertain. Still, we believe it represents a valuable pharmacological insight to help improve clinical outcomes for severely ill patients

 

Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 

16 February 2022 - Treatment of symptomatic Covid-19 with nirmatrelvir plus ritonavir resulted in a risk of progression to severe Covid-19 that was 89% lower than the risk with placebo, without evident safety concerns

 

Effectiveness of the BNT162b2 Vaccine after Recovery from Covid-19

16 February 2022  - Among patients who had recovered from Covid-19, the receipt of at least one dose of the BNT162b2 vaccine was associated with a significantly lower risk of recurrent infection

 

Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection

16 February 2022 - Two doses of BNT162b2 vaccine were associated with high short-term protection against SARS-CoV-2 infection; this protection waned considerably after 6 months. Infection-acquired immunity boosted with vaccination remained high more than 1 year after infection

 

Bat coronaviruses related to SARS-CoV-2 and infectious for human cells

16 February /2022 - Our findings therefore indicate that bat-borne SARS-CoV-2-like viruses potentially infectious for humans circulate in Rhinolophus spp. in the Indochinese peninsula

 

Molecular docking studies of phytochemicals from Terminalia chebula for identification of potential multi-target inhibitors of SARS-CoV-2 proteins

16 February 2022 - We believe that our study has the potential to help the scientific communities to develop the multi-target drug from T. chebula to combat against the deadly pathogen SARS-COV-2 in future with the support of extensive wet lab analysis

 

Human/SARS-CoV-2 Genome-Scale Metabolic Modeling to Discover Potential Antiviral Targets for COVID-19

15 February 2022 - Our predictions also indicate that CTP and UTP inhibition blocks viral RNA replication through a similar mechanism to that of molnupiravir

 

The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics

15 February 2022 - Our study reports a breakthrough in both the development of a novel nose organoid model and in our understanding of the host cellular response to RSV and SARS-CoV-2 infection

 

Inhibition of Protein N-Glycosylation Blocks SARS-CoV-2 Infection 

15 February 2022 - As new SARS-CoV-2 variants, with various degrees of resistance against current vaccines, are likely to continue appearing, halting virus glycosylation using repurposed human drugs could result in a complementary strategy to reducing the spread of COVID-19 worldwide

 

Genome-Wide Characterization of SARS-CoV-2 Cytopathogenic Proteins in the Search of Antiviral Targets

15 February 2022 - Since cellular oxidative stress and inflammation contribute to cell death and tissue damage linked to the severity of COVID-19, our findings suggest that ORF3a is a promising, novel therapeutic target against COVID-19

 

Monoclonal antibody therapies in the management of SARS-CoV-2 infection

14 February 2022 - This article highlights the accelerated regulatory processes established to facilitate the review and approval of potential therapies. An overview of treatment approaches for SARS-CoV-2 infection, with detailed examination of the preclinical and clinical evidence supporting the use of NAbs, is provided

 

Stapled peptides as potential inhibitors of SARS-CoV-2 binding to the hACE2 receptor

14 February 2022 - Several independent research initiatives have investigated the inhibitory effect of stapled peptides on binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, to its receptor, angiotensin-converting-enzyme 2 (ACE2). These stapled peptides, which mimic Helix 1 of the human ACE2 receptor, have demonstrated mixed ability to prevent infection with SARS-CoV-2 in cell-based studies

 

Generation time of the alpha and delta SARS-CoV-2 variants: an epidemiological analysis

14 February 2022 - The delta variant transmits more quickly in households than the alpha variant, which can be attributed to faster depletion of susceptible individuals in households and a possible decrease in the intrinsic generation time. Interventions such as contact tracing, testing, and isolation might be less effective if transmission of the virus occurs quickly

 

Identifying absorbable bioactive constituents of yupingfeng powder acting on COVID-19 through integration of UPLC-Q/TOF-MS and network pharmacology analysis

09 February 2022 - The approach of combining UPLC-Q/TOF-MS with network pharmacology is an effective tool to identify potentially bioactive constituents of YPF and its key targets on treatment of COVID-19

 

Severe COVID-19 during pregnancy treated with pulse corticosteroid therapy and mid-trimester termination: A case report

09 February 2022 - Due to the specific immune response, pregnant women with COVID-19 may differ from others in their clinical presentation, especially the probability of classic acute respiratory distress syndrome (ARDS). This report provides evidence related to the efficacy of pulse corticosteroids on this group and the influence of the mid-trimester termination on recovery

 

Final Analysis of Efficacy and Safety of Single-Dose Ad26.COV2.S

09 February 2022 - A single dose of Ad26.COV2.S provided 52.9% protection against moderate to severe–critical Covid-19. Protection varied according to variant; higher protection was observed against severe Covid-19, medical intervention, and death than against other end points and lasted for 6 months or longer

Antibody profiles in COVID-19 convalescent plasma prepared with Amotosalen/UVA pathogen reduction treatment

06 February 2022 - The findings of this study support the selection of effective CCP combined with use of A/UVA-PRT in the production of CCP for patients with COVID-19

 

Risk of infection, hospitalisation, and death up to 9 months after a second dose of COVID-19 vaccine: a retrospective, total population cohort study in Sweden

04 February 2022 - We found progressively waning vaccine effectiveness against SARS-CoV-2 infection of any severity across all subgroups, but the rate of waning differed according to vaccine type. With respect to severe COVID-19, vaccine effectiveness seemed to be better maintained, although some waning became evident after 4 months

 

Discovery of novel TMPRSS2 inhibitors for COVID-19 using in silico fragment-based drug design, molecular docking, molecular dynamics, and quantum mechanics studies

02 February 2022 - Because the androgen-responsive serine protease TMPRSS2 is involved in cleaving the SARS-CoV-2 spike protein allowing the virus to enter the cell, therefore, direct TMPRSS2 inhibition will inhibit virus activation and disease progression which make it an important target for drug discovery

 

Effect of an antiviral drug control and its variable order fractional network in host COVID-19 kinetics

01 February 2022 - In this article, we propose a mathematical model for examining the effects of antiviral treatment over viral mutation to control disease transmission. We have considered here three populations namely uninfected epithelial cells, infected epithelial cells, and SARS-CoV-2 virus

 

Advances in the development of therapeutic strategies against COVID-19 and perspectives in the drug design for emerging SARS-CoV-2 variants

31 January 2022 - Therefore, it is highly acclaimed the requirements of the concerted efforts from multi-disciplinary basic studies and clinical trials, which improves the accurate treatment of COVID-19 and optimizes the contingency measures to emerging SARS-CoV-2 variants

 

The Effect of Phytocompounds of Medicinal Plants on Coronavirus (2019-NCOV) Infection

31 January 2022 - the bioactive compounds such as phenols, flavonoids, monoterpenes, and phenylpropanoids, derived from several herbs such as Eucalyptus globulus, Mentha spicata, Nigella sativa, Rosmarinus officinalis, Thymus capitatus and Zingiber officinale could be used to develop formal drugs against several diseases with no or minimal side effects

 

Comparative pathology of the nasal epithelium in K18-hACE2 Tg mice, hACE2 Tg mice, and hamsters infected with SARS-CoV-2

29 January 2022 - Moreover, viral RNA was abundant in the cerebrum of K18-hACE2 Tg mice, including the olfactory bulb. The K8-hACE2 Tg mouse, hACE2 Tg mouse, and hamster models could be used to investigate the pathology of SARS-CoV-2 infection in the upper respiratory tract and central nervous system. These models could help to provide a better understanding of the pathogenic process of this virus and to develop effective medications and prophylactic treatments

 

Human genetic and immunological determinants of critical COVID-19 pneumonia

28 January 2022 - The TLR3- and TLR7-dependent production of type I IFNs by respiratory epithelial cells and plasmacytoid dendritic cells, respectively, is essential for host defense against SARS-CoV-2. In ways that can depend on age and sex, insufficient type I IFN immunity in the respiratory tract during the first few days of infection may account for the spread of the virus, leading to pulmonary and systemic inflammation

 

Homologous and Heterologous Covid-19 Booster Vaccinations

26 January 2022 - Homologous and heterologous booster vaccines had an acceptable safety profile and were immunogenic in adults who had completed a primary Covid-19 vaccine regimen at least 12 weeks earlier

 

The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment

25 January 2022 - In this review, we provide an overview of the role of TMPRSS2 in the entry processes of different respiratory viruses. We then review the different classes of TMPRSS2 inhibitors and their clinical development, with a focus on COVID-19 treatment

 

Potential Genes Associated with COVID-19 and Comorbidity

24 January 2022 - The study provides a basis for further investigation of genes and pathways with predictive value for the risk of infection and prognosis and could help guide drug and vaccine development to improve treatment efficacy and the development of personalised treatments, especially for COVID-19 individuals with common comorbidities

Heterologous versus homologous COVID-19 booster vaccination in previous recipients of two doses of CoronaVac COVID-19 vaccine in Brazil (RHH-001): a phase 4, non-inferiority, single blind, randomised study

21 January 2022 - Antibody concentrations were low at 6 months after previous immunisation with two doses of CoronaVac. However, all four vaccines administered as a third dose induced a significant increase in binding and neutralising antibodies, which could improve protection against infection. Heterologous boosting resulted in more robust immune responses than homologous boosting and might enhance protection

 

Immunogenicity and Reactogenicity of Vaccine Boosters after Ad26.COV2.S Priming

19 January 2022 - The Ad26.COV2.S and mRNA boosters had an acceptable safety profile and were immunogenic in health care workers who had received a priming 

dose of Ad26.COV2.S vaccine. The strongest responses occurred after boosting with mRNA-based vaccines. Boosting with any available vaccine was better than not boosting

 

Computational screening of camostat and related compounds against human TMPRSS2: A potential treatment of COVID-19

19 January 2022 - Following a sequential in-depth molecular docking and dynamics simulation, we report the compounds that exhibited promising efficacy against TMPRSS2. The molecular docking and MM/PBSA free energy calculation study indicates these compounds carry excellent binding affinity against TMPRSS2 and found them more effective than camostat

 

Mitochondrial Dysfunction Associates With Acute T Lymphocytopenia and Impaired Functionality in COVID-19 Patients

14 January 2022 - Our findings demonstrated an MD-associated mechanism underlying SARS-CoV-2-induced T lymphocytopenia and functional impairment during the acute phase of infection

 

Persistent Oxidative Stress and Inflammasome Activation in CD14highCD16− Monocytes From COVID-19 Patients

14 January 2022 - Those cells also showed aberrant levels of mitochondrial superoxide and lipid peroxidation, both hallmarks of the oxidative stress response, which strongly correlated with caspase-1 activity. In addition, we found that NLRP3 inflammasome-derived IL-1β secretion by SARS-CoV-2-exposed monocytes in vitro was partially dependent on lipid peroxidation. Importantly, altered inflammasome and stress responses persisted after short-term patient recovery. Collectively, our findings suggest oxidative stress/NLRP3 signaling pathway as a potential target for host-directed therapy to mitigate early COVID-19 hyperinflammation and also its long-term outcomes

 

SARS-CoV-2 Infection and Active, Multiorgan, Severe cGVHD After HSCT for Adolescent ALL: More Luck Than Understanding? A Case Report

14 January 2022 - Surprisingly, despite severe lymphopenia the patient developed SARS-CoV-2-specific antibodies within 15 days, which was followed by clearance of SARS-CoV-2 and EBV with resolution of symptoms. Thereafter, parameters of immune dysregulation such as lymphopenia and B-cell dyshomeostasis, the latter characterised by elevated CD21low B cells and autoantibody expression, normalised. Moreover, we observed complete response of active chronic GvHD to treatment

 

ACE2 Shedding and the Role in COVID-19

14 January 2022 - Elevated concentrations of sACE2 are more related to disease. Recombinant human ACE2, an exogenous soluble ACE2, can be used to supplement endogenous ACE2. It may represent a potent COVID-19 treatment in the future. However, the specific administration concentration needs to be further investigated

 

Methylprednisolone accelerate chest computed tomography absorption in COVID-19: A three-centered retrospective case control study from China

14 January 2022 - Low-to-moderate dose short-term methylprednisolone can accelerate the chest CT imaging absorption of COVID-19 so as to improve symptoms and alleviate the condition in a short term, reduce the hospital stay, meanwhile avoid severe COVID-19 phases. The protocol has been proven to be effective and safe in clinical use

 

Angiotensin II Infusion in COVID-19: An International, Multicenter, Registry-based Study

14 January 2022 - Within the limitations of such a study design, our findings confirm previous observations of a potentially positive effect of ANGII on blood pressure and FiO2 but no effect on patient-centered outcomes

 

Multiple evanescent white dot syndrome following vaccination for COVID-19

14 January 2022 - Multiple evanescent white dot syndrome (MEWDS) is an acute, usually unilateral, retinal disorder of unknown etiology that predominantly occurs in healthy young women

 

An Updated Review of Porcine Deltacoronavirus in Terms of Prevalence, Pathogenicity, Pathogenesis and Antiviral Strategy

13 January 2022 - In this review, we summarize the current knowledge on the prevalence, pathogenicity and infection dynamics, pathogenesis and immune evasion strategies of PDCoV. The existing anti-PDCoV strategies and corresponding mechanisms of PDCoV infection are also introduced, aiming to provide suggestions for the prevention and treatment of PDCoV and zoonotic diseases

 

Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection

13 January 2022 - Combinations of the inflammatory mediators IFN-β, PTX3, IFN-γ, IFN-λ2/3 and IL-6 associated with LC with 78.5–81.6% accuracy. This work defines immunological parameters associated with LC and suggests future opportunities for prevention and treatment

 

Potential therapeutic options for COVID-19: an update on current evidence

13 January  2022 - The present study summarized current evidence of these therapeutic approaches to assess their efficacy and safety for COVID-19 treatment

 

Metabolic and Immune Markers for Precise Monitoring of COVID-19 Severity and Treatment

12 January 2022 - Our results show that high-dimensional metabolomic and joint immune-metabolic readouts provide rich information content for elucidation of the host’s response to infection and empower discovery of novel metabolic-driven therapies, as well as precise and efficient clinical action

 

DNA Based Vaccine Expressing SARS-CoV-2 Spike-CD40L Fusion Protein Confers Protection Against Challenge in a Syrian Hamster Model

12 January 2022 - These results collectively indicate that this DNA vaccine candidate could be further explored because of its efficacy and known safety profile

 

Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents

12 January 2022 - Among hospitalized adolescent patients, two doses of the BNT162b2 vaccine were highly effective against Covid-19–related hospitalization and ICU admission or the receipt of life support

 

Duration of Protection against Mild and Severe Disease by Covid-19 Vaccines

12 January 2022 - We observed limited waning in vaccine effectiveness against Covid-19–related hospitalization and death at 20 weeks or more after vaccination with two doses of the ChAdOx1-S or BNT162b2 vaccine

 

Effectiveness of Covid-19 Vaccines over a 9-Month Period in North Carolina

12 January /2022 - All three Covid-19 vaccines had durable effectiveness in reducing the risks of hospitalization and death. Waning protection against infection over time was due to both declining immunity and the emergence of the delta variant

 

Antiviral activity of 5-aminolevulinic acid against variants of severe acute respiratory syndrome coronavirus 2

07 January 2022 - Our study suggests that 5-ALA with SFC warrants accelerated clinical evaluation as an antiviral drug candidate for treating patients infected with SARS-CoV-2 variants

 

Double-blind placebo-controlled randomized clinical trial to assess the efficacy of montelukast in mild to moderate respiratory symptoms of patients with long COVID: E-SPERANZA COVID Project study protocol

06 January 2022 - To evaluate the efficacy of 10 mg oral montelukast every 24 h versus placebo in improving quality of life associated with mild to moderate respiratory symptoms in patients with long COVID as measured with the COPD Assessment Test (CAT) questionnaire

 

Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro

06 January 2022 - Our data suggested that obatoclax should be further explored as clinical drug for the treatment of COVID-19

 

The societal economic value of COVID-19 vaccines in the United States

06 January 2022 - The magnitude of economic benefit from vaccination highlights the need for coordinated policy decisions to support continued widespread vaccine uptake in the US

 

Neutralizing antibody: a savior in the Covid-19 disease 

06 January 2022 - In this review, we have discussed details about neutralizing antibodies and their role in combating Covid-19 disease

 

Effect of Covid-19 Vaccination on Transmission of Alpha and Delta Variants

05 January 2022 - Vaccination was associated with a smaller reduction in transmission of the delta variant than of the alpha variant, and the effects of vaccination decreased over time. PCR Ct values at diagnosis of the index patient only partially explained decreased transmission

 

Vaccine-induced massive pulmonary embolism and thrombocytopenia following a single dose of Janssen ad26.cov2.s vaccination

01 January 2022 - Treatment with intravenous immunoglobulins, however, could mask the ability of anti-PF4-heparin antibodies to bind and activate platelets in the presence of heparin, leading to false negative results at the immunoassay functional test. Therefore, if VITT is suspected, blood samples for diagnostic confirmation should be collected prior to any treatment to improve diagnostic performance

 

Evolution of enhanced innate immune evasion by SARS-CoV-2

23 December 2021 - The importance of mutations outside Spike in adaptation of SARS-CoV-2 to humans is underscored by the observation that similar mutations exist in the Delta and Omicron N/Orf9b regulatory regions

 

Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients

22 December 2021 - Among nonhospitalized patients who were at high risk for Covid-19 progression, a 3-day course of remdesivir had an acceptable safety profile and resulted in an 87% lower risk of hospitalization or death than placebo

 

Characterization of the novel SARS-CoV-2 Omicron (B.1.1.529) Variant of Concern and its global perspective

14 December 2021 - Collectively, our data suggests that due to continuous variation in the spike glycoprotein structures, the use of coronavirus specific attachment inhibitors may not be the current choice of therapy for emerging SARS-CoV-2 VOCs. Hence, we need to proceed with a sense of urgency in this matter

 

High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain

14 December 2021 - Our study demonstrates the feasibility of identifying selective inhibitors based on ADP-ribosylhydrolase activity, paving the way for the screening of large compound libraries to identify improved macrodomain inhibitors and to explore their potential as antiviral therapies for SARS-CoV-2 and future viral threats

 

Controlling the Burden of COVID-19 by Manipulating Host Metabolism

13 December 2021 - Manipulating metabolic activities to control the outcome of COVID-19 has to date received minimal attention. Manipulating host metabolism will never replace vaccines to control COVID-19 but could be used as an adjunct therapy to the extent of ongoing infection

 

Baricitinib combination therapy: a narrative review of repurposed Janus kinase inhibitor against severe SARS-CoV-2 infection

13 December 2021 - Baricitinib plus the standard of care treatment might be a potential strategy in hospitalized patients with severe COVID-19

 

The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression

10 December 2021 - OM-85 inhibits SARS-CoV-2 epithelial cell infection in vitro by downregulating SARS-CoV-2 receptor expression. Further studies are warranted to assess whether OM-85 may prevent and/or reduce the severity of COVID-19

 

Modulation of the Conformational Space of SARS-CoV-2 RNA Quadruplex RG-1 by Cellular Components and the Amyloidogenic Peptides α-Synuclein and hIAPP

09 December 2021 - These results may therefore shed more light on the relationship between PD as well as T2DM and the SARS-CoV-2 disease and their molecular underpinnings. Since dysregulation of G4Q formation by rationally designed targeting compounds affects the control of cellular processes, this study should contribute to the development of specific ligands for intervention 

 

BNT162b2 Vaccine Booster and Mortality Due to Covid-19

08 December 2021 - Participants who received a booster at least 5 months after a second dose of BNT162b2 had 90% lower mortality due to Covid-19 than participants who did not receive a booster

 

Protection against Covid-19 by BNT162b2 Booster across Age Groups

08 December 2021 - Across the age groups studied, rates of confirmed Covid-19 and severe illness were substantially lower among participants who received a booster dose of the BNT162b2 vaccine than among those who did not

 

Effect of Crizanlizumab, a P-Selectin Inhibitor, in COVID-19: A Placebo-Controlled, Randomized Trial

08 December 2021 - There were no significant differences between crizanlizumab and placebo for clinical endpoints. Crizanlizumab was well tolerated. Crizanlizumab may induce thrombolysis in the setting of COVID-19

 

The emergence, genomic diversity and global spread of SARS-CoV-2

08 December 2021 - More broadly, we highlight our currently limited understanding of coronavirus diversity in nature, the rapid spread of the virus and its variants in such an increasingly connected world, the reduced protection of vaccines, and the urgent need for coordinated global surveillance using genomic techniques

 

VDA-RWLRLS: An anti-SARS-CoV-2 drug prioritizing framework combining an unbalanced bi-random walk and Laplacian regularized least squares

07 December 2021- Integrating unbalanced bi-random walks, Laplacian regularized least squares, molecular docking, and molecular dynamics simulation, this work initially screened a few anti-SARS-CoV-2 drugs and may contribute to preventing COVID-19 transmission

Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infection

7 December 2021 - Tracking individual clones of SARS-CoV-2-specific CD8+ T cells, we reveal that an interferon signature marks clones giving rise to long-lived cells, whereas prolonged proliferation and mammalian target of rapamycin (mTOR) signaling are associated with clonal disappearance from the blood. Collectively, we describe a transcriptional signature that marks long-lived, circulating human memory CD8+ T cells following an acute virus infection

 

Inactivated Whole-virus Vaccine Triggers Low Response Against SARS-CoV-2 Infection Among Renal Transplant Patients

07 December 2021 - CoronaVac vaccine was associated with low reactogenicity, low immunogenicity but reduced incidence of COVID-19 among kidney transplant recipients. The lack of reduction in lethality rates is perhaps associated with the low percentage of patients developing humoral response after the second dose 

 

Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial

06 December 2021 - Heterologous second dosing with m1273, but not NVX, increased transient systemic reactogenicity compared with homologous schedules. Multiple vaccines are appropriate to complete primary immunisation following priming with BNT or ChAd, facilitating rapid vaccine deployment globally and supporting recognition of such schedules for vaccine certification                                                   

Computational Simulation of HIV Protease Inhibitors to the Main Protease (Mpro) of SARS-CoV-2: Implications for COVID-19 Drugs Design

5 December 2021 - Pharmacophore model analysis further revealed that the aromatic ring, hydrogen bond donor, and hydrophobic group are the essential infrastructure of Mpro inhibitors. Overall, this study applied computational simulation methods to study the interaction mechanism of HIV-1 protease inhibitors with SARS-CoV-2 Mpro, and the findings provide useful insights for the development of novel anti-SARS-CoV-2 agents for the treatment of COVID-19

 

Understanding the clinical utility of favipiravir (T-705) in coronavirus disease of 2019: a review

04 December 2021 - This review provides evidence-based insights and throws light on the current clinical trials examining the efficacy of favipiravir in tackling COVID-19, including its mechanism, pharmacodynamics, and pharmacokinetics  

 

A randomised controlled trial testing the efficacy of Fit after COVID, a cognitive behavioural therapy targeting severe post-infectious fatigue following COVID-19 (ReCOVer): study protocol 

02 December 2021 - This is the first trial testing a cognitive behavioural intervention targeting severe fatigue after COVID-19. If Fit after COVID is effective in reducing fatigue severity following COVID-19, this intervention could contribute to alleviating the long-term health consequences of COVID-19 by relieving one of its most prevalent and distressing long-term symptoms

 

Spherical Neutralizing Aptamer Inhibits SARS-CoV-2 Infection and Suppresses Mutational Escape

02 December 2021 - Overall, the SNAP strategy provides a new direction for the development of antivirus agents against SARS-CoV-2 and other emerging coronaviruses

 

In-silico screening of naturally derived phytochemicals against SARS-CoV Main protease

02 December 2021 - This study paves the way towards discovering a lead used in the treatment of COVID-19 from natural sources and introduces phytomedicines with dual therapeutic effects against COVID-19 besides their original pharmacological effects

 

Study of immune-mediated mechanisms in patients tested positive for SARS-CoV-2: phenotypic and functional analysis of monocytes, NK and T cells in the blood of subjects affected by COVID 19

02 December 2021 - The proof of a role of these immunological phenomena on the development of COVID-19 are bases for implementation of therapeutic immunomodulatory treatments

 

Drug Repurposing strategies and key challenges for Covid-19 management

02 December 2021 - The key benefit of drug repurposing is drug is the wealth of information related to its safety, and easy accessibility. Altogether allows for quick access to regulatory approval as well as sophisticated clinical studies

 

Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19

01 December 2021 - Molecular docking simulations reveal the binding modes of C1 in the dimer interface and substrate-binding pocket of the target. In addition, C1 shows outstanding metabolic stability in the gastrointestinal tract, human plasma, and human liver microsome, suggesting that this agent has the potential to be developed as an orally administrated SARS-CoV-2 3CLpro inhibitor

 

Immune-mediated neurological syndrome in SARS-CoV-2 infection: a review of literature on autoimmune encephalitis in COVID-19

01 December 2021 - Autoimmune encephalitis can occur via three possible proposed pathophysiological mechanism and can manifest during or after the acute infection period. It is more common in adult but can also occur in the paediatric patients. There were various spectra of autoantibody panels reported including antineuronal antibody, anti-gangliosides antibody and onconeural antibody. Majority of the patients responded well to the immunomodulating therapy and achieved good recovery

 

Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2

01 December 2021 - A screen of known viroporin inhibitors on Protein E, ORF7b, ORF10 and Protein 3a from SARS-CoV-2 revealed inhibition of Protein E and ORF7b by emodin and xanthene, the latter also blocking Protein 3a. This illustrates a general potential of well-known ion channel blockers against SARS-CoV-2 and specifically a dual molecular basis for the promising effects of amantadine in COVID-19 treatment

 

Comparative Effectiveness of BNT162b2 and mRNA-1273 Vaccines in U.S. Veterans

01 December 2021 - The 24-week risk of Covid-19 outcomes was low after vaccination with mRNA-1273 or BNT162b2, although risks were lower with mRNA-1273 than with BNT162b2. This pattern was consistent across periods marked by alpha- and delta-variant predominance

 

Covid-19 Vaccine Effectiveness in New York State

01 December 2021 - The effectiveness of the three vaccines against Covid-19 declined after the delta variant became predominant. The effectiveness against hospitalization remained high, with modest declines limited to BNT162b2 and mRNA-1273 recipients 65 years of age or older

 

Fluoxetine use is associated with improved survival of patients with COVID-19 pneumonia: A retrospective case-control study

30 November 2021 - Provisional to confirmation in randomised controlled studies, fluoxetine may be a potent treatment increasing the survival for COVID-19 pneumonia

 

Involvement of the ACE2/Ang-(1–7)/MasR Axis in Pulmonary Fibrosis: Implications for COVID-19 

30 November 2021 - This review aimed to characterize the ACE2-Ang-(1–7)-MasR Axis in the context of pulmonary fibrosis with an emphasis on risk factors, including the SARS-CoV-2 virus and exposure to environmental toxicants. In the context of the pandemic, there is a dire need for an understanding of pulmonary fibrotic events. More research is needed to understand the interplay between ACE2, pulmonary fibrosis, and susceptibility to coronavirus infection

 

Antimicrobial and Antiviral (SARS-CoV-2) Potential of Cannabinoids and Cannabis sativa: A Comprehensive Review

28 November 2021 - The therapeutic potential of cannabinoids as anti-inflammatory compounds is hypothesized for the treatment of COVID-19. However, more systemic investigations are warranted to establish the best efficacy and their toxic effects, followed by preclinical trials on a large number of participants

 

Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation

25 November 2021  - Our data suggest that the P681R mutation is a hallmark of the virological phenotype of the B.1.617.2/Delta variant and is associated with enhanced pathogenicity

 

The N501Y spike substitution enhances SARS-CoV-2 infection and transmission

24 November 2021  - The N501Y substitution recapitulated the phenotype of enhanced viral transmission seen with the combined 8 Alpha spike mutations, suggesting it is a major determinant of increased transmission of this variant. Mechanistically, the N501Y substitution improved the affinity of the viral spike protein for cellular receptors. As suggested by its convergent evolution in Brazil, South Africa, and elsewhere2,3, our results indicate that N501Y substitution is a major adaptive spike mutation of major concern

 

Monoclonal antibody treatment for COVID-19 in solid organ transplant recipients

17 November 2021 - Our experience suggests that MAB treatment, with respect to the available MAB formulations and circulating viral variants present during our study period, may provide favorable outcomes for mild to moderate COVID-19 in SOT recipients.

 

Retrospective Analysis of Clinical Laboratory Parameters, Therapeutics and Outcome in Patients Infected with SARS-CoV2

17 November 2021 - When Tocilizumab and Remdisivir were administered together, 44.0% of patients survived while 56% expired. 79.7% of patients survived while 20.3% expired when neither Tocilizumab nor Remdesivir was administered.

 

Organ-specific genome diversity of replication-competent SARS-CoV-2

17 November 2021 - Our results provide insights about the pathogenesis and intra-host evolution of SARS-CoV-2 and show that COVID-19 treatment and hygiene measures need to be tailored to specific needs of immunocompromised patients, even when respiratory symptoms cease

 

SARS-CoV-2 Variants and Their Relevant Mutational Profiles: Update Summer 2021

17 November 2021 - Overall, this review sheds light and assists in defining the genetic signatures characterizing the currently circulating variants and their clinical relevance.

 

Optimization of Non-Coding Regions for a Non-Modified mRNA COVID-19 Vaccine

17 November 2021 - These data demonstrate that optimization of non-coding regions can greatly improve the immunogenicity and protective efficacy of a non-modified mRNA SARS-CoV-2 vaccine in nonhuman primates.

 

Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

November 17, 2021 - In patients hospitalised with COVID-19, aspirin was not associated with reductions in 28 day mortality or in the risk of progressing to invasive mechanical ventilation or death, but was associated with a small increase in the rate of being discharged alive within 28 days.

 

Safety, immunogenicity, and efficacy of a COVID-19 vaccine (NVX-CoV2373) co-administered with seasonal influenza vaccines: an exploratory substudy of a randomised, observer-blinded, placebo-controlled, phase 3 trial

November 17, 2021 - To our knowledge, this substudy is the first to show the safety, immunogenicity, and efficacy profile of a COVID-19 vaccine when co-administered with seasonal influenza vaccines. Our results suggest concomitant vaccination might be a viable immunisation strategy.

 

Two years into COVID-19 – Lessons in SARS-CoV-2 and a perspective from papers in FEBS Letters

16 November 2021- Here, I highlight the recent COVID-19 papers which have been published and collected in a Virtual Issue in FEBS Letters, and discuss their implications towards understanding the molecular, biochemical and cellular mechanisms of SARS-CoV-2 infections, vaccine development and antiviral discovery strategies

 

Suramin, penciclovir, and anidulafungin exhibit potential in the treatment of COVID-19 via binding to nsp12 of SARS-CoV-2

16 Nov 2021 - Such evidence, along with the significant and varied physical interactions of these drugs with the key viral enzyme outlined in this investigation, indicates that they might have a prospective therapeutic potential in the treatment of COVID-19 as monotherapy or combination therapy with Remdesivir

 

COMPARISON OF REMDESIVIR AND FAVIPIRAVIR - THE ANTI-COVID-19 AGENTS MIMICKING PURINE RNA CONSTITUENTS

November 15, 2021 - The goal of this work is to summarize the information available on two antimetabolites - remdesivir and favipiravir - and to compare clinical experience obtained so far with these two agents in COVID-19 patients.

 

The role of microRNAs in solving COVID-19 puzzle from infection to therapeutics: A mini-review

14 November 2021 - Accordingly, miRNAs represent potential biomarkers and therapeutic targets for this devastating viral disease. Therefore, in this current review, we present the recent discoveries regarding the clinical relevance and biological roles of miRNAs in COVID-19

 

Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial

November 11, 2021 - Concomitant vaccination with ChAdOx1 or BNT162b2 plus an age-appropriate influenza vaccine raises no safety concerns and preserves antibody responses to both vaccines. Concomitant vaccination with both COVID-19 and influenza vaccines over the next immunisation season should reduce the burden on health-care services for vaccine delivery, allowing for timely vaccine administration and protection from COVID-19 and influenza for those in need.

 

Efficacy, safety, and lot-to-lot immunogenicity of an inactivated SARS-CoV-2 vaccine (BBV152): interim results of a randomised, double-blind, controlled, phase 3 trial

November 11, 2021 - BBV152 was highly efficacious against laboratory-confirmed symptomatic COVID-19 disease in adults. Vaccination was well tolerated with no safety concerns raised in this interim analysis.

 

Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age

November 9, 2021 - A Covid-19 vaccination regimen consisting of two 10-μg doses of BNT162b2 administered 21 days apart was found to be safe, immunogenic, and efficacious in children 5 to 11 years of age.

 

Estimating the early impact of the US COVID-19 vaccination programme on COVID-19 cases, emergency department visits, hospital admissions, and deaths among adults aged 65 years and older: an ecological analysis of national surveillance data

03 November 2021 - The initial roll-out of the US COVID-19 vaccination programme was associated with reductions in COVID-19 cases, emergency department visits, and hospital admissions among older adults

 

Phenylethanoid glycosides as a possible COVID-19 protease inhibitor: a virtual screening approach

03 November 2021 - This kinase inhibitory activity is very beneficial in fighting viruses inside the body as kinases are required for viral entry, metabolism, and/or reproduction. The dual activity (kinase/protease) of phenylethanoid glycosides makes them very promising anit-COVID-19 agents

 

Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids

03 November 2021 - Dasabuvir’s inhibitory effect was also demonstrated in the cases of SARS-CoV-2 and RVA infection, highlighting the usefulness of the HIE platform for screening antiviral agents against various viruses that target the intestines

 

Corticosteroid treatment in COVID-19 modulates host inflammatory responses and transcriptional signatures of immune dysregulation 

03 November 2021 - Overall, these data suggest that inflammation and cell death are key drivers of severe COVID-19 pathogenesis in the absence of corticosteroid therapy

 

Safety and immunogenicity of ChAdOx1 MERS vaccine candidate in healthy Middle Eastern adults (MERS002): an open-label, non-randomised, dose-escalation, phase 1b trial

03 November 2021 - The acceptable safety and immunogenicity data from this phase 1b trial of ChAdOx1 MERS vaccine candidate in Healthy Middle Eastern adults, combined with previous safety and immunogenicity data from a trial in the UK, support selecting the ChAdOx1 MERS vaccine for advancement into phase 2 clinical evaluation

 

Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction

02 November 2021 - Overall, the findings suggested that HO-1, induced by hemin, effectively suppressed SARS-CoV-2 in vitro. Therefore, HO-1 could be potential therapeutic candidate for COVID-19

 

Absent antibody production following COVID19 vaccination with mRNA in patients under immunosuppressive treatments

1 November 2021 - Thus, it is important to inform immunosuppressed patients about the risk of vaccine non-responsiveness and the necessity to maintain non-pharmaceutical protection measures. In these risk patients antibody testing and cellular analysis are helpful to estimate the benefit/responsiveness to further booster vaccinations

 

Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study

October 29, 2021 - Our findings suggest that a third dose of the BNT162b2 mRNA vaccine is effective in protecting individuals against severe COVID-19-related outcomes, compared with receiving only two doses at least 5 months ago.

 

Immunology and controlling of coronaviruses; the current enemy for humanity: A review 

31 October 2021 - The potential of antibodies, natural metabolites, and current suggest vaccines were applied to the face of this new threat

 

Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study

29 October 2021 - Our findings suggest that a third dose of the BNT162b2 mRNA vaccine is effective in protecting individuals against severe COVID-19-related outcomes, compared with receiving only two doses at least 5 months ago

Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study

29 October 2021 - Primary outcomes for the viral load kinetics analysis were to detect differences in the peak viral load, viral growth rate, and viral decline rate between participants according to SARS-CoV-2 variant and vaccination status 

 

Antimicrobial prescription in severe COVID-19 and CAP: a matched case-control study

28 October 2021 - In severe coronavirus diseases 2019 (COVID-19), a high and potentially excessive use of antimicrobials for suspected bacterial co-infection and intensive care unit (ICU)-acquired infections has been repeatedly reported

 

Waning Immunity after the BNT162b2 Vaccine in Israel

27 October 2021 - These findings indicate that immunity against the delta variant of SARS-CoV-2 waned in all age groups a few months after receipt of the second dose of vaccine

 

Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab

27 October 2021 - Among high-risk patients with mild-to-moderate Covid-19, sotrovimab reduced the risk of disease progression. No safety signals were identified

 

Non-pharmaceutical interventions, vaccination, and the SARS-CoV-2 delta variant in England: a mathematical modelling study

27 October 2021 - Our findings show that the risk of a large wave of COVID-19 hospital admissions resulting from lifting NPIs can be substantially mitigated if the timing of NPI relaxation is carefully balanced against vaccination coverage

 

Distinct Roles of Type I and Type III Interferons During a Native Murine β Coronavirus Lung Infection

27 October 2021 - This study demonstrates distinct roles and potency of type I and type III interferons and their therapeutic potential during coronavirus lung infection

 

Successful treatment of severe COVID-19 pneumonia with tocilizumab: A series of three cases

27 October 2021 - In this research letter, 3 consecutive patients are presented with severe COVID-19 pneumonia who between January and March 2021 were successfully treated with tocilizumab (a humanized antibody to the soluble interleukin-6 receptor) added to the standard therapy

 

Non-pharmaceutical interventions, vaccination, and the SARS-CoV-2 delta variant in England: a mathematical modelling study

27 October 2021 - Our findings show that the risk of a large wave of COVID-19 hospital admissions resulting from lifting NPIs can be substantially mitigated if the timing of NPI relaxation is carefully balanced against vaccination coverage

 

Cerebral venous sinus thrombosis after ChAdOx1 vaccination: the first case of definite thrombosis with thrombocytopenia syndrome from India

27 October 2021 - Early recognition of adenoviral vector vaccine-related TTS, which resembles heparin-induced thrombocytopenia syndrome, is important as heparin and heparin analogues are best avoided in the treatment

 

Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab

27 October 2021 - Among high-risk patients with mild-to-moderate Covid-19, sotrovimab reduced the risk of disease progression. No safety signals were identified

 

COVID-19 mRNA Vaccine-induced Pneumonitis: A Case Report

26 October 2021 - The timing of the onset of pneumonitis after vaccination and the results of intradermal testing suggest that Type IV hypersensitivity against COVID-19 vaccine may have been responsible for this clinical condition

 

Nanoparticle approaches against SARS-CoV-2 infection

25 October 2021 - Overall, nanoparticles bring numerous new opportunities to improve our response to the current COVID-19 pandemic and enhance our preparedness for future viral outbreaks

 

Cryptic transmission of SARS-CoV-2 and the first COVID-19 wave

25 October 2021 - Our approach complements phylogenetic analyses and other surveillance approaches and provides insights that can be used to design innovative, model-driven surveillance systems that guide enhanced testing and response strategies

 

Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells

25 October 2021 - Our data reveal that untimely production of TGFβ is a hallmark of severe COVID-19 and may inhibit NK cell function and early virus control 

 

Immunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination

21 October 2021 - The ChAdOx1-S-nCoV-19 vaccine induced a weaker IgG response but a stronger T cell response than the BNT162b2 vaccine after the priming dose, which could explain the complementarity of both vaccines when used in combination. The heterologous vaccination regimen could therefore be particularly suitable for immune compromised individuals

 

Immunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination

21 October 2021 - The heterologous vaccination regimen could therefore be particularly suitable for immune compromised individuals

 

Refractory vaccine-induced immune thrombotic thrombocytopenia (VITT) managed with delayed therapeutic plasma exchange (TPE)

21 October 2021 - A delayed therapeutic plasma exchange (TPE) was pursued on day 32 of admission as salvage therapy, with a sustained improvement in his platelet count. Our case serves as proof-of-concept of the efficacy of TPE in VITT

 

Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening

20 October 2021 - Overall, these results highlight the potential of single B cell screening for the rapid and reliable identification of high-affinity, potent neutralizing antibodies for infectious disease applications

 

COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models

20 October 2021 - Our findings demonstrate that COVA1-18 has a strong antiviral activity in three preclinical models and could be a valuable candidate for further clinical evaluation

 

Hybrid immunity improves B cells and antibodies against SARS-CoV-2 variants

20 October 2021 - Our data suggest that people that are seropositive following infection or primary vaccination will produce antibodies with increased potency and breadth and will be able to better control SARS-CoV-2 emerging variants

 

Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammatio

18 October 2021 - Our data show that neutralizing mAbs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure

 

An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection

14 October 2021 - Together, a high content screen coupled with transcriptome and metabolic profiling reveals a key role of the HIF1α-glycolysis axis in mediating SARS-CoV-2 infection of human airway epithelium

 

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

14 October 2021 - Its epitope defines a promising target for the development of a pan-sarbecovirus vaccine

 

SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy

13 October 2021 - Monoclonal antibody 5B8, targeting the cryptic inflammatory fibrin epitope, inhibited thromboinflammation. Our results reveal a procoagulant role for the SARS-CoV-2 Spike and propose fibrin-targeting interventions as a treatment for thromboinflammation in COVID-19

 

Structural Basis of a Human Neutralizing Antibody Specific to the SARS-CoV-2 Spike Protein Receptor-Binding Domain

13 October 2021 - These results provide a new human-sourced neutralizing antibody against the S-RBD and assist vaccine development

 

Selective Inhibition of the Interaction between SARS-CoV-2 Spike S1 and ACE2 by SPIDAR Peptide Induces Anti-Inflammatory Therapeutic Responses

13 October 2021 - Selective targeting of SARS-CoV-2 spike S1-to-ACE2 interaction by wtSPIDAR may be beneficial for coronavirus disease 2019

 

Molecular Insights of SARS-CoV-2 Infection and Molecular Treatments

13 October 2021 - Despite the limited availability of literatures, our attempt in this work to provide a relatively comprehensive overview of current SARS-CoV-2 studies can be helpful for quickly acquiring the key information of COVID-19 and further promoting this important research to control and diminish the pandemic

 

Dexamethasone for treating SARS-CoV-2 infection: a systematic review and meta-analysis

11 October 2021 - This study suggests that dexamethasone may significantly improve the outcome among hospitalized patients with SARS-CoV-2 infection and associated severe respiratory complications. ­Further studies need to consider both dose-dependent administration and outcomes in early and later stages of the disease

 

Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity

11 October 2021 - While both groups retained neutralization capacity against all variants, plasma from previously infected vaccinated individuals displayed overall better neutralization capacity when compared to plasma from uninfected individuals that also received two vaccine doses, pointing to vaccine boosters as a relevant future strategy to alleviate the impact of emerging variants on antibody neutralizing activity

 

Vitamin D supplementation to treat SARS-CoV-2 positive patients. Evidence from meta-analysis

08 October 2021 - Vitamin D supplementation in SARS-CoV-2 positive patients has the potential to positively impact patients with both mild and severe symptoms

 

Potent and Selective Covalent Inhibitors of the Papain-like Protease from SARS-CoV-2

08 October 2021 - These findings present an opportunity for further development of potent and selective covalent PLpro inhibitors

 

Anti-SARS-CoV-2 receptor binding domain antibody evolution after mRNA vaccination

07 October 2021 - These results suggest that boosting vaccinated individuals with currently available mRNA vaccines will increase plasma neutralizing activity but may not produce antibodies with equivalent breadth to those obtained by vaccinating convalescent individuals

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective

07 October 2021 - This experimental paradigm is essential to the discovery and development of therapeutics targeting viral polymerases

 

Anti-SARS-CoV-2 receptor binding domain antibody evolution after mRNA vaccination

07 October 2021 - These results suggest that boosting vaccinated individuals with currently available mRNA vaccines will increase plasma neutralizing activity but may not produce antibodies with equivalent breadth to those obtained by vaccinating convalescent individuals

 

Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months 

06 October 2021 - Six months after receipt of the second dose of the BNT162b2 vaccine, humoral response was substantially decreased, especially among men, among persons 65 years of age or older, and among persons with immunosuppression

 

Waning of BNT162b2 Vaccine Protection against SARS-CoV-2 Infection in Qatar

06 October 2021 - BNT162b2-induced protection against SARS-COV-2 infection appeared to wane rapidly following its peak after the second dose, but protection against hospitalization and death persisted at a robust level for 6 months after the second dose

 

Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel

06 October 2021 - The incidence of myocarditis, although low, increased after the receipt of the BNT162b2 vaccine, particularly after the second dose among young male recipients. The clinical presentation of myocarditis after vaccination was usually mild

 

Myocarditis after Covid-19 Vaccination in a Large Health Care Organization

06 October 2021 - Among patients in a large Israeli health care system who had received at least one dose of the BNT162b2 mRNA vaccine, the estimated incidence of myocarditis was 2.13 cases per 100,000 persons; the highest incidence was among male patients between the ages of 16 and 29 years. Most cases of myocarditis were mild or moderate in severity

 

A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration

05 October 2021 - Nb15-NbH-Nb15, a trimer constituted of three Nbs, is constructed to be bispecific for human serum albumin (HSA) and RBD of SARS-CoV-2. Nb15-NbH-Nb15 exhibits single-digit ng/ml neutralization potency against the wild-type and Delta variants of SARS-CoV-2 with a long half-life in vivo. In addition, we show that intranasal administration of Nb15-NbH-Nb15 provides effective protection for both prophylactic and therapeutic purposes against SARS-CoV-2 infection in transgenic hACE2 mice. Nb15-NbH-Nb15 is a potential candidate for both the prevention and treatment of SARS-CoV-2 through respiratory administration

 

Defining the Innate Immune Responses for SARS-CoV-2-Human Macrophage Interactions

04 October 2021 - We conclude that the SARS-CoV-2-infected host mounts a robust innate immune response characterized by a pro-inflammatory storm heralding end-organ tissue damage

 

Cost-Effectiveness of Baricitinib Compared With Standard of Care: A Modeling Study in Hospitalized Patients With COVID-19 in the United States

03 October 2021 - These findings were robust to sensitivity analysis and to conservative assumptions limiting the clinical benefits of baricitinib to the statistically significant reduction in mortality demonstrated in the COV-BARRIER trial

 

Viral polymerase binding and broad-spectrum antiviral activity of molnupiravir against human seasonal coronaviruses

02 October 2021 -The combination of molnupiravir with the protease inhibitor GC376 resulted in enhanced antiviral activity

 

Inhibitory Effects and Surface Plasmon Resonance-Based Binding Affinities of Dietary Hydrolyzable Tannins and Their Gut Microbial Metabolites on SARS-CoV-2 Main Protease

29 September 2021 - They inhibited SARS-CoV-2 Mpro (by 6.6–100.0% at 50 μM) and bound directly to the Mpro protein (with dissociation constants from 1.1 × 10–6 to 5.3 × 10–5 M). This study sheds light on the inhibitory effects of tannins and their metabolites on SARS-CoV-2 Mpro

 

Multifaceted anti-viral therapeutic potential of dietary flavonoids: emerging trends and future perspectives

29 September 2021 - The article would certainly provide a lead to the scientific community for the effective therapeutic antiviral use of flavonoids using potential cost-effective tools for improvement of the pharmacokinetics, bioavailability and bio-distribution of such compounds for the concrete action along with the promotion of human health

 

COVID-19 hospital admissions and deaths after BNT162b2 and ChAdOx1 nCoV-19 vaccinations in 2·57 million people in Scotland (EAVE II): a prospective cohort study

29 September 2021 - COVID-19 hospitalisations and deaths were uncommon 14 days or more after the first vaccine dose in this national analysis in the context of a high background incidence of SARS-CoV-2 infection and with extensive social distancing measures in place

 

Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine

29 September 2021 - AZD1222 was safe and efficacious in preventing symptomatic and severe Covid-19 across diverse populations that included older adults

 

REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19

29 September 2021 - REGEN-COV reduced the risk of Covid-19–related hospitalization or death from any cause, and it resolved symptoms and reduced the SARS-CoV-2 viral load more rapidly than placebo

 

Pimenta dioica (L.) Merr. Bioactive Constituents Exert Anti-SARS-CoV-2 and Anti-Inflammatory Activities: Molecular Docking and Dynamics, In Vitro, and In Vivo Studies

27 September 2021 - Our results could be promising for more advanced preclinical and clinical studies especially on rutin 2 either alone or in combination with other isolates for COVID-19 management

 

Titers of SARS CoV-2 antibodies in cord blood of neonates whose mothers contracted SARS CoV-2 (COVID-19) during pregnancy and in those whose mothers were vaccinated with mRNA to SARS CoV-2 during pregnancy

25 September 2021 - Neonates born to mothers vaccinated during pregnancy have higher antibody titers and may therefore have more prolonged protection than those born to women infected during pregnancy

 

SARS-CoV-2 mucosal antibody development and persistence and their relation to viral load and COVID-19 symptoms

23 September 2021 - Although serological studies have shown that antibodies against SARS-CoV-2 play an important role in protection against (re)infection, the dynamics of mucosal antibodies during primary infection and their potential impact on viral load and the resolution of disease symptoms remain unclear

 

No significant benefit of moderate-dose vitamin C on severe COVID-19 cases

22 September 2021 - Our findings revealed that in patients with severe COVID-19, treatment with moderate dose of intravenous vitamin C had no significant benefit on reducing the risk of death and obtaining clinical improvement

 

Remdesivir use and outcomes during the FDA COVID-19 emergency use authorization period

22 September 2021 - Time to RDV initiation appeared to affect recovery and 28-day mortality, a finding that should be explored further. Mortality rate decreased over the analysis period, which could be related to dexamethasone use and improved management of COVID-19

 

Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase

22 September 2021 - The mRNA-1273 vaccine continued to be efficacious in preventing Covid-19 illness and severe disease at more than 5 months, with an acceptable safety profile, and protection against asymptomatic infection was observed. (Funded by the Biomedical Advanced Research and Development Authority and the National Institute of Allergy and Infectious Diseases; COVE ClinicalTrials.gov number, NCT04470427

 

Infections, hospitalisations, and deaths averted via a nationwide vaccination campaign using the Pfizer–BioNTech BNT162b2 mRNA COVID-19 vaccine in Israel: a retrospective surveillance study

22 September 2021 - Without the national vaccination campaign, Israel probably would have had triple the number of hospitalisations and deaths compared with what actually occurred during its largest wave of the pandemic to date, and the health-care system might have become overwhelmed. Indirect effects and long-term benefits of the programme, which could be substantial, were not included in these estimates and warrant future research

 

Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus

21 September 2021 - The results clearly indicate the effectiveness of fatty acylation to improve the half-life of RDV

 

New Insights Into Drug Repurposing for COVID-19 Using Deep Learning 

21 September 2021 - Its ability can also be extended to repurpose drugs for other complex diseases, develop appropriate treatment strategies for new diseases, and provide precision medical treatment to patients, thus paving the way to discover new drugs that can potentially be effective for treating COVID-19

 

COVID-19 and the Cardiovascular System: Insights into Effects and Treatments

21 September 2021 - The development of new guidelines for effective treatment strategies requires concerted efforts to refine our understanding of the mechanisms underlying cardiovascular disease and large-scale clinical trials to reduce the burden of COVID-19 hospitalization and mortality.

 

Low-dose radiation therapy for COVID-19 pneumonia: a pilot study

21 September 2021 - The results of our pilot study suggest that LDRT is feasible in COVID-19 patients having moderate to severe disease. Its clinical efficacy may be tested by conducting randomized controlled trials.

 

The critical role of mesenchymal stromal/stem cell therapy in COVID-19 patients: An updated review

20 September 2021 - Accordingly, in this paper, we will focus on the therapeutic impacts of MSCs and their critical role in cytokine storm of COVID-19 patients

 

Multi-level inhibition of coronavirus replication by chemical ER stress

20 September 2021 - To investigate how CoVs modulate ER stress components at the mRNA compared to the protein level, we determined the expression levels of 166 components of the ER stress pathway KEGG hsa04141 “protein processing in ER” in human HuH7 liver cells, a commonly used cellular model for CoV replication, in response to infections with HCoV-229E and MERS-CoV, respectively

 

Anti-SARS-CoV-2 IgG and IgA antibodies in COVID-19 convalescent plasma do not facilitate antibody-dependent enhance of viral infection

16 September 2021 - These observations support the absence of antibody-dependent enhancement of infection (ADE) by IgG and IgA isotypes found in CCP

 

Immune and cellular damage biomarkers to predict COVID-19 mortality in hospitalized patients

16 September 2021 - The features that had the greatest impact on this model's prediction were age, LDH, platelets, and %lymphocytes, more than comorbidities or inflammation markers, and these findings were highly consistent in both datasets, likely reflecting the virus effect at the very beginning of the disease

 

Assessment of the binding interactions of SARS-CoV-2 spike glycoprotein variants

16 September 2021 - To understand the impact of spike protein mutations on the binding interactions required for virus infection and the effectiveness of neutralizing monoclonal antibody (mAb) therapies, the binding activities of the original spike protein receptor binding domain (RBD) sequence and the reported spike protein variants were investigated using surface plasmon resonance (SPR)

 

Novel ACE2 protein interactions relevant to COVID-19 predicted by evolutionary rate correlations

15 September 2021 - We propose that ACE2 has novel protein interactions that are disrupted during SARS-CoV-2 infection, contributing to the spectrum of COVID-19 pathologies

 

Safety and immunogenicity of an inactivated COVID-19 vaccine, BBIBP-CorV, in people younger than 18 years: a randomised, double-blind, controlled, phase 1/2 trial 

15 September 2021 - The inactivated COVID-19 vaccine BBIBP-CorV is safe and well tolerated at all tested dose levels in participants aged 3–17 years

 

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months 

15 September 2021 - Through 6 months of follow-up and despite a gradual decline in vaccine efficacy, BNT162b2 had a favorable safety profile and was highly efficacious in preventing Covid-19

 

Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel

15 September 2021 - In this study involving participants who were 60 years of age or older and had received two doses of the BNT162b2 vaccine at least 5 months earlier, we found that the rates of confirmed Covid-19 and severe illness were substantially lower among those who received a booster (third) dose of the BNT162b2 vaccine

 

Neglected roles of IgG Fc-binding protein secreted from airway mucin-producing cells in protecting against SARS-CoV-2 infection

15 September 2021 - The Fcγbp-mediated mechanism can be a key factor in explaining why SARS-CoV-2 is less infective/lethal in children, and may also be involved in the unique Ab response, recurrent infection, and effects of serum therapy and vaccination

 

New-onset IgG autoantibodies in hospitalized patients with COVID-19

14 September 2021 - We conclude that SARS-CoV-2 causes development of new-onset IgG autoantibodies in a significant proportion of hospitalized COVID-19 patients and are positively correlated with immune responses to SARS-CoV-2 proteins

 

Pneumonia-targeted lopinavir/ritonavir-based treatment for patients with COVID-19: an early-period retrospective single center observational study

14 September 2021 - Early, pneumonia targeted LPV/r-based antiviral therapy resulted in a significantly higher probability of negative conversion of PCR within 28 days compared to symptomatic treatment

 

Safety and efficacy of different prophylactic anticoagulation dosing regimens in critically and non-critically ill patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials

14 September 2021 - Our findings provide comprehensive and high-quality evidence for the use of standard-dose prophylactic anticoagulation over an escalated-dose regimen as routine standard of care for hospitalized patients with COVID-19 who do not have an indication for therapeutic anticoagulation, irrespective of disease severity

 

Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy

14 September 2021 - These data define the nature of the SARS-CoV-2 vaccine-induced immune landscape in aCD20-treated patients and provide insights into coordinated mRNA vaccine-induced immune responses in humans

 

Effectiveness of mRNA Covid-19 Vaccine among U.S. Health Care Personnel 

14 September 2021 - The BNT162b2 and mRNA-1273 vaccines were highly effective under real-world conditions in preventing symptomatic Covid-19 in health care personnel, including those at risk for severe Covid-19 and those in racial and ethnic groups that have been disproportionately affected by the pandemic

 

ASGARD: A Single-cell Guided pipeline to Aid Repurposing of Drugs

14 September 2021 - The top-ranked drugs, such as fulvestrant and neratinib for breast cancer, tretinoin and vorinostat for leukemia, and chloroquine and enalapril for severe COVID19, are either approved by FDA or in clinical trials treating corresponding diseases. In conclusion, ASGARD is a promising pipeline guided by single-cell RNA-seq data, for repurposing personalized drugs and drug combinations

 

Randomized Double-blind Placebo-controlled Proof-of-concept Trial of Resveratrol for Outpatient Treatment of Mild Coronavirus Disease (COVID-19)

13 September 2021 - This underpowered study was limited by small sample size and low incidence of primary adverse events. A larger trial could determine efficacy

 

Implementation and outcomes of monoclonal antibody infusion for COVID-19 in an inner-city safety net hospital: A South-Bronx experience

11 September 2021 - MAT reduced both hospitalization and mortality in this predominantly Hispanic patient population with mild to moderate COVID-19 with high risk factors for disease progression

 

COVID-19 and low-dose radiation therapy

10 September 2021 - This review aims to summarize the potential rationales and mechanisms of LDR therapy for COVID-19 patients, and its current clinical status and potential use

 

Vaccination reduces need for emergency care in breakthrough COVID-19 infections: A multicenter cohort study

9 September 2021 - Accounting for the SARS-CoV-2 vaccination population groups in Michigan, the ED encounters/hospitalizations rate relevant to COVID-19 was 96% lower in FV versus UV (multiplicative effect:0.04, 95% CI 0.03 to 0.06, p < 0.001) in negative binomial regression

 

Effects of adding L-arginine orally to standard therapy in patients with COVID-19: A randomized, double-blind, placebo-controlled, parallel-group trial. Results of the first interim analysis

9 September 2021 - In this interim analysis, adding oral L-arginine to standard therapy in patients with severe COVID-19 significantly decreases the length of hospitalization and reduces the respiratory support at 10 but not at 20 days after starting the treatment

 

Bioactive Molecules Derived from Snake Venoms with Therapeutic Potential for the Treatment of Thrombo-Cardiovascular Disorders Associated with COVID-19

09 September 2021 - This review aims to: (1) present an overview on the infection, the developed thrombo-inflammatory responses and mechanisms of induced thrombosis of COVID-19 compared to other similar pathogenesis; (2) underline the role of natural compounds such as anticoagulant, antiplatelet and thrombolytic agents; (3) investigate the management of coagulopathy related to COVID-19 and provide insight on therapeutic such as venom compounds

 

Inhibitors of L-Type Calcium Channels Show Therapeutic Potential for Treating SARS-CoV-2 Infections by Preventing Virus Entry and Spread

09 September 2021 - In an attempt to accelerate drug repurposing, we tested a panel of L-type calcium channel blocker (CCB) drugs currently developed for other conditions to determine whether they would inhibit SARS-CoV-2 infection in cell culture. All the CCBs tested showed varying degrees of inhibition, with felodipine and nifedipine strongly limiting SARS-CoV-2 entry and infection in epithelial lung cells at concentrations where cell toxicity was minimal

 

Dynamic IgG seropositivity after rollout of CoronaVac and BNT162b2 COVID-19 vaccines in Chile: a sentinel surveillance study

09 September 2021 - IgG seropositivity was lower after CoronaVac than after BNT162b2 and declined over time since vaccination for CoronaVac recipients but not BNT162b2 recipients. Prolonged IgG monitoring will allow further evaluation of seropositivity overtime, providing data, in conjunction with effectiveness studies, for possible future re-assessment of vaccination strategies

 

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

09 September 2021 - An open-label, randomized controlled trial of convalescent plasma for adults with COVID-19 receiving oxygen within 12 d of respiratory symptom onset (NCT04348656)

 

The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology

09 September 2021 - To prepare for the next phase of the pandemic, a systematic approach is needed to link global genomic surveillance and timely assessment of the phenotypic characteristics of novel variants, which will support the development and updating of diagnostics, vaccines, therapeutics and nonpharmaceutical interventions

 

Anthraquinolone and quinolizine derivatives as an alley of future treatment for COVID-19: an in silico machine learning hypothesis

09 September 2021 - Subsequently, these studies outcome were supported through simulation trajectories that further proved anthraquinolone and quinolizine derivatives as potential small molecules to be tested experimentally in treating COVID-19 patients

 

Immunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccines

09 September 2021 - Dominant linear epitopes were identified in the C-terminal domains of the S1 and S2 subunits (aa 558–569, 627–638, and 1148–1159) which have been previously associated with SARS-CoV-2 neutralization in vitro and demonstrate identity to bat coronavirus and SARS-CoV, but limited homology to non-pathogenic human coronavirus. The identified COVID-19 mRNA vaccine epitopes should be considered in the context of variants, immune escape and vaccine and therapy design moving forward

 

Retrospective analysis of anti-inflammatory therapies during the first wave of COVID-19 at a community hospital

09 September 2021 - This analysis demonstrated the survival benefit associated with anti-inflammatory therapy of GC, with or without tocilizumab, with the combination providing the most benefit. More studies are needed to assess the optimal timing of anti-inflammatory therapy initiation

 

Effect of Tocilizumab in Mortality among Patients with Severe and Critical Covid-19: Experience in a Third-Level Medical Center

08 September 2021 - In our study, tocilizumab was not associated with decreased hospital mortality among patients with severe COVID-19

 

Effectiveness of Covid-19 Vaccines in Ambulatory and Inpatient Care Settings

08 September 2021 - Covid-19 vaccines in the United States were highly effective against SARS-CoV-2 infection requiring hospitalization, ICU admission, or an emergency department or urgent care clinic visit. This vaccine effectiveness extended to populations that are disproportionately affected by SARS-CoV-2 infection

 

Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons

08 September 2021 - Calculated proportions of adverse pregnancy and neonatal outcomes in persons vaccinated against Covid-19 who had a completed pregnancy were similar to incidences reported in studies involving pregnant women that were conducted before the Covid-19 pandemic

Discovery of novel inhibitors of SARS-CoV-2 main protease

02 September 2021 - Corona Virus Disease 2019 (COVID-19), referred to as ‘New Coronary Pneumonia’, is a type of acute infectious disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection

 

Pseudoephedrine and its derivatives antagonize wild and mutated severe acute respiratory syndrome-CoV-2 viruses through blocking virus invasion and antiinflammatory effect

01 September 2021 - We further analyzed the blocking effect of the active compounds on the interactions of mutated S-RBD and ACE2 by computational studies. Moreover, antiinflammatory activities were evaluated using qRT-PCR, enzyme-linked immune sorbent assay, and Western blot analysis

 

In-silico strategies to combat COVID-19: A comprehensive review

01 September 2021 - We have focused on designing a comprehensive review on in-silico approaches concerning COVID-19 to discuss the relevant bioinformatics and computational resources, tools, patterns of research, outcomes generated so far and their future implications to efficiently model data based on epidemiology; identify drug targets to design new drugs; predict epitopes for vaccine design and conceptualize diagnostic models

 

Are laboratory-made, COVID-19-specific monoclonal antibodies an effective treatment for COVID-19?

September 2021 - BackgroundMonoclonal antibodies (mAbs) are laboratory-produced molecules derived from the B cells of an infected host. They are being investigatedas a potential therapy for coronavirus disease 2019 (COVID-19)

 

Development of Effective Therapeutic Molecule from Natural Sources against Coronavirus Protease

30 August 2021 - Through in silico approach, selected flavonoids were docked into the active site of Mpro. The free energies of the ligands complexed with Mpro were computationally estimated using the molecular mechanics-generalized Born surface area (MM/GBSA) method. In addition, the inhibition process of SARS-CoV-2 Mpro with these ligands was simulated at 100 ns in order to uncover the dynamic behavior and complex stability

 

Metoprolol in Critically Ill Patients With COVID-19

30 August 2021 - Severe coronavirus disease-2019 (COVID-19) can progress to an acute respiratory distress syndrome (ARDS)

 

GalNAc-siRNA conjugates: Prospective tools on the frontier of anti-viral therapeutics

30 August 2021 - The growing use of short-interfering RNA (siRNA)-based therapeutics for viral diseases reflects the most recent innovations in anti-viral vaccines and drugs

 

Utility of various inflammatory markers in predicting outcomes of hospitalized patients with COVID-19 pneumonia A single-center experience

30 August 2021 - Judicious use of COVID-19 biomarkers could help in disease prognostication and thereby provide guidance to devise appropriate management strategies

 

Receptor-binding domain of SARS-CoV-2 spike protein efficiently inhibits SARS-CoV-2 infection and attachment to mouse lung

28 August 2021 - These findings indicate that RBD protein could be used for the prevention and treatment of SARS-CoV-2 infection

 

The rapid adaptation of SARS-CoV-2–rise of the variants: transmission and resistance

27 August 2021 - The causative factor of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously mutating

 

Covid-19 post-infectious acute transverse myelitis responsive to corticosteroid therapy: report of two clinical cases

27 August 2021 - SARS-COV-2 infection has affected millions of individuals with a wide range of clinical manifestations, including central and peripheral nervous systems through several mechanisms

 

Use of Thiols in the Treatment of COVID-19: Current Evidence

27 August 2021 - There is a possible role for oxidative stress, a state characterized by an altered balance between the production of free radicals or reactive oxygen species (ROS) and antioxidant defences, in coronavirus disease 2019 (COVID-19), the genesis of which is quite complex

 

MD simulation and MM/PBSA identifies phytochemicals as bifunctional inhibitors of SARS-CoV-2

27 August 2021 - The global spread of SARS-CoV-2 has resulted in millions of fatalities worldwide, making it crucial to identify potent antiviral therapeutics to combat this vírus

 

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19

26 August 2021 - Thrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19)

 

Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting

25 August 2021 - Preapproval trials showed that messenger RNA (mRNA)–based vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had a good safety profile, yet these trials were subject to size and patient-mix limitations

 

Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations        

24 August 2021 - Our study elucidated in detail the binding mechanism of the potent PF-07321332 to 3CLpro along with the low potency of lopinavir and ritonavir due to weak binding affinity demonstrated by the binding energy data. This study will be helpful for the development and optimization of more specific compounds to combat coronavirus disease

 

The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis           

24 August 2021 - To determine the molecular mechanism of multiple organ dysfunction, a bioinformatics analysis method based on a time-order gene co-expression network (TO-GCN) was performed

 

Tocilizumab: A retrospective multi-center cohort study of critically ill patients with COVID-19

August 2021 - Coronavirus disease 19 (COVID-19) can have a severe presentation characterized by a dysregulated immune response requiring admission to the intensive care unit (ICU)

 

Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial

10 August 2021 - A previous efficacy trial found benefit from inhaled budesonide for COVID-19 in patients not admitted to hospital, but effectiveness in high-risk individuals is unknown

 

Bioactive recombinant human oncostatin M for NMR-based screening in drug discovery                                                                                                 

10 August 2021 - To pursue a high-throughput screening and structure-based drug discovery strategy to design a small molecule inhibitor of OSM, milligram quantities of highly pure, bioactive OSM are required

 

Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study                                                                

10 August 2021 - In this report we summarize the IMPACC study design and protocols including clinical criteria and recruitment, multi-site standardized sample collection and processing, virologic and immunologic assays, harmonization of assay protocols, high-level analyses and the data sharing plans

 

Remdesivir in the COVID-19 Pandemic: An Analysis of Spontaneous Reports in VigiBase During 2020                                                                           

10 August 2021 - This study aimed to provide a descriptive analysis of COVID-19 ICSR data focusing on remdesivir, including a disproportionality analysis (DA) of ADRs

 

A nanotechnological approach in the current therapy of COVID-19: model drug oseltamivir-phosphate loaded PLGA nanoparticles targeted with spike protein binder peptide of SARS-CoV-2                                                                                      

10 August 2021 - In this study, it is aimed to develop a biocompatible and biodegradable polymeric drug delivery system that is targeted to the relevant receptor binding site and provides controlled drug release

 

Longitudinal analysis to characterize classes and subclasses of antibody responses to recombinant receptor-binding protein (RBD) of SARS-CoV-2 in COVID-19 patients in Thailand                                                                                  

10 August 2021 - This study aimed to characterize the classes and subclasses of antibody responses to a recombinant receptor-binding protein (RBD) of SARS-CoV-2 in COVID-19 patients and investigated the reactivity of these antibodies in patients with other tropical infections and healthy individuals in Thailand

 

A Narrative Review of the Clinical Practicalities of Bamlanivimab and Etesevimab Antibody Therapies for SARS-CoV-2                                                  

10 August 2021 - While vaccines remain the primary option for COVID-19 prevention, neutralizing monoclonal antibodies (mAbs), such as bamlanivimab and etesevimab, have been shown to benefit certain subpopulations after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2

 

Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial    

10 August 2021 - A previous efficacy trial found benefit from inhaled budesonide for COVID-19 in patients not admitted to hospital, but effectiveness in high-risk individuals is unknown

 

Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylactics         

9 August 2021 - We identify two potent antibodies, nCoVmab1 and nCoVmab2, targeting the SARS-CoV-2 spike protein receptor-binding domain (RBD) with high affinities from a naïve human phage-displayed Fab library. nCoVmab1 and nCoVmab2 neutralize authentic SARS-CoV-2 with picomolar and nanomolar IC50 values, respectively

 

A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency                                                                

8 August 2021 - The SARS-CoV-2 receptor angiotensin converting enzyme 2 (ACE2) was previously engineered into a high affinity tetravalent format (ACE2-Fc-TD) that is a potential decoy protein in SARS-CoV-2 infection.We report that this protein shows greatly enhanced binding to SARS-CoV-2 spike proteins of the SARS-CoV-2 variants of concern B.1.1.7

 

Potential therapeutic approaches for the early entry of SARS-CoV-2 by interrupting the interaction between the spike protein on SARS-CoV-2 and angiotensin-converting enzyme 2 (ACE2)                                                                                  

8 August 2021 - The virus spike protein (S protein) can recognize the angiotensin-converting enzyme 2 (ACE2) receptor on the host cell membrane and undergo a series of conformational changes, protease cleavage and membrane fusion to complete the virus entry, so S protein is an important target for vaccine and drug development

 

Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19

04 August 2021 - Subcutaneous REGEN-COV prevented symptomatic Covid-19 and asymptomatic SARS-CoV-2 infection in previously uninfected household contacts of infected persons. Among the participants who became infected, REGEN-COV reduced the duration of symptomatic disease and the duration of a high viral load

 

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19     

04 August 2021 - In noncritically ill patients with Covid-19, an initial strategy of therapeutic-dose anticoagulation with heparin increased the probability of survival to hospital discharge with reduced use of cardiovascular or respiratory organ support as compared with usual-care thromboprophylaxis

 

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19            

04 August 2021 - We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill patients with Covid-19

 

Anti-SARS-CoV-2 and anti-cytokine storm neutralizing antibody therapies against COVID-19: Update, challenges, and perspectives                       

3 August 2021 - Developing strategies to block this interaction has therefore been identified as a way to treat this infection

 

The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19                                                            

03 August 2021 - In mice sensitized to SARS-CoV-2 infection by transduction with human ACE2, intranasal nafamostat treatment prior to or shortly after SARS-CoV-2 infection significantly reduced weight loss and lung tissue titers

 

Elevated INR in a COVID-19 patient after concomitant administration of favipiravir and warfarin: A case report                                                       

02 August 2021 - Favipiravir and warfarin might have previously unidentified drug interactions that elevated the INR. Therefore, INR must be closely monitored when they are concomitantly administered in COVID-19 patients

 

S100A8 may govern hyper-inflammation in severe COVID-19                            

02 August 2021 - The underlying evidence includes accumulating clinical information that S100A8 is upregulated in severe forms of COVID-19, pathological similarities of the affected lungs between COVID-19 and S100A8-induced acute respiratory distress syndrome (ARDS) model

 

SARS-CoV-2 spike protein: pathogenesis, vaccines, and potential therapies   

02 August 2021 - The objectives of this study are to investigate the distinctive structural features of SARS-CoV-2 S protein, its essential role in pathogenesis, and its use in the development of potential therapies and vaccines

 

NSAIDs and COVID-19: A Systematic Review and Meta-analysis                        

02 August 2021 - Nonsteroidal anti-inflammatory drugs (NSAIDs) have been discouraged for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, fearing that they could increase the risk of infection or the severity of SARS-CoV-2

Remdesivir for treatment of COVID 19; review of the pharmacological properties, safety and clinical effectiveness                                                    

31 July 2021 - The purpose of the article is to review available preclinical, clinical, and post-marketing data to assess the safety and efficacy of remdesivir in the treatment of COVID-19 patients

 

Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2    

30 July 2021 - In the battle against COVID-19, drugs discovered in repurposing screens are of particular interest because these could be rapidly implemented as treatments

 

Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia

29 July 2021 - Among patients hospitalized with Covid-19 pneumonia, tofacitinib led to a lower risk of death or respiratory failure through day 28 than placebo

 

Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro                                                            

29 July 2021 - Inhibitors of 3CLpro activity are screened in enzyme assays before further development of the most promising leads

 

A Novel Therapeutic Peptide Blocks SARS-CoV-2 Spike Protein Binding with Host Cell ACE2 Receptor                                                                                      

29 July 2021 - A critical step in the crosstalk between the virus and the host cell is the binding of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to the peptidase domain of the angiotensin-converting enzyme 2 (ACE2) receptor present on the surface of host cells

 

Synthesis and Identification of Novel Potential Molecules Against COVID-19 Main Protease Through Structure-Guided Virtual Screening Approach  

29 July 2021 - The present study aims at predicting the antiviral activity of two novel compounds using in silico approaches that might become potential leads against SARS-CoV-2.

 

Topological network based drug repurposing for coronavirus 2019                      

29 July 2021 - The global effort started to identify the best drug compounds to treat COVID-19, but going through a series of clinical trials and our lack of information about the details of the virus’s performance has slowed down the time to reach this goal

 

Antiviral drugs for coronavirus disease 2019 (COVID-19): A systematic review with network meta-analysis                                                                             

29 July 2021 - To better inform clinical practice, we summarized the findings from randomized controlled trials (RCTs) of antivirals for COVID-19

 

Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine     

28 July 2021 - We show on a single epitope level that a stable and fully functional CD8+ T cell response is vigorously mobilized one week after bnt162b2 prime vaccination when circulating CD4+ T cells and neutralizing antibodies are still weakly detectable

 

Potential protective role of the anti-PD-1 blockade against SARS-CoV-2 infection          

28 July 2021 - The findings may demonstrate the hypothesis that a winning strategy to combat SARS-CoV-2 infection could be the restoration of exhausted T-cells

 

Abbreviated Profile of Drugs (APOD): modeling drug safety profiles to prioritize investigational COVID-19 treatments                              

28 July 2021 - The method was extensively tested for various unbiased datasets based on different criteria such as drugs recalled worldwide for failing to meet safety standards, organ-specific toxicities, cytochrome P450 inhibitors, and Food and Drug Administration (FDA) approved drugs with remarkable successes

 

In-silico study of peptide-protein interaction of antimicrobial peptides potentially targeting SARS and SARS-CoV-2 nucleocapsid protein                  

27 July 2021 - This study is an attempt to find a suitable therapy using antimicrobial peptides (AMPs) by identifying peptide-protein interaction of AMPs and nucleocapsid protein of SARS and SARS-CoV- 2

 

Inactivated SARS-CoV-2 vaccine does not influence the profile of prothrombotic antibody nor increase the risk of thrombosis in a prospective Chinese cohort

27 July 2021 - Inactivated SARS-CoV-2 vaccine does not influence the profile of antiphospholipid antibody and anti-PF4-heparin antibody nor increase the risk of thrombosis

 

The virological impacts of SARS-CoV-2 D614G mutation

21 July 2021 - The current prevalent D614G variant, with glycine substituted for aspartic acid at position 614 in the spike glycoprotein (S protein), is one of such variants that became the main circulating strain worldwide in a short period of time

 

Structural insights into the distinctive RNA recognition and therapeutic potentials of RIG-I-like receptors

21 July 2021 - RNA viruses, including the coronavirus, develop a unique strategy to evade the host immune response by interrupting the normal function of cytosolic retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs)

 

Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant

21 July 2021 - The B.1.617.2 (delta) variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19), has contributed to a surge in cases in India and has now been detected across the globe, including a notable increase in cases in the United Kingdom. The effectiveness of the BNT162b2 and ChAdOx1 nCoV-19 vaccines against this variant has been unclear

 

Antiviral Effect of Budesonide against SARS-CoV-2    

20 July 2021 - Our results are encouraging as they could indicate a multimodal mode of action of budesonide against SARS-CoV-2 and COVID-19, which could contribute to an improved clinical performance

 

Development of alveolar and airway cells from human iPS cells: toward SARS-CoV-2 research and drug toxicity testing

15 July 2021 - These data suggest that hiPSC-derived AT2 and club cells provide a useful in vitro model for drug development

 

Glycan Nanostructures of Human Coronaviruses

15 July 2021 - Glycans are one of the main structural components of all microbes and organismic structures, including viruses—playing multiple essential roles in virus infection and immunity

 

Combination of mesenchymal stem cells and nicorandil: an emerging therapeutic challenge against COVID-19 infection-induced multiple organ dysfunction

15 July 2021  - Emerging experimental reports have highlighted the beneficial effects of mesenchymal stem cell (MSC) administration against COVID-19.

 

Computational drug repurposing study of antiviral drugs against main protease, RNA polymerase, and spike proteins of SARS-CoV-2 using molecular docking method

15 July 2021  - In this study, the inhibitory potential of more than 50 antiviraldrugs on three important proteins of SARS-CoV-2, was investigated using the molecular docking method.

 

Intranasal gene therapy to prevent infection by SARS-CoV-2 variants

15 July 2021  - Here we present an approach for preventing clinical sequelae and the spread of SARS-CoV-2 variants.

 

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

14 July 2021 – Here, we comprehensively characterize escape, breadth, and potency across a panel of SARS-CoV-2 antibodies targeting the receptor-binding domain (RBD).

 

Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19

14 July 2021 - Patients with underlying medical conditions are at increased risk for severe coronavirus disease 2019 (Covid-19). Whereas vaccine-derived immunity develops over time, neutralizing monoclonal-antibody treatment provides immediate, passive immunity and may limit disease progression and complications.

 

Systems vaccinology of the BNT162b2 mRNA vaccine in humans

12 July 2021 - Here we used a systems vaccinology approach to comprehensively profile the innate and adaptive immune responses of 56 healthy volunteers vaccinated with the Pfizer-BioNTech mRNA vaccine.

 

Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice

10 July 2021 - Small-molecule antivirals like remdesivir (RDV) and biologics such as human monoclonal antibodies (mAbs) have demonstrated therapeutic efficacy against SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19)

 

Mapping the human genetic architecture of COVID-19

08 July 2021 - Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes.

 

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

08 July 2021 - Here, we isolated an infectious Delta strain from a traveller returning from India. We examined its sensitivity to monoclonal antibodies (mAbs) and to antibodies present in sera from COVID-19 convalescent individuals or vaccine recipients, in comparison to other viral strains.

 

Antibody epitopes in vaccine-induced immune thrombotic thrombocytopenia

07 July 2021 – The objective of this study was to determine the binding site on PF4 of antibodies from patients with VITT.

 

Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile

07 July 2021 - A countrywide mass vaccination campaign with the use of an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (CoronaVac) was conducted in Chile starting on February 2, 2021.

 

Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan

July 6, 2021 - To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting a total of 1,782 plasma samples from 869 convalescent plasma donors in Wuhan, China and test specific antibody responses

 

The molecular dynamics of possible inhibitors for SARS-CoV-2

July 6, 2021 - The novel coronavirus SARS-CoV-2, responsible for the present COVID-19 global pandemic, is known to bind to the angiotensin converting enzyme-2 (ACE2) receptor in human cells

 

Detection of significant antiviral drug effects on COVID-19 with reasonable sample sizes in randomized controlled trials: A modeling study

July 6, 2021 - Development of an effective antiviral drug for Coronavirus Disease 2019 (COVID-19) is a global health priority

 

In silico Screening of Natural Phytocompounds Towards Identification of Potential Lead Compounds to Treat COVID-19

05 July 2021 - Two proteins namely S-ACE2 and Mpro have been taken for the present study based on the higher resolution. SARS-CoV-2 contains a spike (S) protein that helps viral entry into the host cell and releases virus particles by attaching to a cell surface receptor called human angiotensin-converting enzyme 2 (ACE2) which facilitates viral transcription and replication

 

Post-anticoagulant D-dimer is a highly prognostic biomarker of COVID-19 mortality

July 5, 2021 - Clinical biomarkers that accurately predict mortality are needed for the effective management of patients with severe coronavirus disease 2019 (COVID-19) illness

 

In silico analysis of echinocandins binding to the main proteases of coronaviruses PEDV (3CLpro) and SARS-CoV-2 (Mpro)

July 1, 2021 - The porcine epidemic diarrhea virus (PEDV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are two highly pathogenic viruses causing tremendous damages to the swine and human populations, respectively

 

Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors

July 1, 2021 - The COVID-19 pandemic has clearly brought the healthcare systems worldwide to a breaking point, along with devastating socioeconomic consequences

 

CRISPR-Cas System: The Powerful Modulator of Accessory Genomes in Prokaryotes

June 30, 2021 - Being frequently exposed to foreign nucleic acids, bacteria and archaea have developed an ingenious adaptive defense system, called CRISPR-Cas

 

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

June 30, 2021 - Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, data are scarce on vaccine efficacy against variants of concern (VOC) in individuals above 80 years of age

 

Prevention and Attenuation of Covid-19 with the BNT162b2 and mRNA-1273 Vaccines

June 30, 2021 - Information is limited regarding the effectiveness of the two-dose messenger RNA (mRNA) vaccines BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna) in preventing infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in attenuating coronavirus disease 2019 (Covid-19) when administered in real-world conditions

 

Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine

June 30, 2021 - Early clinical data from studies of the NVX-CoV2373 vaccine (Novavax), a recombinant nanoparticle vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that contains the full-length spike glycoprotein of the prototype strain plus Matrix-M adjuvante

 

Prediction and identification of T cell epitopes of COVID-19 with balanced cytokine response for the development of peptide based vaccines

June 28, 2021 - Recent outbreak of 2019 novel Corona virus poses serious challenge for the global health system. In lieu of paucity of experimental data, tools and the very basic understanding of host immune responses against SARS-CoV-2, well thought effective measures are needed to control COVID-19 pandemic

 

SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses

June 28, 2021 - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA)-based vaccines are ~95% effective in preventing coronavirus disease 2019

 

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy children and adolescents: a double-blind, randomised, controlled, phase 1/2 clinical trial

June 28, 2021 - A vaccine against SARS-CoV-2 for children and adolescents will play an important role in curbing the COVID-19 pandemic

 

Nitazoxanide superiority to placebo to treat moderate COVID-19 – A Pilot prove of concept randomized double-blind clinical trial

June 26, 2021 - The absence of specific antivirals to treat COVID-19 leads to the repositioning of candidates’ drugs. Nitazoxanide (NTZ) has a broad antiviral effect

 

Effect of Tenofovir Disoproxil Fumarate and Emtricitabine on nasopharyngeal SARS-CoV-2 viral load burden amongst outpatients with COVID-19: A pilot, randomized, open-label phase 2 trial

June 26, 2021 - Tenofovir and emtricitabine interfere with the SARS CoV-2 ribonucleic acid (RNA)-dependent RNA polymerase (RdRp)

 

Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques

June 23, 2021 - The emergence of SARS-CoV-2 variants that partially evade neutralizing antibodies poses a threat to the efficacy of current COVID-19 vaccines

 

Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques

June 23, 2021 - The emergence of SARS-CoV-2 variants that partially evade neutralizing antibodies poses a threat to the efficacy of current COVID-19 vaccines1,2

 

TRP channels in COVID-19 disease: Potential targets for prevention and treatment

June 22, 2021 - Coronavirus disease 2019 [COVID-19] is a global health threat caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV2] that requires two proteins for entry: angiotensin-converting enzyme 2 [ACE2] and trans-membrane protease serine 2 [TMPRSS2]

 

In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains

June 21, 2021 - Rapidly-emerging variants jeopardize antibody-based countermeasures against SARS-CoV-2

 

Molecular insight into the genomic variation of SARS-CoV-2 strains from current outbreak

June 18 , 2021 - Coronavirus disease 2019 (COVID-19) is the newly emerging viral disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

 

Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia

June 16, 2021 - The efficacy and safety of tofacitinib, a Janus kinase inhibitor, in patients who are hospitalized with coronavirus disease 2019 (Covid-19) pneumonia are unclear

 

Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection

June 14, 2021 - Over one year after its inception, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several excellent vaccines

 

Multiplexed and High-Throughput Label-Free Detection of RNA/Spike Protein/IgG/IgM Biomarkers of SARS-CoV-2 Infection Utilizing Nanoplasmonic Biosensors

June 14, 2021 - To tackle the COVID-19 outbreak, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is an unmet need for highly accurate diagnostic tests at all stages of infection with rapid results and high specificity

 

Molecular biology of the SARs-CoV-2 spike protein: A review of current knowledge

June 14, 2021 - The global coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to an unprecedented worldwide public health emergency

 

Understanding individual SARS-CoV-2 proteins for targeted drug development against COVID-19

June 14, 2021 - SARS-CoV-2 causes the COVID-19 pandemic responsible for millions of deaths globally

 

Dynamic Profiling of β-Coronavirus 3CL Mpro Protease Ligand-Binding Sites

June 14, 2021 - β-coronavirus (CoVs) alone has been responsible for three major global outbreaks in the 21st century

 

A long-term perspective on immunity to COVID

June 14, 2021 - Determining the duration of protective immunity to infection by SARS-CoV-2 is crucial for understanding and predicting the course of the COVID-19 pandemic. Clinical studies now indicate that immunity will be long-lasting

 

Interferon therapy in patients with SARS, MERS, and COVID-19: A systematic review and meta-analysis of clinical studies

June 12, 2021 - Concern regarding coronavirus (CoV) outbreaks has stayed relevant to global health in the last decades

 

Renin–Angiotensin–Aldosterone System Inhibitors and SARS-CoV-2 Infection: An Analysis from the Veteran's Affairs Healthcare System: Sandhu. ACEI, ARB, and Association with COVID

June 12, 2021 - Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) are known to impact the functional receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

 

Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination

June 10, 2021 - The mainstay of control of the coronavirus disease 2019 (Covid-19) pandemic is vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

 

SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2

June 08, 2021 - In this study we profiled vaccine-induced polyclonal antibodies as well as plasmablast-derived mAbs from individuals who received SARS-CoV-2 spike mRNA vaccine

 

Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species

June 08, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to emerge during the global pandemic and may facilitate escape from current antibody therapies and vaccine protection

 

Inhibitory Potential of Phytochemicals on Interleukin-6-Mediated T-Cell Reduction in COVID-19 Patients: A Computational Approach

June 08, 2021 - A recent COVID-19 pandemic has resulted in a large death toll rate globally and even no cure or vaccine has been successfully employed to combat this disease

 

Convalescent Plasma Therapy for COVID-19: A Graphical Mosaic of the Worldwide Evidence

June 07, 2021 - Convalescent plasma has been used worldwide to treat patients hospitalized with coronavirus disease 2019 (COVID-19) and prevent disease progression

 

Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants

June 07, 2021 -  Since the start of the COVID-19 pandemic, SARS-CoV-2 has caused millions of deaths worldwide

 

Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants

June 03, 2021 -  Resistance represents a major challenge for antibody-based therapy for coronavirus disease 2019 (COVID-19)^1–4

 

Therapeutic use of specific tumour necrosis factor inhibitors in inflammatory diseases including COVID-19

May 28, 2021- Coronavirus disease 2019 (COVID-19) has caused significant devastation globally

 

Favipiravir for the treatment of patients with COVID-19: a systematic review and meta-analysis

May 27, 2021- Favipiravir possesses high utility for treating patients with COVID-19. However, research examining the efficacy and safety of favipiravir for patients with COVID-19 is limited

 

Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents

May 27, 2021- Until very recently, vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had not been authorized for emergency use in persons younger than 16 years of age

BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

May 27, 2021 - BNT162b2, a lipid nanoparticle (LNP) formulated nucleoside-modified messenger RNA (mRNA) that encodes the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (S) stabilized in the prefusion conformation, has demonstrated 95% efficacy in preventing coronavirus disease-19 (COVID-19)

 

Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection

May 27, 2021 - In a randomized clinical trial of 86 hospitalized COVID-19 patients comparing standard care to treatment with 300mL convalescent plasma containing high titers of neutralizing SARS-CoV-2 antibodies, no overall clinical benefit was observed

 

The efficacy and safety of Favipiravir in treatment of COVID-19: a systematic review and meta-analysis of clinical trials

May 26, 2021 - The novel coronavirus outbreak began in late December 2019 and rapidly spread worldwide, critically impacting public health systems

 

Novel human neutralizing mAbs specific for Spike-RBD of SARS-CoV-2

May 26, 2021 - Among the therapies against the pandemic SARS-CoV-2 virus, monoclonal Antibodies (mAbs) targeting the Spike glycoprotein represent good candidates to interfere in the Spike/ACE2 interaction, preventing virus cell entry

 

Quinoline and Quinazoline Derivatives Inhibit Viral RNA Synthesis by SARS-CoV-2 RdRp

May 26, 2021 - Coronavirus disease 2019 (COVID-19) is a fatal respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

 

Reckoning γ-Glutamyl-S-allylcysteine as a potential Main protease (Mpro) inhibitor of novel SARS-CoV-2 virus identified using docking and molecular dynamics simulation

May 26, 2021 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2 or COVID-19), outbreak was first reported in December 2019 in the Wuhan, China

 

Association of Intravenous Bamlanivimab Use with Reduced Hospitalization, Intensive Care Unit Admission, and Mortality in Patients with Mild to Moderate COVID-19

May 25, 2021- Clinical data to support the use of bamlanivimab for the treatment of outpatients with mild to moderate coronavirus disease-19 (COVID-19) is needed

 

Efficacy and safety of sofosbuvir/velpatasvir versus the standard of care in adults hospitalized with COVID-19: a single-centre, randomized controlled trial

May 25, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic

 

Benefits of treatment with favipiravir in hospitalized patients for COVID-19: a retrospective observational case–control study

May 25, 2021 - Although more than a year past since COVID-19 was defined, there is no specific treatment yet.

 

Siltuximab downregulates interleukin-8 and pentraxin 3 to improve ventilatory status and survival in severe COVID-19

May 24, 2021 - Severe coronavirus disease 2019 (COVID-19) is characterized by interstitial pneumonia/acute respiratory distress syndrome and hyperinflammation, with elevated levels of proinflammatory cytokines, such as interleukin-6 (IL-6), associated with mortality and patients requiring ventilator suppor

 

Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication

May 24, 2021 - Treatment options for COVID-19 remain limited, especially during the early or asymptomatic phase. Here, we report a novel SARS-CoV-2 viral replication mechanism mediated by interactions between ACE2 and the epigenetic eraser enzyme LSD1, and its interplay with the nuclear shuttling importin pathway

 

Monoclonal Antibodies for Early Treatment of COVID-19 in a World of Evolving SARS-CoV-2 Mutations and Variants

23/mai - Monoclonal antibodies targeting the receptor binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 spike protein are important outpatient treatment options in coronavirus disease 2019 to mitigate progression of disease and prevent hospitalization

 

Single dose of BNT162b2 mRNA vaccine against SARS-CoV-2 induces high frequency of neutralising antibody and polyfunctional T-cell responses in patients with myeloproliferative neoplasms

May 22, 2021 - Encouraging results have been observed from initial studies evaluating vaccines targeting the novel beta coronavirus which causes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

 

Existing Drugs Considered as Promising in COVID-19 Therapy

May 21, 2021- COVID-19 is a respiratory disease caused by newly discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease at first was identified in the city of Wuhan, China in December 2019

 

Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening

May 19, 2021 - Although the main cellular target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is thought to be alveolar cells, the absence of their tractable culture system precludes the development of a clinically relevant SARS-CoV-2 infection model

 

Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate

May 19, 2021- In late December 2019, a novel coronavirus, namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), escaped the animal–human interface and emerged as an ongoing global pandemic with severe flu-like illness, commonly known as coronavirus disease 2019 (COVID-19)

 

Aptamer BC 007’s Affinity to Specific and Less-Specific Anti-SARS-CoV-2 Neutralizing Antibodies

May 18, 2021- COVID-19 is a pandemic respiratory disease that is caused by the highly infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Anti-SARS-CoV-2 antibodies are essential weapons that a patient with COVID-19 has to combat the disease

 

Therapeutic Potential of Exploiting Autophagy Cascade Against Coronavirus Infection

May 14, 2021- Since its emergence in December 2019 in Wuhan, China, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) created a worldwide pandemic of coronavirus disease (COVID-19) with nearly 136 million cases and approximately 3 million deaths

 

Interferon‐α‐2b Aerosol Inhalation is Associated with Improved Clinical Outcomes in Patients with Coronavirus Disease‐2019

May 13, 2021 - Type 1 interferon (IFN) is used to treat patients with coronavirus disease‐2019 (COVID‐19) but robust supporting evidence is lacking

 

Problems associated with antiviral drugs and vaccines development for COVID-19: approach to intervention using expression vectors via GPI anchor

May 13, 2021 - The outbreak of a novel coronavirus responsible for the severe acquired respiratory syndrome: SARS-CoV-2, also known as coronavirus disease 2019: COVID-19, represents a pandemic threat that has been declared a public health emergency of international concern

 

Aerosolized nanoliposomal carrier of remdesivir: an effective alternative for COVID-19 treatment in vitro

May 13, 2021 - Remdesivir is one of the first drugs approved for the treatment of coronavirus disease 2019. Currently, it is administered via an injection into the bloodstream

 

A phase I study of high dose camostat mesylate in healthy adults provides a rationale to repurpose the TMPRSS2 inhibitor for the treatment of COVID‐19

May 13, 2021 - Camostat mesylate, an oral serine protease inhibitor, is used to treat chronic pancreatitis and reflux esophagitis

 

Antibody responses to single‐dose SARS‐CoV‐2 vaccination in patients receiving immunomodulators for immune‐mediated inflammatory disease

May 12, 2021 - There are few data on whether immunomodulator therapy attenuates humoral response to vaccines for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)

 

The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry

May 12, 2021 - Since the outbreak of coronavirus disease 2019 (COVID-19), it has become a global pandemic

 

SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis

May 12, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing coronavirus disease 19 pandemic

 

Candesartan as a tentative treatment for COVID-19: a prospective non-randomized open-label study

May 11, 2021 - Candesartan as a tentative treatment for COVID-19: a prospective non-randomized open-label study

 

Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses

May 10, 2021 - Betacoronaviruses (betaCoVs) caused the severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS) outbreaks, and the SARS-CoV-2 pandemic

 

Clinical Impact of the Early Use of Monoclonal Antibody LY-CoV555 (Bamlanivimab) on Mortality and Hospitalization Among Elderly Nursing Home Patients: A Multicenter Retrospective Study

May 10, 2021 - Coronavirus disease 2019 (COVID-19) outbreaks are frequent occurrences in nursing homes and long-term care facilities (LTCFs), resulting in subsequent hospitalization and death

 

siRNA Therapeutics for the Therapy of COVID-19 and Other Coronaviruses

May 04, 2021 - The ongoing pandemic of global concern has killed about three million humans and affected around 151 million people worldwide, as of April 30, 2021

 

Determinants of IgG antibodies kinetics after severe and critical COVID‐19

May 04, 2021 - The kinetics of IgG antibodies after COVID‐19 remain poorly understood. We investigated factors influencing severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) IgG antibody levels and time to seronegativation during the follow‐up of severe and critically ill patients.

 

Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial

May 04, 2021 - Convalescent plasma has been used for numerous viral diseases including influenza, severe acute respiratory syndrome, Middle East respiratory syndrome and Ebola virus; however, evidence to support its use is weak.

 

How COVID-19 has fundamentally changed clinical research in global health

May 01, 2021 - COVID-19 has had negative repercussions on the entire global population

 

Inhibitors of Protein Glycosylation Are Active against the Coronavirus Severe Acute Respiratory Syndrome Coronavirus SARS-CoV-2

April 30, 2021 - Repurposing clinically available drugs to treat the new coronavirus disease 2019 (COVID-19) is an urgent need in the course of the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) pandemic, as very few treatment options are available.

 

Dolutegravir Plus Lamivudine Two-Drug Regimen: Safety, Efficacy and Diagnostic Considerations for Its Use in Real-Life Clinical Practice—A Refined Approach in the COVID-19 Era

April 29, 2021 - The diagnostic and therapeutic management of the Coronavirus Disease 2019 (COVID-19) pandemic in the HIV population brought some known criticalities (and opportunities) to the forefront, for both those who are facing their first therapeutic line today, and for those already well viro-suppressed.

 

Type I Interferon-Mediated Regulation of Antiviral Capabilities of Neutrophils

April 29, 2021 - Interferons (IFNs) are induced by viruses and are the main regulators of the host antiviral response.

 

Antiviral Properties of the NSAID Drug Naproxen Targeting the Nucleoprotein of SARS-CoV-2 Coronavirus

April 29, 2021 - There is an urgent need for specific antiviral treatments directed against SARS-CoV-2 to prevent the most severe forms of COVID-19. By drug repurposing, affordable therapeutics could be supplied worldwide in the present pandemic context.

Genome-Wide B Cell, CD4+, and CD8+ T Cell Epitopes That Are Highly Conserved between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Targets for Preemptive Pan-Coronavirus Vaccines

April 28, 2021 - Over the last two decades, there have been three deadly human outbreaks of coronaviruses (CoVs) caused by SARS-CoV, MERS-CoV, and SARS-CoV-2, which has caused the current COVID-19 global pandemic

 

Inhibitors of coronavirus 3CL proteases protect cells from protease-mediated cytotoxicity

April 28, 2021 - We describe a mammalian cell-based assay to identify coronavirus 3CL protease (3CLpro) inhibitors

 

Cytokine storm modulation in COVID-19: a proposed role for vitamin D and DPP-4 inhibitor combination therapy (VIDPP-4i)

April 28, 2021 - A dysregulated immune response characterized by the hyperproduction of several pro-inflammatory cytokines (a.k.a. ‘cytokine storm’) plays a central role in the pathophysiology of severe coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

 

A computational approach to aid clinicians in selecting anti-viral drugs for COVID-19 trials

April 27, 2021 - The year 2020 witnessed a heavy death toll due to COVID-19, calling for a global emergency

 

SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy

April 27, 2021 - Reinfection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been documented, raising public health concerns

 

Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study

April 27, 2021 - The Pfizer-BioNTech (BNT162b2) and the Oxford-AstraZeneca (ChAdOx1 nCoV-19) COVID-19 vaccines have shown excellent safety and efficacy in phase 3 trials

 

Drug-utilisation profiles and COVID-19

April 26, 2021 - Coronavirus disease 2019 (COVID-19) has substantially challenged healthcare systems worldwide

 

Analysis of IgM, IgA, and IgG isotype antibodies Directed against SARS-CoV-2 spike glycoprotein and ORF8 in the course of COVID-19

April 26, 2021 - Immunoassays are a standard diagnostic tool that assesses immunity in severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection

 

An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19

April 24, 2021 - The global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019 (COVID-19)

 

Biomolecular interactions with nanoparticles: Applications for COVID-19

April 23, 2021 - Nanoparticles are small particles sized 1 to 100 nm, which have a large surface to volume ratio, allowing efficient adsorption of drugs, proteins and other chemical compounds

 

COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study

April 23, 2021 - BNT162b2 mRNA and ChAdOx1 nCOV-19 adenoviral vector vaccines have been rapidly rolled out in the UK from December, 2020

 

Triazole, imidazole, and thiazole-based compounds as potential agents against coronavirus

April 22, 2021 - The expansion of the novel coronavirus known as SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), COVID-19 (coronavirus disease 2019), or 2019-nCoV (2019 novel coronavirus) is a global concern over its pandemic potential

 

Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19

April 21, 2021 - Coronavirus disease 2019 (COVID-19) is especially severe in aged populations1

 

Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons

April 21, 2021 - Many pregnant persons in the United States are receiving messenger RNA (mRNA) coronavirus disease 2019 (Covid-19) vaccines, but data are limited on their safety in pregnancy

 

Vaccine Breakthrough Infections with SARS-CoV-2 Variants

April 21, 2021 - Emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of clinical concern

 

Roles of Type I and III Interferons in COVID-19

April 20, 2021 - Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

 

A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19

April 19, 2021 - Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in humans

 

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

April 19, 2021 - The development of a portfolio of COVID-19 vaccines to vaccinate the global population remains an urgent public health imperative1

 

High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors

April 17, 2021 - A new coronavirus (SARS-CoV-2) has been identified as the etiologic agent for the COVID-19 outbreak

 

A combined assay for quantifying remdesivir and its metabolite, along with dexamethasone, in serum

April 17, 2021 - As global confirmed cases and deaths from coronavirus disease 2019 (COVID-19) surpass 100 and 2.2 million, respectively, quantifying the effects of the widespread treatment of remdesivir (GS-5734, Veklury) and the steroid dexamethasone is becoming increasingly important

 

Methylene blue photochemical treatment as a reliable SARS-CoV-2 plasma virus inactivation method for blood safety and convalescent plasma therapy for COVID-19

April 16, 2021 - In 2020, a new coronavirus, SARS-CoV-2, quickly spread worldwide within a few months. Although coronaviruses typically infect the upper or lower respiratory tract, the virus RNA can be detected in plasma

 

Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination

April 16, 2021 - The mainstay of control of the coronavirus disease 2019 (Covid-19) pandemic is vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

 

Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery

April 15, 2021 - Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019 (COVID-19) are particularly important, as there is still no effective strategy for severe COVID-19 patient treatment

 

Current update on SARS-CoV-2 vaccine development with a special emphasis on gene therapy viral vector design and construction for vaccination

April 15, 2021 - Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease (COVID-19) caused by the novel coronavirus SARS-CoV-2

 

Probable Interaction Between Warfarin and the Combination of Remdesivir With Dexamethasone for Coronavirus Disease 2019 (COVID-19) Treatment: A 2 Case Report

April 15, 2021 - To describe a potential drug interaction between warfarin and the combination of remdesivir with dexamethasone

 

Identifying clinical and biochemical phenotypes in acute respiratory distress syndrome secondary to coronavirus disease-2019

April 15, 2021 - Acute respiratory distress syndrome (ARDS) secondary to coronavirus disease-2019 (COVID-19) is characterized by substantial heterogeneity in clinical, biochemical, and physiological characteristics

 

Novel 1,2,3-Triazole Derivatives as Potential Inhibitors against Covid-19 Main Protease: Synthesis, Characterization, Molecular Docking and DFT Studies

April 14, 2021 -The highly contagious nature of Covid-19 attracted us to this challenging area of research, mainly because the disease is spreading very fast and until now, no effective method of a safe treatment or a vaccine is developed

 

Initiation of psychotropic medication in hospitalized patients with COVID‐19: Association with clinical and biological characteristics

April 14, 2021 - Inpatients with coronavirus disease 2019 (COVID‐19) show a high rate of neuropsychiatric manifestations, possibly related to a higher risk of serious illness or death

 

COVID-19 pathophysiology and pharmacology: What do we know and how did Canadians respond? A review of Health Canada authorized clinical vaccine and drug trials

April 14, 2021 - Coronavirus disease 2019 (COVID-19) has resulted in the death of over 18000 Canadians and has impacted the lives of all Canadians

 

Multicentre randomised double-blinded placebo-controlled trial of favipiravir in adults with mild COVID-19

April 14, 2021 - A novel coronavirus, designated SARS-CoV-2, caused an international outbreak of a respiratory illness, termed COVID-19 in December 2019

 

PEGylated nanoparticle albumin-bound steroidal ginsenoside derivatives ameliorate SARS-CoV-2-mediated hyper-inflammatory responses

April 14, 2021 - The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on a global scale urges prompt and effective countermeasures

 

The role of CD4+FoxP3+ regulatory T cells in the immunopathogenesis of COVID-19: implications for treatment

April 10, 2021 - The severe cases of Coronavirus Disease 2019 (COVID-19) frequently exhibit excessive inflammatory responses, acute respiratory distress syndrome (ARDS), coagulopathy, and organ damage

 

Development and application of therapeutic antibodies against COVID-19

April 10, 2021 - The pandemic of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome 2 coronavirus (SARS-CoV-2) continues to be a global health crisis

 

Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination

April 9, 2021 - Several cases of unusual thrombotic events and thrombocytopenia have developed after vaccination with the recombinant adenoviral vector encoding the spike protein antigen of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (ChAdOx1 nCov-19, AstraZeneca)

 

How Are Emerging Data Translated Into Clinical Practice? A Mixed Methods Investigation of Coronavirus Disease 2019 Institutional Treatment Protocols

April 07, 2021 - Early in the coronavirus disease 2019 (COVID-19) pandemic, there was minimal data to guide treatment, and we lacked understanding of how clinicians translated this limited evidence base for potential therapeutics to bedside care

 

Cytotoxic T-lymphocyte elicited vaccine against SARS-CoV-2 employing immunoinformatics framework

April 07, 2021 -  Development of effective counteragents against the novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, requires clear insights and information for understanding the immune responses associated with it

 

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation

April 07, 2021 -  Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical manifestations affecting the lungs, liver, kidneys and gut

 

Drugs that inhibit TMEM16 proteins block SARS-CoV-2 Spike-induced syncytia

April 07, 2021 -  COVID-19 is a disease with unique characteristics including lung thrombosis1, frequent diarrhoea2, abnormal activation of the inflammatory response3 and rapid deterioration of lung function consistent with alveolar oedema4

 

Convalescent Plasma for the Prevention and Treatment of COVID-19: A Systematic Review and Quantitative Analysis

April 07, 2021 -  The COVID-19 pandemic, caused by a novel coronavirus termed SARS-CoV-2, has spread quickly worldwide

 

Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 infection in vitro

April 06, 2021 - The SARS‐COV‐2 pandemic and the global spread of coronavirus disease 2019 (COVID‐19) urgently call for efficient and safe antiviral treatment strategies

 

A randomized, double-blind, placebo-controlled phase 1 trial of inhaled and intranasal niclosamide: A broad spectrum antiviral candidate for treatment of COVID-19

April 06, 2021 - Coronavirus disease 19 (COVID-19) is spreading globally and treatment options remain limited

 

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells

April 05, 2021 - COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment, and one important factor to consider is oxygen tension, in which hypoxia inducible factor (HIF) regulates transcriptional responses to hypoxia

 

COVID-19 and Pembrolizumab-Induced Secondary Hemophagocytic Lymphohistiocytosis: a Case Report

April 02, 2021 - Our case highlights SARS-CoV-2 and pembrolizumab as trigger of secondary hemophagocytic lymphohistiocytosis

 

Design and Identification of Novel Annomontine Analogues Against SARS-CoV-2: An In-Silico Approach

April 02, 2021 - COVID-19 has currently emerged as the major global pandemic affecting the lives of people across the globe

 

Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19: A Review

March 30, 2021 - Among the multiple uncertainties surrounding the novel coronavirus disease (COVID-19) pandemic, a research letter published in The Lancet implicated drugs that antagonize the renin-angiotensin-aldosterone system (RAAS) in an unfavorable prognosis of COVID-19

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial

March 30, 2021 - A new variant of SARS-CoV-2, B.1.1.7, emerged as the dominant cause of COVID-19 disease in the UK from November, 2020

 

A Recombinant Fragment of Human Surfactant Protein D Binds Spike Protein and Inhibits Infectivity and Replication of SARS-CoV-2 in Clinical Samples

March 30, 2021 - COVID -19 is an acute infectious disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

 

Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor

March 30, 2021 - Remdesivir (RDV, Veklury®) is a once-daily, nucleoside ribonucleic acid polymerase inhibitor of severe acute respiratory syndrome coronavirus 2 replication

 

Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial

March 30, 2021 - Type III interferons have been touted as promising therapeutics in outpatients with coronavirus disease 2019 (COVID-19)

 

SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself

March 30, 2021 - The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-2

 

Precision therapeutic targets for COVID-19

March 29, 2021 - Beginning in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as a novel pathogen that causes coronavirus disease 2019 (COVID-19)

 

The potential of miRNA-based therapeutics in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection: a review

March 24, 2021 - Since the World Health Organization (WHO) declared COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as a pandemic in March 2020, and more than 117 million people worldwide have been confirmed to have been infected

 

Repurposing Quinoline and Artemisinin Antimalarials as Therapeutics for SARS-CoV-2: Rationale and Implications

March 22, 2021 - The coronavirus disease-2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than 116 million individuals globally and resulted in over 2.5 million deaths since the first report in December 2019

 

Comparison of clinical manifestations, pre-existing comorbidities, complications and treatment modalities in severe and non-severe COVID-19 patients: A systemic review and meta-analysis

March 22, 2021 - The global pandemic of novel coronavirus disease 2019 (COVID-19) has become an emergency of major international concern

 

A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2

March 22, 2021 - The scientific community is focused on developing antiviral therapies to mitigate the impacts of the ongoing novel coronavirus disease 2019 (COVID-19) outbreak

Computational Mutagenesis at the SARS-CoV-2 Spike Protein/Angiotensin-Converting Enzyme 2 Binding Interface: Comparison with Experimental Evidence

March 18, 2021 - The coronavirus disease-2019 (COVID-19) pandemic, caused by the pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), started in China during late 2019 and swiftly spread worldwide

 

COVID-19: pathogenesis, advances in treatment and vaccine development and environmental impact—an updated review

March 18, 2021 - Diseases negatively impact the environment, causing many health risks and the spread of pollution and hazards

 

Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication

March 17, 2021 - The current pandemic is caused by a newly discovered coronavirus, severe-acute-respiratory-syndrome-related coronavirus 2 (SARS-CoV-2)

 

Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trial

March 17, 2021 - In patients with COVID-19, granulocyte-macrophage colony stimulating factor (GM-CSF) might be a mediator of the hyperactive inflammatory response associated with respiratory failure and death

 

Antiviral Efficacy of Pralatrexate against SARS-CoV-2

March 17, 2021 - Novel coronavirus (SARS-CoV-2) has caused more than 100 million confirmed cases of human infectious disease (COVID-19) since December 2019 to paralyze our global community

 

Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant

March 16, 2021 - Assessment of the safety and efficacy of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different populations is essential, as is investigation of the efficacy of the vaccines against emerging SARS-CoV-2 variants of concern, including the B.1.351 (501Y.V2) variant first identified in South Africa

 

Plasma IL-6 levels following corticosteroid therapy as an indicator of ICU length of stay in critically ill COVID-19 patients

March 15, 2021 - Intensive care unit (ICU) admissions and mortality in severe COVID-19 patients are driven by “cytokine storms” and acute respiratory distress syndrome (ARDS)

 

Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications

March 12, 2021 - Cytokine release syndrome (CRS) is a major cause of the multi-organ injury and fatal outcome induced by SARS-CoV-2 infection in severe COVID-19 patients

 

Discovery of Clioquinol and analogues as novel inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 infection, ACE2 and ACE2 - Spike protein interaction in vitro

March 11, 2021 - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease 2019 (COVID-19), has resulted in an ongoing pandemic

 

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

March 11, 2021 - SARS-CoV-2 transmission is uncontrolled in many parts of the world, compounded in some areas by higher transmission potential of the B1.1.7 variant1 now reported in 94 countries

 

Structure, Dynamics, Receptor Binding, and Antibody Binding of the Fully Glycosylated Full-Length SARS-CoV-2 Spike Protein in a Viral Membrane

March 10, 2021 - The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediates host cell entry by binding to angiotensin-converting enzyme 2 (ACE2) and is considered the major target for drug and vaccine development

 

A Dual Target-Directed Single Domain-Based Fusion Protein Against Interleukin-6 Receptor Decelerate Experimental Arthritis Progression Via Modulating JNK Expression

March 10, 2021 - The currently used anti-cytokine therapeutic antibodies cannot selectively neutralize pathogenic cytokine signalling that cause collateral damage to protective signalling cascades

 
Overexpression of angiotensin-converting enzyme 2 by renin-angiotensin system inhibitors. Truth or myth? A systematic review of animal studies

March 10, 2021 - Angiotensin-converting enzyme 2 (ACE2) protects against organ damage in hypertension and cardiovascular diseases by counter regulating the renin-angiotensin system (RAS)

 

Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2

March 9, 2021 - Up to date, effective antivirals have not been widely available for treating COVID-19

 

Evaluation of the safety and efficacy of XAV-19 in patients with COVID-19-induced moderate pneumonia: study protocol for a randomized, double-blinded, placebo-controlled phase 2 (2a and 2b) trial

March 9, 2021 - Early inhibition of entry and replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a very promising therapeutic approach

 

Broad-Spectrum Anti-coronavirus Vaccines and Therapeutics to Combat the Current COVID-19 Pandemic and Future Coronavirus Disease Outbreaks

March 9, 2021 - While the COVID-19 pandemic caused by SARS-CoV-2 is continuing, it may become worse in the coming winter months with a high potential for the emergence and spread of escape variants of SARS-CoV-2

 

Ribavirin shows antiviral activity against SARS-CoV-2 and downregulates the activity of TMPRSS2 and the expression of ACE2 In Vitro

March 9, 2021 - Ribavirin is a guanosine analog and has a broad-spectrum antiviral activity against RNA viroses

 

Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection

March 08, 2021 - Synthetic ssDNA aptamers containing a conserved sequence motif that specifically targets the receptor-binding domain (RBD) of the SARS-CoV-2 spike have the capacity to neutralize the virus and prevent host cell infection in vitro, suggesting a new therapeutic approach to treat COVID-19

 

Temporal dynamics of the host molecular responses underlying severe COVID-19 progression and disease resolution

March 07, 2021 - The coronavirus disease-19 (COVID-19) pandemic has cost lives and economic hardships globally

 

Contribution of STAT3 to the pathogenesis of COVID-19

March 7, 2021 - Hyper-inflammatory responses, lymphopenia, unbalanced immune responses, cytokine storm, large viral replication and massive cell death play fundamental roles in the pathogenesis of COVID-19

 

Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics

March 4, 2021 - The COVID-19 agent, SARS-CoV-2, is conspecific with SARS-CoV, the causal agent of the severe acute respiratory syndrome epidemic in 2002–03

 

Tocilizumab plus standard care versus standard care in patients in India with moderate to severe COVID-19-associated cytokine release syndrome (COVINTOC): an open-label, multicentre, randomised, controlled, phase 3 trial

March 4, 2021 - Global randomised controlled trials of the anti-IL-6 receptor antibody tocilizumab in patients admitted to hospital with COVID-19 have shown conflicting results but potential decreases in time to discharge and burden on intensive care

 

Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial

March 4, 2021 - Elevated proinflammatory cytokines are associated with greater COVID-19 severity

 

Clinical evidence of an interferon–glucocorticoid therapeutic synergy in COVID-19

March 3, 2021 - Synthetic glucocorticoid dexamethasone is the first trial-proven drug that reduces COVID-19 mortality by suppressing immune system

 

Study on the promotion of lymphocytes in patients with COVID-19 by broad-spectrum chemokine receptor inhibitor vMIP-II and its Mechanism of signal transmission in vitro

March 2, 2021 - COVID-19 cases showed a significant decrease in the number of peripheral CD4+ and CD8+ T cells accompanied by overactivation of cells

 

Design, Synthesis and Biological Evaluation of 2-Aminoquinazolin-4(3H)-one Derivatives as Potential SARS-CoV-2 and MERS-CoV Treatments

March 2, 2021 - Despite the rising threat of fatal coronaviruses, there are no general proven effective antivirals to treat them

 

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

March 1, 2021 - SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells

 

Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection

February 25, 2021 - Hyperinflammatory response caused by infections such as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) increases organ failure, intensive care unit admission, and mortality

 

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

February 24, 2021 - As mass vaccination campaigns against coronavirus disease 2019 (Covid-19) commence worldwide, vaccine effectiveness needs to be assessed for a range of outcomes across diverse populations in a noncontrolled setting

 

Akt‐independent effects of triciribine on ACE2 expression in human lung epithelial cells: Potential benefits in restricting SARS‐CoV2 infection

February 24, 2021 - The severe acute respiratory syndrome coronavirus 2 that causes coronavirus disease 2019 (COVID‐19) binds to the angiotensin‐converting enzyme 2 (ACE2) to gain cellular entry

 

Insights into SARS-CoV-2 evolution, potential antivirals, and vaccines

February 22 , 2021 - SARS-CoV-2 is a novel coronavirus, spread among humans, and to date, more than 100 million of laboratory-confirmed cases have been reported worldwide

 

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

February 19, 2021 - The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for emergency use by the UK regulatory authority, Medicines and Healthcare products Regulatory Agency, with a regimen of two standard doses given with an interval of 4–12 weeks

 

Evaluation of drug repositioning by molecular docking of pharmaceutical resources available in the Brazilian healthcare system against SARS-CoV-2

February 19, 2021 - In 2020 SARS-CoV-2 reached pandemic status, reaching Brazil in mid-February. As of now, no specific drugs for treating the disease are available

 

Efficacy and harms of convalescent plasma for treatment of hospitalized COVID-19 patients: a systematic review and meta-analysis           

18 February 2021 - In comparison to SOC or placebo + SOC, CP did not reduce all-cause mortality in RCTs of hospitalized COVID-19 patients

 

Maintaining Safety with SARS-CoV-2 Vaccines

February 18, 2021 - To date, the development of mRNA vaccines for the prevention of infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a success story, with no serious concerns identified in the ongoing phase 3 clinical trials

 

The Evidence for High-Titer Convalescent Plasma in SARS-CoV-2

February 18, 2021 - Convalescent plasma therapy has been used successfully in the past to treat respiratory infections

 

Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

February 18, 2021 - Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive

 

A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia

February 18, 2021 - Convalescent plasma is frequently administered to patients with Covid-19 and has been reported, largely on the basis of observational data, to improve clinical outcomes

 

Carvacrol, a Plant Metabolite Targeting Viral Protease (M pro) and ACE2 in Host Cells Can Be a Possible Candidate for COVID-19

February 16, 2021 - The recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started in December 2019, resulting in the coronavirus disease-19 (COVID-19) pandemic

 

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

February 12, 2021 - SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism of action in vivo is incompletely understood

 

Challenges in ensuring global access to COVID-19 vaccines: production, affordability, allocation, and deployment

February 12, 2021 - The COVID-19 pandemic is unlikely to end until there is global roll-out of vaccines that protect against severe disease and preferably drive herd immunity

 

Antithrombotic and Anti-Inflammatory Effects of Fondaparinux and Enoxaparin in Hospitalized COVID-19 Patients: The FONDENOXAVID Study

February 11, 2021 - Our aim was to compare clinical characteristics, prophylactic treatment, markers of inflammation, and thrombotic outcomes in inpatients positive for SARS-CoV2 during hospitalization associated with thromboprophylaxis with enoxaparin (40 mg or 60 mg once daily) or fondaparinux (2.5 mg once daily)

 

Current evidence for COVID-19 therapies: a systematic literature review

February 10, 2021 - Effective therapeutic interventions for the treatment and prevention of coronavirus disease 2019 (COVID-19) are urgently needed

 

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

February 10, 2021 - Here we report on the antibody and memory B cell responses in a cohort of 20 volunteers who received either the Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) vaccines1–4

 

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

February 9, 2021 - All known recently emerged human coronaviruses probably originated in bats¹

 

Altered gut microbial metabolites could mediate the effects of risk factors in Covid-19

8 February 2021 - The preconditioned immune dysregulation enables SARS-CoV-2 infection to progress to an uncontrolled hyperinflammatory response

 

MERS-CoV and SARS-CoV-2 replication can be inhibited by targeting the interaction between the viral spike protein and the nucleocapsid protein

February 6, 2021 - The molecular interactions between viral proteins form the basis of virus production and can be used to develop strategies against virus infection

 

Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial

February 05, 2021 - To date, only monoclonal antibodies have been shown to be effective for outpatients with COVID-19. Interferon lambda-1 is a type III interferon involved in innate antiviral responses with activity against respiratory pathogens

 

The use of mesenchymal stem cells in the process of treatment and tissue regeneration after recovery in patients with Covid-19

February 04, 2021 - In addition to causing health concerns, the new coronavirus has been considered in the world with its unknown mechanism of physiopathogenesis and long-term effects after patient recovery

 

Remdesivir for treatment of COVID-19; an updated systematic review and meta-analysis

February 04, 2021 - The coronavirus disease 2019 (COVID-19) pandemic has become a global health crisis

 

Anti‑infection mechanism of phosphodiesterase‑5 inhibitors and their roles in coronavirus disease 2019 (Review)

February 3, 2021 - Coronavirus disease 2019 (COVID‑19) has a variety of impacts on the human body

 

Immunoregulatory therapy strategies that target cytokine storms in patients with COVID‑19 (Review)

February 3, 2021 - A cytokine storm is an uncontrolled, excessive immune response that contributes to the pathogenesis of coronavirus disease 2019 (COVID‑19)

 

Structural insights into SARS-CoV-2 infection and therapeutics development

February 02, 2021 - The current COVID-19 pandemic is caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)

 

SARS-CoV-2: From the pathogenesis to potential anti-viral treatments

February 02, 2021 - The world is witnessing the spread of one of the members of Coronaviruses (CoVs) family, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the 21st century

 

Colchicine and SARS-CoV-2: Management of the hyperinflammatory state

January 31, 2021 - The global COVID-19 pandemic is currently underway. In December 2020, the European Agency of Medicine (EMA) licensed the first Sars-CoV-2 vaccine

 

Current concepts in the development of therapeutics against human and animal coronavirus diseases by targeting NP

January 30, 2021 - The coronavirus (CoV) infects a broad range of hosts including humans as well as a variety of animals

 

Targets and strategies for vaccine development against SARS-CoV-2

January 28, 2021 - The SARS-CoV-2, previously called a novel coronavirus, that broke out in the Wuhan city of China caused a significant number of morbidity and mortality in the world

 

COVID-19: Before the Fall, An Evidence-Based Narrative Review of Treatment Options

January 25, 2021 - The 2019 novel coronavirus (COVID-19) has quickly become one of the most dire international pandemic crises since the 1918 Spanish flu

 

COVID-19: Characteristics and Therapeutics

January 21, 2021 - Novel coronavirus (COVID-19 or 2019-nCoV or SARS-CoV-2), which suddenly emerged in December 2019 is still haunting the entire human race and has affected not only the healthcare system but also the global socioeconomic balances

 

Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19

January 21, 2021 - Coronavirus disease 2019 (COVID-19) continues to spread rapidly worldwide. Neutralizing antibodies are a potential treatment for COVID-19

 

Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19

January 21, 2021 - Importance  Coronavirus disease 2019 (COVID-19) continues to spread rapidly worldwide. Neutralizing antibodies are a potential treatment for COVID-19

 

SARS-CoV-2 RNA dependent RNA polymerase as a therapeutic target for COVID-19

January 21, 2021 - The current SARS-CoV-2 pandemic urgently demands for both prevention and treatment strategies

 

Targeting SARS-CoV-2 Viral Proteases as a Therapeutic Strategy to Treat COVID-19

January 21, 2021 - The 21st century has witnessed three outbreaks of coronavirus (CoVs) infections caused by severe acute respiratory syndrome (SARS)‐CoV, Middle East respiratory syndrome (MERS)‐CoV and SARS‐CoV‐2

 

In silico study indicates antimalarials as direct inhibitors of SARS-CoV-2-RNA dependent RNA polymerase

January 21, 2021 - Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused a global pandemic

 

Enisamium is an inhibitor of the SARS-CoV-2 RNA polymerase and shows improvement of recovery in COVID-19 patients in an interim analysis of a clinical trial

January 21, 2021 - Pandemic SARS-CoV-2 causes a mild to severe respiratory disease called Coronavirus Disease 2019 (COVID-19)

 

Recombinant interleukin-2 stimulates lymphocyte recovery in patients with severe COVID-19

January 18, 2021 - A recently identified type of pneumonia, referred to as coronavirus disease 2019 (COVID‑19), which is caused by severe acute respiratory syndrome coronavirus‑2, has rapidly spread worldwide

 

Pharmacological strategies to prevent SARS-CoV-2 infection and to treat the early phases of COVID-19 disease

January 18, 2021 - A novel coronavirus known as SARS-CoV-2 causing the human COVID-19 disease, emerged in China and is spreading worldwide

 

Cholesterol 25-hydroxylase suppresses porcine deltacoronavirus infection by inhibiting viral entry

January 18, 2021 - Cholesterol 25-hydroxylase (CH25 H) is a key enzyme regulating cholesterol metabolism and also acts as a broad antiviral host restriction factor

 

An in silico analysis of Ibuprofen enantiomers in high concentrations of sodium chloride with SARS-CoV-2 main protease

January 18, 2021 - 2020 will be remembered worldwide for the outbreak of Coronavirus disease (COVID-19), which quickly spread until it was declared as a global pandemic

 

Molecular docking and simulation studies of natural compounds of Vitex negundo L. against papain-like protease (PLpro) of SARS CoV-2 (coronavirus) to conquer the pandemic situation in the world

January 18, 2021 - The severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is β-coronavirus that is responsible for the pandemic coronavirus disease 2019 (COVID-19) all over the world

 

Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages

January 14, 2021 - Cannabis sativa is widely used for medical purposes and has anti-inflammatory activity

 

Efficacy of synthetic glucocorticoids in COVID-19 endothelites

January 14, 2021 - Since March 2020, the world has been fighting a global pandemic caused by a new coronavirus SARS-CoV-2 (COVID-19)

 

Perinatal Cells: A Promising COVID-19 Therapy?

January 14, 2021 - The COVID-19 pandemic has become a priority in the health systems of all nations worldwide. In fact, there are currently no specific drugs or preventive treatments such as vaccines

 

A novel ratio of CD8+:B-cells as a prognostic marker of coronavirus disease 2019 patient progression and outcome

January 13, 2021 - Infection with SARS-COV-2 may result in severe pneumonia potentially leading to mechanical ventilation and intensive care treatment

 

Manipulated bio antimicrobial peptides from probiotic bacteria as proposed drugs for COVID-19 disease

January 12, 2021 - Coronavirus disease 19 (COVID-19) is the latest pandemic resulted from the coronavirus family

 

In silico exploration of novel protease inhibitors against coronavirus 2019 (COVID-19)

January 12, 2021 - The spread of SARS-CoV-2 has affected human health globally. Hence, it is necessary to rapidly find the drug-candidates that can be used to treat the infection

 

Acquired factor V inhibitor in the setting of coronavirus disease 2019 infection

January 12, 2021 - Factor V inhibitors are a rare cause of life-threatening bleeding. We present a case of an acquired factor V inhibitor likely caused by coronavirus disease 2019 infection

 

In silico validation of potent phytochemical Orientin as inhibitor of SARS-CoV-2 spike and host cell receptor GRP78 binding

January 11, 2021 - The present wellbeing worry to the whole world is the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also called COVID-19

 

ACE-2-interacting Domain of SARS-CoV-2 (AIDS) Peptide Suppresses Inflammation to Reduce Fever and Protect Lungs and Heart in Mice: Implications for COVID-19 Therapy

January 11, 2021 - COVID-19 is an infectious respiratory illness caused by the virus strain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and until now, there is no effective therapy against COVID-19

 

Review of pharmacologic and immunologic agents in the management of COVID-19

January 9, 2021 - The novel coronavirus disease 2019 (COVID-19) is the third coronavirus outbreaks in the last two decades

 

Impact of oral anticoagulation on clinical outcomes of COVID-19: a nationwide cohort study of hospitalized patients in Germany

January 8, 2021 - The aim of this study was to investigate the impact of concomitant long-term medication—with a focus on ACE inhibitors and oral anticoagulation—on clinical outcomes in patients hospitalized with coronavirus disease 2019

 

Immune system response during viral Infections: Immunomodulators, cytokine storm (CS) and Immunotherapeutics in COVID-19

January 7, 2021 - Coronaviruses are non-segmented and single stranded positive-sense RNA (+ssRNA) viruses

 

Potential Role of Zinc in the COVID-19 Disease Process and its Probable Impact on Reproduction

January 7, 2021 - COVID-19 (coronavirus disease 2019) is the current world health crisis, producing extensive morbidity and mortality across all age groups

 

Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections

January 7, 2021 - Interleukin-38 has recently been shown to have anti-inflammatory properties in lung inflammatory diseases

 

Disruption of CCR5 signaling to treat COVID-19-associated cytokine storm: Case series of four critically ill patients treated with leronlimab

January 6, 2021 - Coronavirus disease 2019 (COVID-19) is associated with considerable morbidity and mortality

 

Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

January 6, 2021 - Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive

 

Matched cohort study on the efficacy of tocilizumab in patients with COVID-19

January 5, 2021 - Tocilizumab has been proposed as a treatment for the new disease COVID-19, however, there is not enough scientific evidence to support this treatment

 

Review on COVID-19 Etiopathogenesis, Clinical Presentation and Treatment Available with Emphasis on ACE2

January 3, 2021 - In December 2019, Wuhan city in the Hubei province of China reported for the first time a cluster of patients infected with a novel coronavirus, since then there has been an outburst of this disease across the globe affecting millions of human inhabitants

 

Network pharmacology-based analysis of zukamu granules for the treatment of COVID-19

January 2, 2021 - Zukamu granules may play a potential role in the fight against the Coronavirus, COVID-19

 

Renin-angiotensin system blockers, risk of SARS-CoV-2 infection and outcomes fromCoViD-19: systematic review and meta-analysis

December 31, 2020 - Concern has been raised about the safety of the renin–angiotensin system (RAS) blockers in relation to infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)

 

Molecular Insights into the MAPK Cascade during Viral Infection: Potential Crosstalk between HCQ and HCQ Analogues

December 31, 2020 - The mitogen-activated protein kinase (MAPK) pathway links the cell-surface receptors to the transcription machinery, transducing the extracellular signals into several outputs, which may also adapt the host defense mechanism to viral attacks

 

A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening

December 29, 2020 - The unparalleled global effort to combat the continuing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic over the last year has resulted in promising prophylactic measures

 

Clinical Outcomes From COVID-19 Following Use of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers Among Patients with Hypertension in South Korea: A nationwide study

December 29, 2020 - Recent evidence show no harm associated with the use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin-receptor blockers (ARBs) and coronavirus disease-2019 (COVID-19)

 

A Comprehensive Analysis of cis-Acting RNA Elements in the SARS-CoV-2 Genome by a Bioinformatics Approach

December 23, 2020 - The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes severe respiratory disease in humans, is called the coronavirus disease of 2019 (COVID-19)

 

Computational Prediction of Potential Inhibitors of the Main Protease of SARS-CoV-2

December 23, 2020 - The rapidly developing pandemic, known as coronavirus disease 2019 (COVID-19) and caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently spread across 213 countries and territories

 

Computational and network pharmacology analysis of bioflavonoids as possible natural antiviral compounds in COVID-19

December 23, 2020 - Bioflavonoids are the largest group of plant-derived polyphenolic compounds with diverse biological potential and have also been proven efficacious in the treatment of Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS)

 

The Need for Antiviral Drugs for Pandemic Coronaviruses From a Global Health Perspective

December 22, 2020 - Respiratory failure due to SARS-CoV-2 has caused widespread mortality, creating an urgent need for effective treatments and a long-term need for antivirals for future emergent coronaviruses

 

Sofosbuvir and daclatasvir for the treatment of COVID-19 outpatients: a double-blind, randomized controlled trial

December 18, 2020 - Effective treatments are urgently needed to tackle the novel coronavirus disease 2019 (COVID-19)

 

Biochemical and biophysical characterization of the main protease, 3-chymotrypsin-like protease (3CLpro) from the novel coronavirus SARS-CoV 2

December 17, 2020 - Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is responsible for the novel coronavirus disease 2019 (COVID-19)

 

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

December 17, 2020 - Recent data suggest that complications and death from coronavirus disease 2019 (Covid-19) may be related to high viral loads

 

Dexamethasone Vs. COVID‐19: An Experimental Study in Line with the Preliminary Findings of a Large Trial

December 17, 2020 - The preliminary report of the RECOVERY large randomized controlled trial indicated a promising survival effect for dexamethasone therapy of coronavirus disease 2019 (COVID‐19)

 

SARS-CoV-2–specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein

December 17, 2020 - T-cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been described in recovered patients, and may be important for immunity following infection and vaccination as well as for the development of an adoptive immunotherapy for the treatment of immunocompromised individuals

 

A retrospective comparison of drugs against COVID-19

December 14, 2020 - Coronavirus disease 19 (COVID-19) has posed serious threats to the general population

 

Anti-IL-6 receptor antibody treatment for severe COVID-19 and the potential implication of IL-6 gene polymorphisms in novel coronavirus pneumonia

December 13, 2020 - Despite the rapid global increase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, there is currently no effective treatment for patients who have developed severe coronavirus disease 2019 (COVID-19)

 

Drug Repurposing for COVID-19 using Graph Neural Network with Genetic, Mechanistic, and Epidemiological Validation

December 11, 2020 - Amid the pandemic of 2019 novel coronavirus disease (COVID-19) infected by SARS-CoV-2, a vast amount of drug research for prevention and treatment has been quickly conducted, but these efforts have been unsuccessful thus far

 

Tocilizumab and COVID-19: A Meta-Analysis of 2120 Patients with Severe Disease and Implications for Clinical Trial Methodologies

December 2020 - Since the outbreak of the COVID-19, numerous therapies to counteract severe 4 disease have emerged. The benefits of Tocilizumab for severely infected COVID-19 patients 5 and the methodologies of ongoing clinical trials are explored

Genetic mechanisms of critical illness in Covid-19

December 11, 2020 - Host-mediated lung inflammation is present,1 and drives mortality,2 in critical illness caused by Covid-19

 

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

December 11, 2020 - Severe coronavirus disease 2019 (Covid-19) is associated with dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus kinase inhibitor, plus remdesivir are not known

 

A data-driven approach to identify risk profiles and protective drugs in COVID-19

December 10, 2020 - The global outbreak of COVID-19 infections generated an unprecedented need to develop novel therapeutic strategies

 

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

December 10, 2020 - A subset of critically ill COVID-19 patients develop a hyperinflammatory state. Anakinra, a recombinant interleukin-1 receptor antagonist, is known to be effective in several hyperinflammatory diseases

 

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

December 10, 2020 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (Covid-19) have afflicted tens of millions of people in a worldwide pandemic

 

Recent progress in the repurposing of drugs/molecules for the management of COVID-19

December 10, 2020 - In the current scenario, COVID-19 is a clinical and public health problem globally

 

Statins and PCSK9 inhibitors: What is their role in coronavirus disease 2019?

December 09, 2020 - Statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors interfere with several pathophysiological pathways of coronavirus disease 2019 (COVID-19)

 

Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies

December 8, 2020 - Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the SARS-CoV-2 spike protein is an envelope glycoprotein that binds angiotensin converting enzyme 2 as an entry receptor

 

Remdesivir for the treatment of coronavirus COVID-19: a meta-analysis of randomised controlled trials

December 08, 2020 - A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing COVID-19, was identified in December 2019 and rapidly spread worldwide

 

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

December 08, 2020 - A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic

 

HMGB1 as a Potential Biomarker and Therapeutic Target for Severe COVID-19

December 07, 2020 - COVID-19 has attracted global attention due to its rapid spread around the world with substantial morbidity and associated mortality 

 

Impact of repurposed drugs on the symptomatic COVID-19 patients

December 07, 2020 - An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus capable of causing coronavirus disease 2019 (COVID-19), was declared as a global public health emergency on January 30, 2020, by the World Health Organization

 

Transcriptional response modules characterise IL-1β and IL-6 activity in COVID-19

December 07, 2020 - Dysregulated IL-1β and IL-6 responses have been implicated in the pathogenesis of severe Coronavirus Disease 2019 (COVID-19)

 

Effect of nelfinavir stereoisomers on coronavirus main protease: Molecular docking, molecular dynamics simulation and MM/GBSA study

December 04, 2020 - In this study, the binding strength of 32 diastereomers of nelfinavir, a proposed drug for the treatment of COVID-19, was considered against main protease

 

Plant-based vaccines and antibodies to combat COVID-19: current status and prospects

December 03, 2020 - Globally, researchers are undertaking significant efforts to design and develop effective vaccines, therapeutics, and antiviral drugs to curb the spread of coronavirus disease 2019 (COVID-19)

 

New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment

December 03, 2020 - Melatonin may be a powerful auxiliary therapy in the prevention and treatment of viral infections, such as coronavirus disease 2019 (COVID-19)

 

Micro-RNAs in the regulation of immune response against SARS COV-2 and other viral infections

December 02, 2020 -Micro-RNAs (miRNAS) are non-coding, small RNAs that have essential roles in different biological processes through silencing genes, they consist of 18-24 nucleotide length RNA molecules

 

COVID-19 and cancer: From basic mechanisms to vaccine development using nanotechnology

December 02, 2020 - Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global pandemic which has induced unprecedented ramifications, severely affecting our society due to the long incubation time, unpredictably high prevalence and lack of effective vaccines

 

2-Pyridone natural products as inhibitors of SARS-CoV-2 main protease

December 02, 2020 - The disease, COVID-19, is caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2) for which there is currently no treatment

 

Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease

December 1, 2020 - The cell surface protein TMPRSS2 (transmembrane protease serine 2) is an androgen-responsive serine protease important for prostate cancer progression and therefore an attractive therapeutic target

 

Clinically Approved Antiviral Drug in an Orally Administrable Nanoparticle for COVID-19

December 01, 2020 - There is urgent therapeutic need for COVID-19, a disease for which there are currently no widely effective approved treatments and the emergency use authorized drugs do not result in significant and widespread patient improvement

 

Clinically Approved Antiviral Drug in an Orally Administrable Nanoparticle for COVID-19

December 01, 2020 - There is urgent therapeutic need for COVID-19, a disease for which there are currently no widely effective approved treatments and the emergency use authorized drugs do not result in significant and widespread patient improvement

 

Investigation of beta-lactoglobulin derived bioactive peptides against SARS-CoV-2 (COVID-19): in silico analysis

December 01, 2020 - The coronavirus disease of 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which started in late 2019 in Wuhan, China spread to the whole world in a short period of time, and thousands of people have died due to this epidemic

 

High rate of major drug–drug interactions of lopinavir–ritonavir for COVID-19 treatment

December 01, 2020 - The impact of drug–drug interactions (DDI) between ritonavir-boosted lopinavir (LPV-r) to treat patients with coronavirus disease 2019 (COVID-19) and commonly used drugs in clinical practice is not well-known

 

D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization

December 01, 2020 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein acquired a D614G mutation early in the pandemic that confers greater infectivity and is now the globally dominant form

 

Narrative review of the novel coronavirus SARS-CoV-2: update on genomic characteristics, transmissions and animal model

November 30, 2020 - Two outbreaks of severe respiratory infection caused by severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) caused global pandemics and highlighted the importance of preparedness for respiratory CoVs

 

Challenges and stepwise fit-for-purpose optimization for bioanalyses of remdesivir metabolites nucleotide monophosphate and triphosphate in mouse tissues using LC–MS/MS

November 30, 2020 - Remdesivir is a prodrug of the nucleotide analogue and used for COVID-19 treatment

 

A Neutralizing Antibody-Conjugated Photothermal Nanoparticle Captures and Inactivates SARS-CoV-2

November 30, 2020 - The outbreak of 2019 coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic

How Could In Vitro Antiviral Activity Be Applied to Optimize the Dosing Regimens of Candidates for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)?

November 27, 2020 - Recently, Yao et al reported an optimized dosing regimen design of hydroxychloroquine (HCQ) for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on model and simulation (M&S)

 

The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines

November 26, 2020 - The coronavirus disease 2019 (COVID-19) pandemic has created an urgent need for therapeutics that inhibit the SARS−COV-2 virus and suppress the fulminant inflammation characteristic of advanced illness

 

Aerosol inhalation delivery of triazavirin in mice: outlooks for advanced therapy against novel viral infections

November 25, 2020 - Under pandemic-caused emergency, evaluation of the potential of existing antiviral drugs for the treatment of COVID-19 is relevant. Triazavirin, an antiviral drug developed in Russia for per-oral administration, is involved in clinical trials against SARS-CoV-2 coronavirus

 

SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?

November 25, 2020 - Since the outbreak of the new coronavirus in 2019 (SARS-CoV-2), many studies have been performed to better understand the basic mechanisms and clinical features of the disease

 

DFT and Molecular Docking Study of Chloroquine Derivatives as Antiviral to Coronavirus COVID-19

November 25, 2020 - The recently emerged COVID-19 virus caused hundreds of thousands of deaths and instigated a widespread fear, threatening the world’s most advanced health security

 

A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro

November 24, 2020 - We recently discovered a superantigen-like motif, similar to Staphylococcal enterotoxin B (SEB), near the S1/S2 cleavage site of SARS-CoV-2 Spike protein, which might explain the multisystem-inflammatory syndrome (MIS-C) observed in children and cytokine storm in severe COVID-19 patients

 

Identification of natural inhibitors against prime targets of SARS-CoV-2 using molecular docking, molecular dynamics simulation and MM-PBSA approaches

November 13, 2020 - The recently emerged COVID-19 has been declared a pandemic by the World Health Organization as to date; no therapeutic drug/vaccine is available for the treatment

 

Virulence and pathogenesis of SARS-CoV-2 infection in rhesus macaques: A nonhuman primate model of COVID-19 progression

November 12, 2020 - The COVID-19 has emerged as an epidemic, causing severe pneumonia with a high infection rate globally

 

Repurposing therapeutics for COVID-19: Rapid prediction of commercially available drugs through machine learning and docking

November 12, 2020 - The outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus has spread rapidly around the globe during the past 3 months

 

Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets

November 10, 2020 - Patients with colorectal cancer (CRC) may be susceptible to the coronavirus disease-2019 (COVID-19)

 

COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice

November 09, 2020 - The ongoing COVID-19 pandemic is associated with substantial morbidity and mortality

 

A pharmacology‐based comprehensive review on medicinal plants and phytoactive constituents possibly effective in the management of COVID‐19

November 06, 2020 - Arisen in China, COVID‐19 (SARS‐CoV‐II) is a novel coronavirus that has been expanding fast worldwide

 

An overview of antiviral strategies for coronavirus 2 (SARS-CoV-2) infection with special reference to antimalarial drugs chloroquine and hydroxychloroquine

November 06, 2020 - At present, neither specific antiviral drugs, nor vaccine is recommended for coronavirus disease 2019 (COVID‐19) treatment

 

Searching for target-specific and multi-targeting organics for Covid-19 in the Drugbank database with a double scoring approach

November 05, 2020 - The current outbreak of Covid-19 infection due to SARS-CoV-2, a virus from the coronavirus family, has become a major threat to human healthcare

 

Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2

November 05, 2020 - Cost-effective, efficacious therapeutics are urgently needed against the COVID-19 pandemic

 

An overview on the use of antivirals for the treatment of patients with COVID19 disease

November 05, 2020 - There is an urgent need for safe and efficacious antiviral drugs to improve outcomes for COVID-19 patients

 

Remdesivir for the Treatment of Covid-19 — Final Report

November 05, 2020 - Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), no antiviral agents have yet been shown to be efficacious

 

Canadian Immunization Guide: “Anaphylaxis and other acute reactions following vaccination” chapter update

November 5, 2020 - The Canadian Immunization Guide (CIG) is a comprehensive resource on immunization for health professionals and vaccine program decision-makers

 

Insights from nanotechnology in COVID-19 treatment

November 04, 2020 - In just a few months, SARS-CoV-2 and the disease it causes, COVID-19, created a worldwide pandemic

 

Computer aided identification of potential SARS CoV-2 main protease inhibitors from diterpenoids and biflavonoids of Torreya nucifera leaves

November 3, 2020 - SARS CoV-2 is the causative agent of the pandemic disease COVID-19. There is an urgent need for effective drugs or vaccines which can effectively combat this outbreak

 

Toward COVID-19 Therapeutics: A Viewpoint from the Nonprotein Amino Acid Based Synthetic Peptide Design Approach

November 3, 2020 - Cell entry, the fundamental step in cross-species transmission of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), is initiated by the recognition of the host cell angiotensin-converting enzyme-2 (ACE2) receptor by the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2

 

CRISPR-Cas System: An Approach With Potentials for COVID-19 Diagnosis and Therapeutics

November 02, 2020 - COVID-19, the human coronavirus disease caused by SARS-CoV-2, was reported for the first time in Wuhan, China in late 2019

 

Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection

November 2, 2020 - Effective therapies are urgently needed for the SARS-CoV-2/COVID-19 pandemic. We identified panels of fully human monoclonal antibodies (mAbs) from large phage-displayed Fab, scFv, and VH libraries by panning against the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) glycoprotein

 

New Perspectives on Antimicrobial Agents: Remdesivir Treatment for COVID-19

November 2, 2020 - Remdesivir was recently approved by the Food and Drug Administration for the treatment of hospitalized patients with COVID-19

 

Hyperimmune anti-COVID-19 IVIG (C-IVIG) Therapy for Passive Immunization of Severe and Critically Ill COVID-19 Patients: A structured summary of a study protocol for a randomised controlled trial

November 2, 2020 - The aim of this trial is to investigate the safety and clinical efficacy of passive immunization therapy through Hyperimmune anti-COVID-19 Intravenous Immunoglobulin (C-IVIG: 5% liquid formulation), on severe and critically ill patients with COVID-19

 

Safety and efficacy of Artemisinin-Piperaquine for treatment of COVID-19: an open-label, non-randomized, and controlled trial

November 2, 2020 - In patients with mild to moderate COVID-19, the time to reach undetectable SARS-CoV-2 was significantly shorter in the AP group than that in the control group

 

GM-CSF Neutralization With Lenzilumab in Severe COVID-19 Pneumonia

November 01, 2020 - To assess the efficacy and safety of lenzilumab in patients with severe coronavirus disease 2019 (COVID-19) pneumonia

 

Boceprevir, calpain inhibitors II and XII, and GC-376 have broad-spectrum antiviral activity against coronaviruses in cell culture

November 1, 2020 - As the COVID-19 pandemic continues to fold out, the morbidity and mortality are increasing daily

 

Integrative transcriptome analyses empower the anti-COVID-19 drug arsenal

November, 2020 - The beginning of the 21st century has been marked by three distinct waves of zoonotic coronavirus outbreaks into the human population

 

Combined Interventions for Severe Novel Coronavirus Disease (COVID-19): Experience from 350 Patients

October 30, 2020 - In this retrospective, multicenter study, the medical records of COVID-19 patients in Hunan, from January 21, 2020 to February 19, 2020 were reviewed

 

Atorvastatin and Aspirin as Adjuvant Therapy in Patients with SARS-CoV-2 Infection: A structured summary of a study protocol for a randomised controlled trial

October 30, 2020 - To assess the impact of adding statin (atorvastatin) and/or aspirin on clinical deterioration in patients infected with SARS-CoV-2 who require hospitalisation

 

Exploring RdRp-remdesivir interactions to screen RdRp inhibitors for the management of novel coronavirus 2019-nCoV

October 26, 2020 - A novel coronavirus recently identified in Wuhan, China (2019-nCoV) has resulted in an increasing number of patients globally, and has become a highly lethal pathogenic member of the coronavirus family affecting humans

 

Use of a Humanized Anti-CD6 Monoclonal Antibody (Itolizumab) in Elderly Patients with Moderate COVID-19

October 26, 2020 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a recent outbreak of coronavirus disease (COVID-19). In Cuba, the first case of COVID-19 was reported on March 11, 2020

 

Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing

October 22, 2020 - Remdesivir exhibits in vitro activity against SARS-CoV-2 and was granted approval for emergency use. To maximize delivery to the lungs, we formulated remdesivir as a dry powder for inhalation using thin film freezing (TFF)

 

Discovery of small molecule PLpro inhibitor against COVID-19 using structure-based virtual screening, molecular dynamics simulation, and molecular mechanics/Generalized Born surface area (MM/GBSA) calculation

October 22, 2020 - COVID-19 is spreading in a global pandemic that is endangering human life and health. Therefore, there is an urgent need to target COVID-19 to find effective treatments for this emerging acute respiratory infection

 

A potential treatment for COVID-19 based on modal characteristics and dynamic responses analysis of 2019-nCoV

October 21, 2020 - The 2019-nCoV is ravaging the world, taking lots of lives, and it is emergent to find a solution to deal with this novel pneumonia

Clinical features and antibody response of patients from a COVID-19 treatment hospital in Wuhan, China

October 21, 2020 - A total of 1578 patients admitted into a newly built hospital specialized for COVID‐19 treatment in Wuhan, China, were enrolled. Clinical features and the levels of SARS‐CoV‐2 IgM and IgG were analyzed

 

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

October 21, 2020 - The efficacy of interleukin-6 receptor blockade in hospitalized patients with coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear

 

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary  human airway epithelium

October 19, 2020 - The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-sequencing to understand how the heterogeneity of this diverse cell population contributes to elements of viral tropism and pathogenesis, antiviral immunity, and treatment response to remdesivir

 

Favipiravir as an antiviral agent in COVID-19: same script, different cast?

October 19, 2020 - Publicado pela Oxford University Press para a Infectious Diseases Society of America

 

Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection

October 17, 2020 - Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is currently causing a worldwide pandemic with high morbidity and mortality

 

Infusion of HLA-matched and static magnetic field-exposed allogenic lymphocytes treating lymphocytopenia and cytokine storm syndrome: A treatment proposal for COVID-19 patients

October 17, 2020 - Among haematological parameters of patients seriously ill with the coronavirus infectious disease 2019 (COVID-19), leucocytosis, lymphocytopenia, and the abnormal release of circulating cytokines, termed cytokine storm syndrome (CSS, also known as cytokine release syndrome or CRS), were found associated with disease severity

 

Methylene blue inhibits the replication of SARS-Cov-2 in vitro

October 16, 2020 - In December 2019, a new severe acute respiratory syndrome coronavirus (SARS-CoV-2) causing coronavirus diseases 2019 (COVID-19) emerged in Wuhan, China

 

Computer-aided drug design against spike glycoprotein of SARS-CoV-2 to aid COVID-19 treatment

October 15, 2020 - The current study was conducted to explore drugs against Receptor Binding Domain (RBD) of SARS-CoV-2 using in silico pharmacophore modelling and virtual screening approach to combat COVID-19

 

Clinical efficacy of intravenous immunoglobulin therapy in critical ill patients with COVID‐19: a multicenter retrospective cohort study

October 14, 2020 - Coronavirus disease 2019 (COVID‐19) outbreak is a major challenge all over the world, without acknowledged treatment

 

Molecular screening of antimalarial, antiviral, anti-inflammatory and HIV protease inhibitors against spike glycoprotein of coronavirus 

October 13, 2020 - Coronavirus outbreak in December 2019 (COVID-19) is an emerging viral disease that poses major menace to Humans and it’s a crucial need to find the possible treatment strategies

 

Evaluation of alpha defensin, IL-1 receptor antagonist, and IL-18 levels in COVID-19 patients with macrophage activation syndrome and acute respiratory distress syndrome

October 10, 2020 - Many laboratory parameters have been associated with morbidity and mortality in SARS‐CoV‐2 (COVID‐19), which emerged in an animal market in Wuhan, China in December 2019 and has infected over 20 million people

 

Structural and molecular basis of the interaction mechanism of selected drugs towards multiple targets of SARS-CoV-2 by molecular docking and dynamic simulation studies- deciphering the scope of repurposed drugs

October 9, 2020 - The repurposing of FDA approved drugs is presently receiving attention for COVID-19 drug discovery

 

Hot spot profiles of SARS-CoV-2 and human ACE2 receptor protein protein interaction obtained by density functional tight binding fragment molecular orbital method

October 08, 2020 - The prevalence of a novel β-coronavirus (SARS-CoV-2) was declared as a public health emergency of international concern on 30 January 2020 and a global pandemic on 11 March 2020 by WHO

 

Tackling SARS‐CoV‐2 Infections using Remdesivir and Favipiravir as Therapeutic Options

October 08, 2020 - The outbreak of pandemic COVID‐19 causes severe damage to the human world, including infections, deaths, and economic disruptions. The world has focused on developing treatment and controlling measures against COVID‐19

 

Angiotensin‐converting enzyme 2: A protective factor in regulating disease virulence of SARS‐COV‐2

October 08, 2020 - Novel SARS‐CoV‐2 named due to its close homology with severe acute respiratory syndrome coronavirus (SARS‐CoV) is the etiologic agent for the ongoing pandemic outbreak causing loss of life and severe economic burden globally

 

Efficacy and safety of tocilizumab in COVID-19 patients

October 08, 2020 - In this retrospective study we assessed the efficacy and safety of tocilizumab in patients with critical or severe coronavirus disease 2019 (COVID-19)

 

Rapamycin as a potential repurpose drug candidate for the treatment of COVID-19

October 06, 2020 - The novel human coronavirus-2 (HCoV-2), called SARS-CoV-2, is the causative agent of Coronavirus Induced Disease (COVID-19) and has spread causing a global pandemic

 

A Systems Biology Workflow for Drug and Vaccine Repurposing: Identifying Small-Molecule BCG Mimics to Reduce or Prevent COVID-19 Mortality

October 6, 2020 - Coronavirus disease 2019 (COVID-19) is expected to continue to cause worldwide fatalities until the World population develops ‘herd immunity’, or until a vaccine is developed and used as a prevention

 

COVID-19: molecular targets, drug repurposing and new avenues for drug discovery

October 2, 2020 - Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing opportunities for development of new treatments based on current knowledge of the mechanism of infection and potential targets within

 

ACTIVating Resources for the COVID-19 Pandemic: In Vivo Models for Vaccines and Therapeutics

October 01, 2020 - The Preclinical Working Group of Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV), a public-private partnership spearheaded by the National Institutes of Health, has been charged with identifying, prioritizing, and communicating SARS-CoV-2 preclinical resources

 

Antiviral activity of digoxin and ouabain against SARS-CoV-2 infection and its implication for COVID-19

October 01, 2020 - The current coronavirus (COVID-19) pandemic is exacerbated by the absence of effective therapeutic agents. Notably, patients with COVID-19 and comorbidities such as hypertension and cardiac diseases have a higher mortality rate

 

Targeting the SARS-CoV‑2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders

September 30, 2020 - COVID-19 is a global pandemic, thus requiring multiple strategies to develop modalities against it. Herein, we designed multiple bioactive small molecules that target a functional structure within the SARS-CoV-2’s RNA genome, the causative agent of COVID-19

 

Genetics and genomics of SARS-CoV-2: A review of the literature with the special focus on genetic diversity and SARS-CoV-2 genome detection

September 30, 2020 - The outbreak of 2019-novel coronavirus disease (COVID-19), caused by SARS-CoV-2, started in late 2019; in a short time, it has spread rapidly all over the world

 

Interaction of Human ACE2 to Membrane-Bound SARS-CoV-1 and SARS-CoV-2 S Glycoproteins

September 29, 2020 - Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is responsible for the current global coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundreds of thousands of deaths

 

Low-to-moderate dose corticosteroids treatment in hospitalized adults with COVID-19

September 29, 2020 - Use of corticosteroids is common in the treatment of coronavirus disease 2019, but the clinical effectiveness was controversial. We aimed to investigate the association of corticosteroids therapy with clinical outcomes of hospitalized COVID-19 patients

 

Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression

September 29, 2020 - Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak emerged, countless efforts are being made worldwide to understand the molecular mechanisms underlying the coronavirus disease 2019 (COVID-19) in an attempt to identify the specific clinical characteristics of critically ill COVID-19 patients involved in its pathogenesis and provide therapeutic alternatives to minimize COVID-19 severity

 

Presence of hyaluronan in lung alveoli in severe Covid-19 - an opening for new treatment options?

September 25, 2020 - Severe corona virus disease 2019 (Covid-19) is characterized by inflammation of the lungs with increasing respiratory impairment. In fatal Covid-19

 

Inactivation of SARS-CoV-2 and HCoV-229E in vitro by ColdZyme® a medical device mouth spray against common cold

September 25, 2020 - The COVID‐19 pandemic calls for effective and safe treatments. SARS‐CoV‐2 causing COVID‐19 actively replicates in the throat, unlike SARS‐CoV, and shows high pharyngeal viral shedding even in patients with mild symptoms of the disease

 

Favipiravir versus other antiviral or standard of care for COVID-19 treatment: a rapid systematic review and meta-analysis

September 24, 2020 - The COVID-19 causing coronavirus is an enveloped RNA virus that utilizes an enzyme RNA dependent RNA polymerase for its replication

 

Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design

September 24, 2020 - As the SARS-CoV-2 pandemic is rapidly progressing, the need for the development of an effective vaccine is critical

 

COX2 Inhibition in the Treatment of COVID-19: Review of Literature to Propose Celecoxib Repositioning for Randomized Controlled Studies

September 24, 2020 - Coronavirus triggered pulmonary and systemic disease, i.e. systemic inflammatory response to virally triggered lung injury, named as COVID-19 and still ongoing discussions on refining immunomodulation in COVID-19 without COX2 inhibition directed us to search the related literature to point out a potential target (COX2) and a weapon (celecoxib)

 

The novel coronavirus Disease-2019 (COVID-19): Mechanism of action, detection and recent therapeutic strategies

September 24, 2020 - Novel coronavirus SARS-CoV-2, designated as COVID-19 by the World Health Organization (WHO) on the February 11, 2020, is one of the highly pathogenic β‐coronaviruses which infects human

 

Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects

September 23, 2020 - Development of specific antiviral agents is an urgent unmet need for SARS-coronavirus 2 (SARS-CoV-2) infection

 

SARS-CoV-2 vaccines in development

September 23, 2020 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 in China and caused a coronavirus disease 2019 (COVID-19) pandemic

 

Animal models for COVID-19

September 23, 2020 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by introduction of a novel coronavirus into humans in late 2019 in China’s Hubei province

 

Therapeutic versus prophylactic anticoagulation for severe COVID-19: A randomized phase II clinical trial (HESACOVID)

September 20, 2020 - Coronavirus disease 2019 (COVID-19) causes a hypercoagulable state. Several autopsy studies have found microthrombi in pulmonary circulation

 

CRISPR/Cas13: A potential therapeutic option of COVID-19

September 17, 2020 - The novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be considered as the most important current global issue, as it has caused the novel coronavirus disease (COVID-19) pandemic, which has resulted in high mortality and morbidity rates all around the world

 

Pulmonary administration of remdesivir in the treatment of COVID-19

September 17, 2020 - We read, with great interest, the commentary “Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Additional Benefit” by Sun [1]

 

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

September 17, 2020 - SARS-CoV-2 infection is initiated by virus binding to ACE2 cell surface receptors1–4, followed by fusion of virus and cell membranes to release the virus genome into the cell

 

Painel mostra dados sobre medicamentos para Covid-19

17 de setembro de 2020 - Ferramenta traz informações do monitoramento sobre fabricação, importação e distribuição de fármacos utilizados em pacientes infectados pelo Sars-CoV-2

 

Sarilumab versus standard of care for the early treatment of COVID-19 pneumonia in hospitalized patients: SARTRE: a structured summary of a study protocol for a randomised controlled trial

September 16, 2020 - In some patients, acute, life-threatening respiratory injury produced by viruses such as SARS-CoV and other viral pneumonia are associated with an over-exuberant cytokine release

 

Identification of novel human USP2 inhibitor and its putative role in treatment of COVID-19 by inhibiting SARS-CoV-2 papain-like (PLpro) protease

September 13, 2020 - Human ubiquitin carboxyl-terminal hydrolase-2 (USP2) inhibitors, such as thiopurine analogs, have been reported to inhibit SARS-CoV papain-like proteases (PLpro)

 

Identification of potential mRNA panels for severe acute respiratory syndrome coronavirus 2 (COVID-19) diagnosis and treatment using microarray dataset and bioinformatics methods

September 11,2020 - The goal of the present investigation is to identify the differentially expressed genes (DEGs) between SARS-CoV-2 infected and normal control samples to investigate the molecular mechanisms of infection with SARS-CoV-2

 

Safety assessment of drug combinations used in COVID-19 treatment: in silico toxicogenomic data-mining approach

September 11, 2020 - Improvement of COVID-19 clinical condition was seen in studies where combination of antiretroviral drugs, lopinavir and ritonavir, as well as immunomodulant antimalaric, chloroquine/hydroxychloroquine together with the macrolide-type antibiotic, azithromycin, was used for patient's treatment

 

Convalescent plasma anti-SARS-CoV-2 spike protein ectodomain and receptor binding domain IgG correlate with virus neutralization

September 10, 2020 - The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the urgent need for assays that detect protective levels of neutralizing antibodies

 

Virtual screening of approved clinic drugs with main protease (3CLpro) reveals potential inhibitory effects on SARS-CoV-2

September 10, 2020 - 3CLpro is the main protease of the novel coronavirus (SARS-CoV-2) responsible for their intracellular duplication

 

The inorganic polymer, polyphosphate, blocks binding of SARS-CoV-2 spike protein to ACE2 receptor at physiological concentrations

September 6, 2020 - Inorganic polyphosphate (polyP) is a morphogenetically active and metabolic energy-delivering physiological polymer that is released from blood platelets

 

Gastrointestinal symptoms, pathophysiology, and treatment in COVID-19

September 5, 2020 - The novel coronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has emerged and is responsible for the Coronavirus Disease 2019 global pandemic

 

Potential Role of Acacia Senegal (Gum Arabic) as Immunomodulatory Agent among newly diagnosed COVID 19 Patients: A structured summary of a protocol for a randomised, controlled, clinical trial

September 5, 2020 - To investigate the potential efficacy of Acacia Senegal extract Gum Arabic (GA) supplementation as immunomodulatory and anti-inflammatory dietary intervention among newly diagnosed COVID 19 Sudanese patients

 

Terapia medicamentosa para infecções por coronavírus em humanos: revisão sistemática rápida

Setembro de 2020 - O objetivo deste trabalho foi avaliar efeitos de tratamentos medicamentosos para infecções por coronavírus

 

Hydroxychloroquine and Chloroquine Prescribing Patterns by Provider Specialty Following Initial Reports of Potential Benefit for COVID-19 Treatment - United States, January-June 2020

September 4, 2020 - Hydroxychloroquine and chloroquine are approved to treat autoimmune diseases and to prevent and treat malaria. Earlier this year, they were widely reported to be of potential benefit in the prevention and treatment of COVID-19; however, current data indicate that the potential benefits of these drugs do not outweigh their risks

 

Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial

September 4, 2020 - The efficacy and safety of azithromycin in the treatment of COVID-19 remain uncertain. We assessed whether adding azithromycin to standard of care, which included hydroxychloroquine, would improve clinical outcomes of patients admitted to the hospital with severe COVID-19

 

Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia

September 4, 2020 - We developed a heterologous COVID-19 vaccine consisting of two components, a recombinant adenovirus type 26 (rAd26) vector and a recombinant adenovirus type 5 (rAd5) vector, both carrying the gene for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein (rAd26-S and rAd5-S)

 

The COVIRL002 Trial-Tocilizumab for management of severe, non-critical COVID-19 infection: A structured summary of a study protocol for a randomised controlled trial

September 3, 2020 - Tocilizumab is a humanized monoclonal antibody which targets and inhibits interleukin-6 (IL-6) and has demonstrated efficacy in treating diseases associated with hyper-inflammation

 

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19 The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial

September 2, 2020 - Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited

 

Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

September 2, 2020 - NVX-CoV2373 is a recombinant severe acute respiratory syndrome coronavirus 2 (rSARS-CoV-2) nanoparticle vaccine composed of trimeric full-length SARS-CoV-2 spike glycoproteins and Matrix-M1 adjuvant

 

Favipiravir: A new and emerging antiviral option in COVID-19

September 2, 2020 - With over 16 million cases reported from across the globe, the SARS-CoV-2, a mere 125 microns in diameter, has left an indelible impact on our world

 

Statistical design of Phase II/III clinical trials for testing therapeutic interventions in COVID-19 patients

August 31, 2020 - Because of unknown features of the COVID-19 and the complexity of the population affected, standard clinical trial designs on treatments may not be optimal in such patient

 

COVID-19 drug repurposing: A review of computational screening methods, clinical trials, and protein interaction assays

August 30, 2020 -The situation of coronavirus disease 2019 (COVID‐19) pandemic is rapidly evolving, and medical researchers around the globe are dedicated to finding cures for the disease

 

Computation screening and molecular docking of FDA approved viral protease inhibitors as a potential drug against COVID-19

August 29, 2020 - This study demonstrated potent inhibitors against COVID-19 using the molecular docking approach of FDA approved viral antiprotease drug

 

Efficacy of tocilizumab treatment in severely ill COVID-19 patients

August 27, 2020 -The current coronavirus disease 2019 (COVID-19) pandemic induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already caused a global increase in hospitalizations and deaths

 

Design and Evaluation of Anti-SARS-Coronavirus Agents Based on Molecular Interactions with the Viral Protease

August 27, 2020 - Three types of new coronaviruses (CoVs) have been identified recently as the causative viruses for the severe pneumonia-like respiratory illnesses, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and corona-virus disease 2019 (COVID-19)

 

Role of antibody-dependent enhancement (ADE) in the virulence of SARS-CoV-2 and its mitigation strategies for the development of vaccines and immunotherapies to counter COVID-19

August 26, 2020 - Coronavirus disease-2019 (COVID-19) pandemic has become a global threat and death tolls are increasing worldwide

 

The effect of prostacyclin (Iloprost) infusion at a dose of 1 ng/kg/min for 72 hours compared to placebo in mechanically ventilated patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial

August 26, 2020 - To investigate the effect of continuous infusion of the potential endothelial cytoprotective agent prostacyclin (Iloprost) 1 ng/kg/min vs. placebo for 72 hours on pulmonary endotheliopathy in mechanically ventilated COVID-19 patients

 

High dose dexamethasone treatment for Acute Respiratory Distress Syndrome secondary to COVID-19: a structured summary of a study protocol for a randomised controlled trial

August 26, 2020 - The aim of this study is to explore the effectiveness and safety of high dose dexamethasone treatment for Acute Respiratory Distress Syndrome secondary to SARS-Cov-2 pneumonia

 

Dynamics of the ACE2–SARS-CoV-2/SARS-CoV spike protein interface reveal unique mechanisms

August 26, 2020  - The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major public health concern

 

Recent advances in therapeutic modalities and vaccines to counter COVID-19/SARS-CoV-2

August 26, 2020  - The novel coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has rapidly spread across the world

 

Role of antibody-dependent enhancement (ADE) in the virulence of SARS-CoV-2 and its mitigation strategies for the development of vaccines and immunotherapies to counter COVID-19

August 26, 2020 - Coronavirus disease-2019 (COVID-19) pandemic has become a global threat and death tolls are increasing worldwide. The SARS-CoV-2 though shares similarities with SARS-CoV and MERS-CoV, immunopathology of the novel virus is not understood properly

 

COVID-19: Pathophysiology, treatment options, nanotechnology approaches, and research agenda to combating the SARS-CoV2 pandemic

August 23, 2020 -The recent corona virus disease (COVID-19) outbreak has claimed the lives of many around the world and highlighted an urgent need for experimental strategies to prevent, treat and eradicate the virus

 

Virtual screening and molecular dynamics study of approved drugs as inhibitors of spike protein S1 domain and ACE2 interaction in SARS-CoV-2

August 21, 2020 - The receptor binding domain (RBD) of spike protein S1 domain SARS-CoV-2 plays a key role in the interaction with ACE2, which leads to subsequent S2 domain mediated membrane fusion and incorporation of viral RNA into host cells

 

Interleukin-6 in Covid-19: A systematic review and meta-analysis

August 26, 2020 - Coronaviruses may activate dysregulated host immune responses. As exploratory studies have suggested that interleukin-6 (IL-6) levels are elevated in cases of complicated Covid-19, we undertook a systematic review and meta-analysis to assess the evidence in this field

 

Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide

August 20, 2020 - The COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was declared on March 11, 2020 by the World Health Organization

 

An integrated drug repurposing strategy for the rapid identification of potential SARS-CoV-2 viral inhibitors

August 17, 2020 - The Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2)

 

Efficacy of Tocilizumab in Covid 19: A metanalysis of case series studies

August 15, 2020  - Characteristic feature of COVID-19 during its progression in severity is the cytokine storm (via interleukin-6, IL-6) which is responsible for secondary acute respiratory distress syndrome (ARDS) [4]

 

A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge

August 14, 2020 - The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease

 

Clinical characteristics and corticosteroids application of different clinical types in patients with corona virus disease 2019

August 13, 2020 - To describe the epidemiological and clinical characteristics of patients with Corona Virus Disease 2019 (COVID-19) in Beijing

 

A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation

August 13, 2020 - Virus neutralization remains the gold standard for determining antibody efficacy

 

Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults

August 12, 2020 - In March 2020, the World Health Organization (WHO) declared a pandemic of coronavirus disease 2019 (COVID-19), due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)¹

 

Convalescent Plasma Therapy for COVID-19: State of the Art

August 12, 2020 - Convalescent plasma (CP) therapy has been used since the early 1900s to treat emerging infectious diseases; its efficacy was later associated with the evidence that polyclonal neutralizing antibodies can reduce the duration of viremia

 

Anthraquinone Derivatives as an Immune Booster and their Therapeutic Option Against COVID-19

August 08, 2020 - Anthraquinone derivatives are identified for their immune-boosting, anti-inflammatory, and anti-viral efficacy

 

Global multi-omics and systems pharmacological strategy unravel the multi-targeted therapeutic potential of natural bioactive molecules against COVID-19: An in silico approach

August 07, 2020 - Understanding the immunological behavior of COVID-19 cases at molecular level is essential for therapeutic development

 

A systematic review and meta-analysis of the efficacy and safety of western medicine routine treatment combined with Chinese herbal medicine in the treatment of COVID-19

August 07, 2020 - COVID-19 is a global public health emergency. At present, there is no highly effective medicine for the prevention and treatment of 2019-nCoV

 

A Rational Design of a Multi-Epitope Vaccine Against SARS-CoV-2 Which Accounts for the Glycan Shield of the Spike Glycoprotein

August 07, 2020 - The ongoing global health crisis caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus which leads to Coronavirus Disease 2019 (COVID-19) has impacted not only the health of people everywhere, but the economy in nations across the world

 

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

August 06, 2020 - Vaccine efforts against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the current COVID-19 pandemic are focused on SARS-CoV-2 spike glycoprotein, the primary target for neutralizing antibodies

 

Anti-complement C5 therapy with eculizumab in three cases of critical COVID-19

August 06, 2020 - Respiratory failure and acute kidney injury (AKI) are associated with high mortality in SARS-CoV-2-associated Coronavirus disease 2019 (COVID-19)

 

Presidente assina Medida Provisória que garante produção de vacina contra a Covid-19

06 de Agosto de 2020 - Crédito orçamentário de R$ 1,9 bilhão viabilizará a aquisição e produção de 100 milhões de doses da vacina contra a doença, produzida pelo laboratório AtraZeneca e Universidade de Oxford

 

Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm

August 06, 2020 - Several studies show that the immunosuppressive drugs targeting the interleukin-6 (IL-6) receptor, including tocilizumab, ameliorate lethal inflammatory responses in COVID-19 patients infected with SARS-CoV-2

 

Mitochondrial-targeted ubiquinone: A potential treatment for COVID-19

August 5, 2020 - Immune dysregulation characterized by T cell exhaustion and high level of inflammatory cytokines is associated with severe COVID-19

 

A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial

August 05, 2020 - Primary objective: to evaluate the effect of intravenous melatonin (IVM) on mortality in adult patients admitted to the intensive care unit (ICU) with COVID-19

 

​A novel receptor-binding domain (RBD)-based mRNA vaccine against SARS-CoV-2

August 05, 2020 - The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the need to develop effective and safe vaccines

 

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

August 05, 2020 - A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the global coronavirus infectious disease (COVID-19) public health crisis

 

In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication

August 04, 2020  - A novel coronavirus, named SARS-CoV-2, emerged in 2019 in China and rapidly spread worldwide

 

Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers and convalescent plasma donors: a cohort study using a rapid and sensitive high-throughput neutralization assay

August 04, 2020 - Rapid and specific antibody testing is crucial for improved understanding, control, and treatment of COVID-19 pathogenesis

 

De novo design of ACE2 protein decoys to neutralize SARS-CoV-2

August 03, 2020 - We have developed a generalized computational design strategy to rapidly engineer de novo proteins that precisely recapitulate the protein surface targeted by biological agents, like viruses, to gain entry into cells

 

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

August 03, 2020 - Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

 

Identification of promising drug candidates against NSP16 of SARS-CoV-2 through computational drug repurposing study

August 03, 2020 - The recent outbreak of the SARS-CoV-2 virus leading to the disease COVID 19, a global pandemic has resulted in an unprecedented loss of life and economy worldwide

 

Identification of potential drug candidates to combat COVID-19: a structural study using the main protease (mpro) of SARS-CoV-2

August 03, 2020 - The recent outbreak of the SARS-CoV-2 virus leading to the disease COVID 19 has become a global pandemic that is spreading rapidly and has caused a global health emergency

 

Anthocyanin derivatives as potent inhibitors of SARS-CoV-2 main protease: An in-silico perspective of therapeutic targets against COVID-19 pandemic

August 03, 2020 - A new pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide and become pandemic with thousands new deaths and infected cases globally

 

Antirheumatic Disease Therapies for the Treatment of COVID-19: A Systematic Review and Meta-analysis

August 2, 2020 - Antirheumatic disease therapies have been used to treat coronavirus disease 2019 (COVID-19) and its complications. We conducted a systematic review and meta-analysis to describe the current evidence

 

Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil

July 31, 2020 - The first case of COVID-19 was detected in Brazil on 25 February 2020

 

Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients

July 31, 2020 - Human infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and there is no cure currently

 

Single-Dose Nirsevimab for Prevention of RSV in Preterm Infants

July 30, 2020 - Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in infants, and a need exists for prevention of RSV in healthy infants

 

Classification of the present pharmaceutical agents based on the possible effective mechanism on the COVID-19 infection

July 30, 2020 - There are several types of research on the COVID-19 disease which have been conducting

 

Potential treatment methods targeting 2019-nCoV infection

July 28, 2020 - The novel coronavirus, 2019-nCoV, has quickly spread across the world and pose serious threat to public health because it can infect people very easily

 

Hypothesis: Pentoxifylline is a potential cytokine modulator therapeutic in COVID‐19 patients

July 26, 2020 - We propose a new hypothesis that the established drug pentoxifylline deserves attention as a potential repurposed therapeutic for COVID‐19

 

Development of a Multi-Antigenic SARS-CoV-2 Vaccine Using a Synthetic Poxvirus Platform

July, 2020 - Modied Vaccinia Ankara (MVA) is a highly attenuated poxvirus vector that is widely used to develop vaccines for infectious diseases and cancer

 

Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro

July 24, 2020 - COVID-19, caused by the SARS-CoV-2 virus, has now spread worldwide with catastrophic human and economic impacts and currently has infected over 10 million people and killed over 500,000

 

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

July 24, 2020 - This is a PDF fle of a peer-reviewed paper that has been accepted for publication. Although unedited, the content has been subjected to preliminary formatting. 

 

Targeting SARS‐CoV‐2 RBD interface: a supervised computational data‐driven approach to identify potential modulators

July 23, 2020 - Coronavirus Disease 2019 (COVID‐19) has spread out as a pandemic threat affecting over 2 million people

 

Safety, tolerability, and clinical outcomes of hydroxychloroquine for hospitalized patients with coronavirus 2019 disease

July 23, 2020 - Severe acute respiratory coronavirus 2 (SARS-CoV-2) has caused a devastating worldwide pandemic. Hydroxychloroquine (HCQ) has in vitro activity against SARS-CoV-2, but clinical data supporting HCQ for coronavirus disease 2019 (COVID-19) are limited

 

Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19

July 23, 2020 - Hydroxychloroquine and azithromycin have been used to treat patients with coronavirus disease 2019 (Covid-19). However, evidence on the safety and efficacy of these therapies is limited.

 

Tocilizumab for severe COVID-19: a systematic review and meta-analysis

July 23, 2020 - This systemic review and meta-analysis aimed to assess the efficacy of tocilizumab for the treatment of severe coronavirus disease-2019 (COVID-19)

 

Ribavirin Therapy For Severe COVID-19: A Retrospective Cohort Study

July 23, 2020 - We aimed to compare ribavirin therapy for patients with severe COVID-19 with a supportive therapy only

 

Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatment

July 22, 2020 - The world has witnessed unimaginable damages at the hands of the coronavirus disease-19 (COVID-19) pandemic

 

Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19

July 22, 2020 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense, single-stranded RNA virus that causes the potentially lethal Covid-19 respiratory tract infection

 

Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike

July 22, 2020 - The SARS-CoV-2 pandemic rages on with devasting consequences on human lives and the global economy

 

Rationale and evidence on the use of tocilizumab in COVID-19: a systematic review

July 20, 2020 - Tocilizumab is an IL-6 receptor-blocking agent proposed for the treatment of severe COVID-19

 

Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebocontrolled, phase 2 trial

July 20, 2020 - This is the first randomised controlled trial for assessment of the immunogenicity and safety of a candidate non-replicating adenovirus type-5 (Ad5)-vectored COVID-19 vaccine, aiming to determine an appropriate dose of the candidate vaccine for an efficacy study

 

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

July 20, 2020 - The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might be curtailed by vaccination

 

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

July 17, 2020 - Coronavirus disease 2019 (Covid-19) is associated with diffuse lung damage. Glucocorticoids may modulate inflammation-mediated lung injury and thereby reduce progression to respiratory failure and death

 

Effects on QT interval of hydroxychloroquine associated with ritonavir/darunavir or azithromycin in patients with SARS-CoV-2 infection

July 16, 2020 - To evaluate the effects of an association therapy of hydroxychloroquine (HY) plus ritonavir/darunavir (RD) or azithromycin (AZ) on QTc intervals

 

Exploring an Integrative Therapy for Treating COVID-19: A Randomized Controlled Trial

July 16, 2020 - To develop a new Chinese medicine (CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome (ARDS) in COVID-19 patients

 

Intermolecular interaction among Remdesivir, RNA and RNA-dependent RNA polymerase of SARS-CoV-2 analyzed by fragment molecular orbital calculation

July 15, 2020 - COVID-19, a disease caused by a new strain of coronavirus (SARS-CoV-2) originating from Wuhan, China, has now spread around the world, triggering a global pandemic, leaving the public eagerly awaiting the development of a specific medicine and vaccine

 

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

July 14, 2020 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and spread globally, prompting an international effort to accelerate development of a vaccine

 

Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines

July 14, 2020 - Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, it has spread rapidly worldwide and poses a great threat to public health

 

The renin–angiotensin–aldosterone system: Role in pathogenesis and potential therapeutic target in COVID‐19

July 13, 2020 - Coronavirus disease 2019 (COVID‐19), caused by the SARS‐CoV‐2 novel coronavirus, has spread worldwide causing high fatality rates

 

A perspective on potential antibodydependent enhancement of SARS-CoV-2

July 13, 2020 - This is a PDF fle of a peer-reviewed paper that has been accepted for publication

 

An overview of the safety, clinical application and antiviral research of the COVID-19 therapeutics

July 13, 2020 - Since a novel coronavirus pneumonia outbreak in late December 2019, coronavirus disease -19 (COVID-19) epidemic has gradually spread worldwide, becoming a major public health event

 

Renin-Angiotensin System Blockade in COVID-19: Good, Bad, or Indifferent?

July 13, 2020 - Based on the observation that patients with hypertension appear to have adverse outcomes with coronavirus disease-2019 

 

Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19

July 12, 2020 - In a longitudinal analysis of SARS-CoV-2- infected people, Kreer et al. find highly potent neutralizing antibodies that use a broad spectrum of variable (V) genes and show low levels of somatic mutations

 

A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection

July 12, 2020 - COVID-19, is a disease resulting from the SARS-CoV-2 global pandemic. Due to the current global emergency and the length of time required to develop specific antiviral agent(s) and a vaccine for SARS-CoV-2

 

Tocilizumab for treatment of mechanically ventilated patients with COVID-19

July 11, 2020 - Severe COVID-19 can manifest in rapid decompensation and respiratory failure with elevated inflammatory markers, consistent with cytokine release syndrome for which IL-6 blockade is approved treatment

 

Comparison of hydroxychloroquine, lopinavir/ritonavir, and standard of care in critically ill patients with SARS-CoV-2 pneumonia: an opportunistic retrospective analysis

July 11, 2020 - The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak is spreading worldwide.

 

Emerging pharmacological therapies for ARDS: COVID-19 and beyond

July 11, 2020 - Acute respiratory distress syndrome (ARDS) is the commonest form of acute severe hypoxemic respiratory failure in the critically ill

 

Control of SARS-CoV-2 infection in rituximab-treated neuroimmunological patients

July 11, 2020 - Individuals with autoimmune diseases, such as multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD), that require long-term immunosuppression are regarded as particularly vulnerable in the current COVID-19 pandemic

 

Bioinformatics analysis of epitope-based vaccine design against the novel SARS-CoV-2

July 10, 2020 - An outbreak of infection caused by SARS-CoV-2 recently has brought a great challenge to public health. Rapid identification of immune epitopes would be an efficient way to screen the candidates for vaccine development at the time of pandemic

 

Maior estudo sobre COVID-19 analisou proporção de anticorpos da população brasileira

10.07.2020 - O trabalho “Evolução da Prevalência de Infecção por Covid-19 no Brasil: Estudo de Base Populacional”, financiado pelo Ministério da Saúde e o maior já feito sobre a circulação do Sars-Cov-2 no país, foi concluído

 

Efficacy of Corticosteroids in Non-Intensive Care Unit Patients with COVID-19 Pneumonia from the New York Metropolitan region

July 10, 2020 - The role of systemic corticosteroid as a therapeutic agent for patients with COVID 19 pneumonia is controversial

 

COVID-19 and Mesenchymal Stem Cell Treatment; Mystery or Not

July 10, 2020 - On December 31, 2019, novel SARS-CoV2 spread from Wuhan China to more than 200 territories around world and the World Health Organization declared a COVID-19 pandemic on January 30, 2020

 

Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions

July 09, 2020 - - Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has resulted in a pandemic and continues to spread around the globe at an unprecedented rate

 

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

July 09, 2020 - The spread of the SARS-CoV-2 into a global pandemic within a few months of onset motivates the development of a rapidly scalable vaccine

 

Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management (Pilot Trial)

July 08, 2020 - To date no effective therapy has been demonstrated for COVID-19. In vitro, studies indicated that ivermectin (IVM) has antiviral effect

 

Renin-angiotensin-aldosterone system inhibitors and COVID-19 infection or hospitalization: a cohort study

July 07, 2020 - There are plausible mechanisms by which angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may increase the risk of COVID-19 infection or affect disease severity

 

SARS-CoV-2, ACE2, and Hydroxychloroquine: Cardiovascular Complications, Therapeutics, and Clinical Readouts in the Current Settings

July 07, 2020 - The rapidly evolving coronavirus disease 2019 (COVID-19, caused by severe acute respiratory syndrome coronavirus 2- SARS-CoV-2), has greatly burdened the global healthcare system and led it into crisis in several countries

 

GPU-Accelerated Drug Discovery with Docking on the Summit Supercomputer: Porting, Optimization, and Application to COVID-19 Research

July 06, 2020 - Protein-ligand docking is an in silico tool used to screen potential drug compounds for their ability to bind to a given protein receptor within a drug-discovery campaign 

 

Discovery of Drug-like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3

July 06, 2020 - The Mac1 domain of the multifunctional SARS-CoV-2 non-structural protein 3 (nsp3) is a potential COVID-19 drug target because it is suspected to enhance the ability of the virus to evade the human immune system

 

Conserved Genomic Terminals of SARS-CoV-2 as Co-evolving Functional Elements and Potential Therapeutic Targets

July 06, 2020 - To identify features in the genome of the SARS-CoV-2 pathogen responsible for the COVID-19 pandemic that may contribute to its viral replication, host pathogenicity, and vulnerabilities, we investigated how and to what extent the SARS-CoV-2 genome sequence differs from other well-characterized human and animal coronavirus genomes

 

Safety and efficacy of anti-il6-receptor tocilizumab use in severe and critical patients affected by coronavirus disease 2019: a comparative analysis

July 06, 2020 - This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record

Structural features of coronavirus SARS-CoV-2 spike protein: Targets for vaccination

July 06, 2020 - Various human pathogenic viruses employ envelope glycoproteins for host cell receptor recognition and binding, membrane fusion and viral entry

 

Role of IgD in prevention and treatment of SARS CoV-2 infection “The Unknown Soldier"

July 05, 2020 - COVID-19 presents varied clinical features, ranging from asymptomatic, mild, to acute respiratory distress syndrome (ARDS)

 

Potential effective treatment for COVID-19: systematic review and meta-analysis of the severe infectious disease with convalescent plasma therapy

July 04, 2020 - Convalescent plasma (CP) has been used successfully to treat many types of infectious diseases, and it has shown initial effects in the treatment of the emerging 2019 coronavirus disease (COVID-19)

Corticosteroid therapy for patients with CoVID-19 pneumonia: a before-after study

July 04, 2020 - Anti-inflammatory drugs such as corticosteroids may beneficially modulate the host inflammatory response to CoVID-19 pneumonia

 

Update on therapeutic approaches and emerging therapies for SARS-CoV-2 virus

July 04, 2020 - The global pandemic of coronavirus disease 2019 (COVID-19), caused by novel severe acute respiratory syndrome coronavirus

 

Recent insights for the emerging COVID-19: drug discovery, therapeutic options and vaccine development

July 04, 2020 - SARS-CoV-2 has been marked as a highly pathogenic coronavirus of COVID-19 disease into the human population, causing over 5.5 million confirmed cases worldwide

 

A Perspective on Emerging Therapeutic Interventions for COVID-19

July 03, 2020 - Coronaviruses are enveloped positive-sense RNA viruses with an unusual large RNA genome and a unique replication mechanism, which are characterized by club-like spikes that protrude from their surface

Efficacy and safety of umifenovir for coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

July 03, 2020 - We conducted this systemic review and meta‐analysis in an attempt to evaluate the efficacy and safety of umifenovir in COVID‐19 

 

Phylogenetic Analysis and Structural Perspectives of RNA-Dependent RNA-Polymerase Inhibition from SARs-CoV-2 with Natural Products

July 03, 2020 - Most recently, an outbreak of severe pneumonia caused by the infection of SARS-CoV-2, a novel coronavirus first identified in Wuhan, China, imposes serious threats to public health

 

Microstructure, pathophysiology and potential therapeutics of COVID‐19: A comprehensive review

July 03, 2020 - This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record

 

Turning the Tide: Natural Products and Natural-Product-Inspired Chemicals as Potential Counters to SARS-CoV-2 Infection

July 02, 2020 - The novel and highly pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has become a continued focus of global attention due to the serious threat it poses to public health

 

A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19

July 02, 2020 - The global Coronavirus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to unprecedented social and economic consequences

 

Whole Genome Analysis and Targeted Drug Discovery Using Computational Methods and High Throughput Screening Tools for Emerged Novel Coronavirus (2019-nCoV)

July 02, 2020 - A novel coronavirus designated as SARS-CoV-2 in February 2020 by World Health organization (WHO) was identified as main cause of SARS like pneumonia cases in Wuhan city in Hubei Province of China at the end of 2019

 

In silico Drug Repurposing to combat COVID-19 based on Pharmacogenomics of Patient Transcriptomic Data

June 30, 2020 - The ongoing global pandemic of coronavirus disease 2019 (COVID-19) continues to affect a growing number of populations in different parts of the world. In the current situation, drug repurposing is a viable strategy to combat COVID-19

 

O reposicionamento de fármacos como uma potencial estratégia para o tratamento da COVID-19

29 de junho de 2020 - No final de 2019 uma nova cepa de coronavírus foi descoberta na China, responsável por causar a doença COVID-19, caracterizada pela OMS como uma pandemia em março de 20207

 

Brasil entra em parceria para produção de vacina contra Covid-19

27 de Junho de 2020 - País receberá a transferência de tecnologia da tecnologia mais promissora contra a doença no mundo. Quando demonstrada segurança, serão 100 milhões de doses

 

Combating COVID-19 with integrated traditional Chinese and Western medicine in China

June 27, 2020 - COVID-19, an acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread throughout the world

 

The role of angiotensin-converting enzyme 2 in the pathogenesis of COVID-19: the villain or the hero?

June 27, 2020 - Angiotensin-converting enzyme 2 (ACE 2) is the entry receptor for the novel coronavirus SARS-CoV-2, the aetiological agent of COVID-19

 

Successful recovery from COVID-19 pneumonia after receiving baricitinib, tocilizumab, and remdesivir. A case report: Review of treatments and clinical role of computed tomography analysis

June 27, 2020 - The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic, threatening global public health

 

Drug treatment of coronavirus disease 2019 (COVID-19) in Chin

June 27, 2020 - Since December 2019, the coronavirus disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread throughout China as well as other countries

 

Convalescent Plasma Therapy in Coronavirus Disease 2019: a Case Report and Suggestions to Overcome Obstacles

June 26, 2020 - Coronavirus disease 2019 (COVID-19) is rapidly spreading around the world, causing much morbidity and mortality everywhere

 

Transcriptomic Signatures and Immunomodulatory Treatments for COVID-19 Patients

June 26, 2020 - Since December 2019, the novel coronavirus SARS-CoV-2 has infected over 9.0 million and led to death of over 472,000 people, damaging the world’s social and economic fabrics

 

SARS-CoV-2 Exoribonuclease (NSP14) As a Potential Therapeutic Target to Treat COVID-19

June 26, 2020 - Although the global health emergency caused by SARS-CoV-2 has led to unprecedented health and socioeconomic crisis, as of today neither an antiviral treatment has been approved for COVID-19, nor is a vaccine available

 

Glycans on the SARS-CoV-2 Spike Control the Receptor Binding Domain Conformation

June 26, 2020 - The glycan shield of the beta-coronavirus (β-CoV) Spike (S) glycoprotein provides protection from host immune responses, acting as a steric block to potentially neutralizing antibody responses

 

High-dose but not low-dose corticosteroids potentially delay viral shedding of patients with COVID-19

June 26, 2020 - Article PDF

 

Auxiliary role of mesenchymal stem cells as regenerative medicine soldiers to attenuate inflammatory processes of severe acute respiratory infections caused by COVID-19

June 25, 2020 - Acute respiratory infections as one of the most common problems of healthcare systems also can be considered as an important reason for worldwide morbidity and mortality from infectious diseases

 

Antiviral mechanisms of candidate chemical medicines and traditional Chinese medicines for SARS-CoV-2 infection

June 24, 2020 - The Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a global pandemic

 

Tocilizumab in patients with severe COVID-19: a retrospective cohort study

June 24, 2020 - No therapy is approved for COVID-19 pneumonia. The aim of this study was to assess the role of tocilizumab in reducing the risk of invasive mechanical ventilation and death in patients with severe COVID-19 pneumonia who received standard of care treatment

 

In-hospital Use of Statins is Associated with a Reduced Risk of Mortality among Individuals with COVID-19

June 24, 2020 - Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk of SARS-CoV-2 viral entry by inducing ACE2 expression

 

Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment

June 23, 2020 - While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis

 

Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies

June 23, 2020 - Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain (RBD) of the trimeric spike

 

Treatment of Coronavirus Disease 2019 (COVID-19): Investigational Drugs and Other Therapies

June 22, 2020 - Coronavirus disease 2019 (COVID-19) is defined as illness caused by a novel coronavirus now called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; formerly called 2019-nCoV), which was first identified amid an outbreak of respiratory illness cases in Wuhan City, Hubei Province, China

 

nCOV-19 peptides mass fingerprinting identification, binding, and blocking of inhibitors flavonoids and anthraquinone of Moringa oleifera and hydroxychloroquine

June 22, 2020 - An rare pandemic of viral pneumonia occurs in December 2019 in Wuhan, China, which is now recognized internationally as Corona Virus Disease 2019 (COVID-19), the etiological agent classified as Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2)

 

Constituents of buriti oil (Mauritia flexuosa L.) like inhibitors of the SARS-Coronavirus main peptidase: an investigation by docking and molecular dynamics

June 22, 2020 - Statistics show alarming numbers of infected and killed in the world, caused by the Covid-19 pandemic, which still doesn’t have a specific treatment and effective in combating all efforts to seek treatments and medications against this disease

Autophagy and SARS-CoV-2 infection: Apossible smart targeting of the autophagy pathway

June 22, 2020 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak resulted in 5,993,317 confirmed cases worldwide with 365,394 confirmed deaths (as  of  May  29 th ,  2020, WHO)

 

Structure-based virtual screening and molecular dynamics simulation of SARS-CoV-2 Guanine-N7 methyltransferase (nsp14) for identifying antiviral inhibitors against COVID-19

June 22, 2020 - The recent pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) calls the whole world into a medical emergency

 

Promising inhibitors of main protease of novel corona virus to prevent the spread of COVID-19 using docking and molecular dynamics simulation

June 22, 2020 - Coronavirus disease-2019 (COVID-19) is a global health emergency and the matter of serious concern, which has been declared a pandemic by WHO

 

Current status of COVID-19 therapies and drug repositioning applications

June 19, 2020 - The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for treatment of COVID-19

 

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

June 18, 2020 - During the COVID-19 pandemic, SARS-CoV-2 infected millions of people and claimed hundreds of thousands of lives

 

A narrative literature review on traditional medicine options for treatment of corona virus disease 2019 (COVID-19)

June 17, 2020 - Coronavirus disease 2019 (COVID-19) as a life-threatening disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is accounted as global public health concern

 

Overview of therapeutic drug research for COVID-19 in China

June 17, 2020 - Since the outbreak of novel coronavirus pneumonia (COVID-19) in December 2019, more than 2,500,000 people worldwide have been diagnosed with SARS-CoV-2 as of April 22. In response to this epidemic, China has issued seven trial versions of diagnosis and treatment protocol for COVID-19

 

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

June 15, 2020 - A new coronavirus SARS-CoV-2, also called novel coronavirus 2019 (2019-nCoV), started to circulate among humans around December 2019, and it is now widespread as a global pandemic

 

The use of renin angiotensin system inhibitor on mortality in patients with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis

June 14, 2020 - Coronavirus disease 2019, commonly known as COVID-19, is a raging global pandemic

 

Intracellular ABCB1 as a Possible Mechanism to Explain the Synergistic Effect of Hydroxychloroquine-Azithromycin Combination in COVID-19 Therapy

June 14, 2020 - The co-administration of hydroxychloroquine with azithromycin is proposed in COVID-19 therapy

 

Antiviral activity of the high-molecular-weight plant polysaccharides (Panavir(R))

June 14, 2020 - This short report is dedicated to the description of the wide antiviral and antibacterial activity of the immune-modulating agent Panavir(R)

 

Coronavirus breakthrough: dexamethasone is first drug shown to save lives

June 13, 2020 - In a large trial, a cheap and widely available steroid cut deaths by one-third among patients critically ill with COVID-19

 

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial

June 13, 2020 - A vaccine to protect against COVID-19 is urgently needed. We aimed to assess the safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 (Ad5) vectored COVID-19 vaccine expressing the spike glycoprotein of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain

 

Vaccination strategies to combat novel corona virus SARS-CoV-2

June 12, 2020 - The 2019-novel coronavirus disease (COVID-19) is caused by SARS-CoV-2 is transmitted from human to human has recently reported in China

 

Virtual screening, ADME/Tox predictions and the drug repurposing concept for future use of old drugs against the COVID-19

June 11, 2020 - The new Coronavirus (SARS-CoV-2) is the cause of a serious infection in the respiratory tract called COVID-19

 

Potential of coronavirus 3C-like protease inhibitors for the development of new anti-SARS-CoV-2 drugs: Insights from structures of protease and inhibitors

June 11, 2020 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to SARS-CoV and the Middle East respiratory syndrome coronavirus (MERS-CoV), which belong to the same β-coronavirus group, induces sever acute respiratory disease, threatening human health

 

Prospects of Replication-Deficient Adenovirus Based Vaccine Development against SARS-CoV-2

June 10, 2020 - The current appearance of the new SARS coronavirus 2 (SARS-CoV-2) and it quickly spreading across the world poses a global health emergency

 

Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)

June 10, 2020 - The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signals an urgent need for an expansion in treatment options

 

Aminoglycosides can be a better choice over macrolides in COVID-19 regimen: Plausible mechanism for repurposing strategy

June 10, 2020 - In the current COVID-19 pandemic, prioritizing the immunity enhancers is equally important to anti-virals

 

BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)

June 09, 2020 - The bacillus Calmette−Guérin (BCG) vaccine, an attenuated Mycobacterium bovis (1), has been extensively used in national vaccination programs, as it confers cross-protection from Mycobacterium tuberculosis infection 

 

Statins as early therapy to mitigate COVID-19 (SARS-CoV-2)-associated ARDS and cytokine storm syndrome – time is of the essence

June 09, 2020 -While most coronavirus disease 2019 (COVID-19) infections run a benign course with recovery, the inexorable rise in case fatalities in several countries is grim testimony to the lack of effective therapies to arrest the course of severe infections

 

Vacina nacional de Bio-Manguinhos/Fiocruz para novo coronavírus entrará em estudo pré-clínico

09.06.2020 - Vacina nacional de Bio-Manguinhos/Fiocruz para novo coronavírus entrará em estudo pré-clínico. Projeto está pronto para avançar em estudos in vivo

 

Narrative review of the immune response against coronavirus: An overview, applicability for SARS-COV-2, and therapeutic implications

June 8, 2020 - The new coronavirus (SARS-CoV-2) that causes a severe acute respiratory syndrome emerges in Wuhan, China, in December 2019

 

EMA receives application for conditional authorisation of first COVID-19 treatment in the EU

June 08, 2020 - EMA has now received an application for conditional marketing authorisation (CMA) of the antiviral medicine remdesivir for the treatment of COVID-19 and has formally started its evaluation

 

α-glucosidase inhibitors as host-directed antiviral agents with potential for the treatment of COVID-19

June 08, 2020 - The ongoing COVID-19 pandemic, caused by SARS-CoV-2, has pushed the health systems of many countries to breaking point and precipitated social distancing measures that have crippled economic activities across the globe

 

Monoclonal antibody as a potential anti-COVID-19

June 04, 2020 - Coronavirus disease 2019 (COVID-19) is expanding rapidly, which made it as one of top priorities for scientists to develop novel treatment strategies

 

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

June 3, 2020 - Coronavirus disease 2019 (Covid-19) occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For persons who are exposed, the standard of care is observation and quarantine

 

Natural RNA dependent RNA polymerase inhibitors: Molecular docking studies of some biologically active alkaloids of Argemone mexicana

June 01, 2020 - COVID-19 has become disastrous for world and spread all over. Researchers all around the globe are working to discover a drug to cure from COVID-19

 

Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients

June 01, 2020 - Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards the development of sensitive diagnostic

 

Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

May 29, 2020 - To date, no vaccines or effective drugs have been approved to prevent or treat COVID-19 and the current standard care relies on supportive treatments

 

Potentially repurposable drugs for COVID-19 identified from SARS-CoV-2 Host Protein Interactome

May 28, 2020 - We previously presented the protein-protein interaction network (‘HoP Interactome’) of 332 host proteins that were identified to interact with 27 nCoV19 viral proteins by Gordon et al

 

Lopinavir-ritonavir versus hydroxychloroquine for viral clearance and clinical improvement in patients with mild to moderate coronavirus disease 2019

May 27, 2020 - The efficacies of lopinavir-ritonavir or hydroxychloroquine remain to be determined in patients with coronavirus disease 2019 (COVID-19

 

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19

May 27, 2020 - Remdesivir is an RNA polymerase inhibitor with potent antiviral activity in vitro and efficacy in animal models of coronavirus disease 2019 (Covid-19)

 

Evaluation of the efficacy and safety of intravenous remdesivir in adult patients with severe COVID-19: study protocol for a phase 3 randomized, double-blind, placebo-controlled, multicentre trial

May 24, 2020 - Coronavirus disease 2019 (COVID-19), caused by a novel corinavirus (later named SARS-CoV-2 virus), was fistly reported in Wuhan, Hubei Province, China towards the end of 2019. 

 

A human neutralizing antibody targets the receptor binding site of SARS-CoV-2

May 22, 2020 - An outbreak of the coronavirus disease 2019 (COVID-19)1–3, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)4 spread globally

 

Remdesivir for the Treatment of Covid-19 — Preliminary Report

May 22, 2020 - Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), none have yet been shown to be efficacious

 

Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

May 22, 2020 - Often in combination with a second-generation macrolide, are being widely used for treatment of COVID-19, despite no conclusive evidence of their benefit

 

No Benefit for Lopinavir–Ritonavir in Severe COVID-19

May 21, 2020 - Treatment with the HIV combination drug lopinavir-ritonavir did not accelerate recovery or improve mortality rates among hospitalized patients with severe coronavirus disease 2019 (COVID-19), a trial in the New England Journal of Medicine reported.

 

Beximco Pharma introduces world’s first generic remdesivir for COVID-19 treatment

May 21, 2020 -Beximco Pharmaceuticals Limited (“Beximco Pharma”, “BPL” or “the Company”), the fast-growing manufacturer of generic pharmaceutical products and active pharmaceutical ingredients, announces the launch of remdesivir (under the brand name Bemsivir), an antiviral drug, which has been recently granted Emergency Use Authorization by the U.S. Food and Drug Administration for the treatment of COVID-19

 

An in-silico approach to develop of a multi-epitope vaccine candidate against SARS-CoV-2 envelope (E) protein

May 20, 2020 - Since the rst appearance of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS- CoV-2) in China on December 2019, the world has now witnessed the emergence of the SARS- CoV-2 outbreak 

 

Immunogenicity of a DNA vaccine candidate for COVID-19

May 20, 2020 - The coronavirus family member, SARS-CoV-2 has been identified as the causal agent for the pandemic viral pneumonia disease, COVID-19

 

Ministério da Saúde divulga diretrizes para tratamento medicamentoso de pacientes

20.05.2020 - As recomendações publicadas nesta quarta-feira (20) são para o tratamento precoce, com cloroquina e hidroxicloroquina, de pacientes com COVID-19, no Sistema Único da Saúde (SUS) 

 

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

May 18, 2020 - SARS-CoV-2 is a newly emerged coronavirus responsible for the current COVID-19 pandemic that has resulted in more than 3.7 million infections and 260,000 deaths as of 6 May 2020 

 

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

May 14, 2020 - A novel coronavirus was recently discovered and termed SARS-CoV-2. Human infection can cause coronavirus disease 2019 (COVID-19), which has been rapidly spreading around the globe1,2

 

JAK Inhibition as a New Treatment Strategy for Patients with COVID-19

May 11, 2020 - After the advent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the outbreak of coronavirus disease 2019 (COVID-19) commenced across the world

 

An Update on Current Therapeutic Drugs Treating COVID-19

May 11, 2020 - The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presented unprecedented challenges to the healthcare systems in almost every country around the world

 

Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State

May 11, 2020 - Among patients with coronavirus disease 2019 (COVID-19), is there an association between use of hydroxychloroquine, with or without azithromycin, and in-hospital mortality?

 

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

May 08, 2020 - Effective antiviral therapy is important for tackling the coronavirus disease 2019 (COVID-19) pandemic. We assessed the efficacy and safety of combined interferon beta-1b, lopinavir–ritonavir, and ribavirin for treating patients with COVID-19

 

The COVID-19 Gene and Drug Set Library

May 06, 2020 - The coronavirus (CoV) severe acute respiratory syndrome (SARS)-CoV-2 (COVID-19) pandemic has received rapid response by the research community to offer suggestions for repurposing of approved drugs as well as to improve our understanding of the COVID-19 viral life cycle molecular

 

Coronavirus (COVID-19) Update: FDA Issues Emergency Use Authorization for Potential COVID-19 Treatment

May 01, 2020 - Today, the U.S. Food and Drug Administration issued an emergency use authorization for the investigational antiviral drug remdesivir for the treatment of suspected or laboratory-confirmed COVID-19 in adults and children hospitalized with severe disease

Identification of new drug treatments to combat COVID19: A signature-based approach using iLINCS

April 30, 2020 - The COVID-19 pandemic caused by the novel SARS-CoV-2 is more contagious than other coronaviruses and has higher rates of mortality than influenza

 

EMA starts rolling review of remdesivir for COVID-19

April 30, 2020 - EMA’s human medicines committee (CHMP) has started a ‘rolling review’ of data on the use of the investigational antiviral medicine remdesivir for the treatment of coronavirus disease (COVID-19)

 

Plataforma reúne gráficos interativos sobre a evolução da COVID-19 no Brasil

30.04.2020 - Os gráficos mostram a quantidade total de casos e óbitos confirmados, a incidência na população, a taxa de letalidade e o número de novos casos

 

Hopes rise for coronavirus drug remdesivir

April 29, 2020 - Despite conflicting studies, results from largest trial yet show the antiviral speeds up recovery, putting it on track to become a standard of care in the United States

 

Covid-19 Drugs & Vaccines Tracker

April, 2020 - In the months since the novel coronavirus rose from a regional crisis to a global threat, drug makers large and small have scrambled to advance their best ideas for thwarting a pandemic

 

COVID-19 Resource Centre

April 25, 2020 - To assist health workers and researchers working under challenging conditions to bring this outbreak to a close, The Lancet has created a Coronavirus Resource Centre. This resource brings together new 2019 novel coronavirus disease (COVID-19) content from across The Lancet journals as it is published. All of our COVID-19 content is free to access

 

Covid-19 Arrived in Seattle. Where It Went From There Stunned the Scientists

April 22, 2020 - As the coronavirus outbreak consumed the city of Wuhan in China, new cases of the virus began to spread out like sparks flung from a fire

 

Información técnica, precios y registros sanitarios de pruebas diagnósticas para detección del virus SARS-CoV-2 en 5 países de América Latina y otras regiones

Abil de 2020 - Información técnica, precios y registros sanitarios de pruebas diagnósticas para detección del virus SARS-CoV-2 en 5 países de América Latina y otras regiones

 

Exceptional GMP flexibilities for medicines manufacturers during the coronavirus (COVID-19) outbreak

April 22, 2020 - These temporary good manufacturing practice (GMP) flexibilities will be allowed to address the current exceptional circumstances

 

Connecting clusters of COVID-19: an epidemiological and serological investigation

April 21, 2020 - Elucidation of the chain of disease transmission and identification of the source of coronavirus disease 2019 (COVID-19) infections are crucial for effective disease containment

 

Coronavirus Infections May Not Be Uncommon, Tests Suggest

April 21, 2020 - Two preliminary efforts to survey citizens for antibodies to the virus have produced controversial results

 

Developing therapeutic monoclonal antibodies at pandemic pace

April 21, 2020 -The time from discovery to proof-of-concept trials could be reduced to 5–6 months from a traditional timeline of 10–12 months

 

Coronavirus (COVID-19) Update: FDA Authorizes First Test for Patient At-Home Sample Collection

April 21, 2020 - The U.S. Food and Drug Administration authorized the first diagnostic test with a home collection option for COVID-19

 

Launch of enhanced monitoring system for availability of medicines used for treating COVID-19

April 21, 2020 - EMA, together with the pharmaceutical industry and the EU Member States, has launched its enhanced fast-track monitoring system to help prevent and mitigate supply issues with crucial medicines used for treating patients with COVID-19

 

Update to guidance on regulatory expectations in the context of COVID-19 pandemic 

April 20, 2020 - The European Commission, EMA and the national competent authorities have agreed a series of measures to mitigate the impact of disruptions caused by COVID-19 on the conduct0 of inspections of manufacturing facilities or other sites relevant for medicinal products in the European Union

 

Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) - an update on the status

April 19, 2020 - Coronaviruses are a large group of viruses known to cause illnesses that vary between the common cold and more severe diseases to include severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS)

 

NIH to launch public-private partnership to speed COVID-19 vaccine and treatment options

April 17, 2020 - The National Institutes of Health and the Foundation for the NIH (FNIH) are bringing together more than a dozen leading biopharmaceutical companies, the Health and Human Services Office of the Assistant Secretary for Preparedness and Response, the Centers for Disease Control and Prevention, the U.S.

 

Immunity from COVID-19 antibodies not certain, HIV co-discoverer cautions

April 14, 2020 - The race is on to develop and distribute antibody tests for the coronavirus, driven by the idea that these tests will inform individuals when they are immune to the virus and can return to their normal lives

 

Drug Evaluation during the Covid-19 Pandemic

April 14, 2020 - The search for a treatment for Covid-19 is testing our country’s ability to quickly develop, test, and deploy medications, presenting both opportunities and challenges to our drug-assessment apparatus

 

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)

April 13, 2020 - The pandemic of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an unprecedented challenge to identify effective drugs for prevention and treatment

 

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)

April 13, 2020 - The pandemic of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an unprecedented challenge to identify effective drugs for prevention and treatment

 

Trade set to plunge as COVID-19 pandemic upends global economy

April 13, 2020 - World trade is expected to fall by between 13% and 32% in 2020 as the COVID 19 pandemic disrupts normal economic activity and life around the world

 

Update on EU actions to support availability of medicines during COVID-19 pandemic

April 10, 2020 - The continued availability of medicines is one of the most important priorities for EU authorities that are adopting measures to mitigate possible disruptions to the supply of medicines caused by the ongoing COVID-19 pandemic

 

Compassionate Use of Remdesivir for Patients with Severe Covid-19

April 10, 2020 -O remdesivir, um pró-fármaco análogo de nucleotídeo que inibe a polimerase de RNA viral, demonstrou atividade in vitro contra SARS-CoV-2

 

COVID-19 and risks to the supply and quality of tests, drugs, and vaccines

April 09, 2020 - Emergency efforts are underway to find optimum medical products to prevent infection and diagnose and treat patients during the coronavirus disease 2019 (COVID-19) pandemic

 

Structure of Mpro from COVID-19 virus and discovery of its inhibitors

April 09, 2020 - A new coronavirus (CoV) identified as COVID-19 virus is the etiological agent responsible for the 2019-2020 viral pneumonia outbreak that commenced in Wuhan

 

Treatment options for COVID-19: The reality and challenges

April 04, 2020 - An outbreak related to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China in December 2019

 

Situação patentária de produtos passíveis para uso contra à Covid-19

09.04.2020 - Dando prosseguimento ao estudo sobre possíveis moléculas e produtos para tratamento e prevenção da COVID-19, após os estudos elaborados a partir das informações obtidas no estudo publicado pela American Chemical Society , a ABIFINA traz um levantamento das patentes correspondentes brasileiras de produtos já comercializados para prevenção e tratamento de outras doenças que possam ser utilizados para prevenção e tratamento de COVID-19

 

Global regulators stress need for robust evidence on COVID-19 treatments

April 09, 2020 - International regulators have published a report today highlighting their considerations on the development of potential COVID-19 therapeutics, clinical trials and compassionate use programmes

 

BMJ's Coronavirus (covid-19) Hub

April 09, 2020 -BMJ's covid-19 hub supports health professionals and researchers with practical guidance, online CPD courses, as well as the latest news, comment, and research from The BMJ.

 

Situação patentária de vacinas relacionadas à Covid-19

08.04.2020 - Dando prosseguimento ao estudo sobre possíveis moléculas para tratamento e prevenção da COVID-19, a partir das informações obtidas no estudo publicado pela American Chemical Society , a ABIFINA traz um levantamento das patentes correspondentes brasileiras de vacinas que possam ser utilizadas na pandemia de COVID-19

 

Global regulators discuss observational studies of real world data for COVID-19 medicines 

April 07, 2020 - In a dedicated COVID-19 workshop, organised by the European Medicines Agency (EMA) under the umbrella of the International Coalition of Medicines Regulatory Authorities (ICMRA), international regulators discussed how data generated during clinical practice could complement evidence from clinical trials with potential therapeutics or vaccines against COVID-19

 

Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production

April 07, 2020 - Besides social isolation, identification of the suitable clinically approved drugs to be repurposed could lead to short-term action to reduce mortality

 

Open for outbreaks

April 07, 2020 - In the onslaught of the COVID-19 pandemic, the open sharing of materials, information and data is gaining increasing importance in biotech.

 

Coalition launched to accelerate research on the prevention and treatment of COVID-19 in low- and middle-income countries

April 03, 2020 - A group of scientists, physicians, funders, and policy makers from over 70 institutions from over 30 countries have launched an international coalition to respond to COVID-19 in resource-poor settings

 

EMA provides recommendations on compassionate use of remdesivir for COVID-19

April 03, 2020 - During an extraordinary virtual meeting held on 2 April 2020, EMA’s human medicines committee (CHMP) gave recommendations on how the investigational antiviral medicine remdesivir should be used for treating coronavirus disease (COVID-19) in compassionate use programmes in the European Union

 

International regulators discuss available knowledge supporting COVID-19 medicine development

April 03, 2020 - On 2 April, regulators from around the world joined the second workshop on COVID-19 organised by the European Medicines Agency (EMA) under the umbrella of the International Coalition of Medicines Regulatory Authorities (ICMRA)

 

Systematic review of the efficacy and safety of antiretroviral drugs against SARS, MERS, or COVID‐19: initial assessment

April 02, 2020 - Several antiretroviral drugs are being considered the treatment of COVID‐19, the disease caused by a newly identified coronavirus, (SARS‐CoV‐2).

 

HHS accepts donations of medicine to Strategic National Stockpile as possible treatments for COVID-19 patients

April 02, 2020 - FDA issues emergency use authorization for donated hydroxychloroquine sulfate, chloroquine phosphate

 

Coronavirus disease (COVID-2019) R&D

April 02, 2020 - On 31 December 2019, WHO was informed of a cluster of cases of pneumonia of unknown cause detected in Wuhan City, Hubei Province of China

 

Optimizing the Trade-off Between Learning and Doing in a Pandemic

April 02, 2020 - The world is united regarding the goal of ending the coronavirus disease 2019 (COVID-19) pandemic but not the strategy to achieve that goal

 

COVID-19: combining antiviral and anti-inflammatory treatments

April 01, 2020 - Both coronavirus disease 2019 (COVID-19) and severe acute respiratory syndrome (SARS) are characterised by an overexuberant inflammatory response and, for SARS, viral load is not correlated with the worsening of symptoms

 

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

March 30, 2020 - The renin–angiotensin– aldosterone system (RAAS) is an elegant cascade of vasoactive peptides that orchestrate key processes in human physiology.

 

NOTA INFORMATIVA Nº 5/2020-DAF/SCTIE/MS

27.03.2020 - Uso da Cloroquina como terapia adjuvante no tratamento de formas graves do COVID-19

 

Use of antiviral drugs to reduce COVID-19 transmission 

March 27, 2020 - As the coronavirus disease 2019 (COVID-19) spreads, efforts are being made to reduce transmission via standard public health interventions based on isolation of cases and tracing of contacts.

 

EMA advises continued use of medicines for hypertension, heart or kidney disease during COVID-19 pandemic

March 27, 2020 - EMA is aware of recent media reports and publications which question whether some medicines, for instance angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs, or sartan medicines), could worsen coronavirus disease (COVID-19)

 

Exportação de cloroquina e azitromicina: veja a RDC 352

March 27, 2020 - De acordo com a Resolução da Diretoria Colegiada 352, a exportação necessitará temporariamente de autorização prévia da Anvisa.

 

Situação patentária de moléculas e composições relacionadas à Covid-19

25.03.2020 - Diante da pandemia da COVID-19, e a partir das informações obtidas por um estudo publicado pela American Chemical Society , a ABIFINA fez um levantamento preliminar das patentes brasileiras correspondentes para as moléculas que estão sendo estudadas para prevenção e/ou tratamento da COVID-19. 

 

Gilead Declines 'Rare Disease' Status For Experimental Coronavirus Drug

March 26, 2020 - In a surprising turnabout, drugmaker Gilead Sciences asked the Food and Drug administration on Wednesday to rescind orphan status for remdesivir, the company's experimental coronavirus treatment

 

India bans exports of drug touted by Trump as potential Covid-19 treatment

March 26, 2020 - Amendment in Export Policy of Hydroxychloroquine

 

Global regulatory workshop on COVID-19 vaccine development

March 25, 2020 - A virtual meeting, held under the umbrella of the International Coalition of Medicines Regulatory Authorities (ICMRA), convening experts from medicines regulatory authorities, the World Health Organisation (WHO) and the European Commission 

 

Comparison of Lopinavir/Ritonavir or Hydroxychloroquine in Patients With Mild Coronavirus Disease (COVID-19)

March 25, 2020 - In vitro studies revealed that lopinavir/ritonavir and hydroxychloroquine have antiviral activity against Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

 

The Official Chinese Government Guide to Diagnosing and Treating the Novel Coronavirus

March 25, 2020 - You may not have heard of it. It’s now on version 7. You should read it.

 

Resources and Use of Approved Therapies for Treatment of n-CoViD-19 Disease

March 2020 - Therapies Approved by US FDA for Other Conditions

 

Insights from nanomedicine into chloroquine efficacy against COVID-19

March 23, 2020 - Chloroquine — an approved malaria drug — is known in nanomedicine research for the investigation of nanoparticle uptake in cells, and may have potential for the treatment of COVID-19

 

FDA and EMA Collaborate to Facilitate SARS-CoV-2 Vaccine Development

March 23, 2020 - Vaccines offer a way to build immunity to a disease-causing microorganism before one has ever been exposed to it. They have been highly effective in preventing a whole range of serious infectious diseases

 

The first study of a potential coronavirus vaccine will soon start recruiting healthy volunteers in Georgia at Emory University

Mar 23, 2020 - A pharmacist gives Jennifer Haller, left, the first shot in the first-stage safety study clinical trial of a potential vaccine for COVID-19, the disease caused by the new coronavirus, Monday, March 16, 2020, at the Kaiser Permanente Washington Health Research Institute in Seattle. 

 

Genentech Announces FDA Approval of Clinical Trial for Actemra to Treat Hospitalized Patients With Severe COVID-19 Pneumonia

March 23, 2020 - Genentech will also provide 10,000 vials of Actemra to the U.S. Strategic National Stockpile. Current U.S. supply of Actemra for approved indications is not expected to be impacted 

 

WHO launches global megatrial of the four most promising coronavirus treatments

Mar. 22, 2020 - Could any of these drugs hold the key to saving coronavirus disease 2019 (COVID-19) patients from serious harm or death? On Friday, the World Health Organization (WHO) announced a large global trial, called SOLIDARITY, to find out whether any can treat infections with the new coronavirus for the dangerous respiratory disease. 

 

The pandemic pipeline

20 March 2020 - Companies are doing their best to accelerate experimental drugs and vaccines for COVID-19 through the pipeline. Each faces its own set of challenges, but all agree on the need for a radical rethink of the clinical development process for pandemics. 

 

The pandemic pipeline

20 March 2020 - Companies are doing their best to accelerate experimental drugs and vaccines for COVID-19 through the pipeline. Each faces its own set of challenges, but all agree on the need for a radical rethink of the clinical development process for pandemics. 

 

Chloroquine, Past and Present

20 March, 2020 - Derek Lowe's commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine. All content is Derek’s own, and he does not in any way speak for his employer.

 

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

March 18, 2020 - No therapeutics have yet been proven effective for the treatment of severe illness caused by SARS-CoV-2

 

Sanofi, Regeneron test arthritis drug against COVID-19

March 18, 2020 - New study explores whether dampening IL-6 could address serious coronavirus infections 

 

Chilean Chamber of Deputies approves resolution for compulsory licenses for patents relating to the coronavirus virus

March 17, 2020 - Today, with an overwhelming 127 votes in favor and 0 votes against, the Chilean Chamber of Deputies approved a strong resolution asking the Chilean Government to declare that there is justification for compulsory licenses for vaccines, drugs, diagnostics, devices, supplies, and other technologies useful for the surveillance, prevention, detection, diagnosis and treatment of people infected by the coronavirus virus in Chile.

 

Hydroxychloroquine would be effective, according to Professor Raoult of the IHU in Marseille, after a first limited test

March 17, 2020 - Professor Didier Raoult, director of the IHU in Marseille, presented the first results of the hydroxychloroquine clinical test carried out on 24 patients suffering from coronavirus.

 

Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus

16 March 2020 - Estimation of the prevalence and contagiousness of undocumented novel coronavirus (SARS-CoV2) infections is critical for understanding the overall prevalence and pandemic potential of this disease.

 

Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases

March 12, 2020 - Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, this disease has spread rapidly around the globe. Considering the potential threat of a pandemic, scientists and physicians have been racing to understand this new virus and the pathophysiology of this disease to uncover possible treatment regimens and discover effective therapeutic agents and vaccine

 

 

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